Search Results - "Kawamura, Yumiko"
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Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos
Published in Molecular cell (20-02-2020)“…In mammals, chromatin organization undergoes drastic reorganization during oocyte development. However, the dynamics of three-dimensional chromatin structure…”
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Maternal enzyme reprograms paternal DNA for healthy offspring
Published in Nature (London) (01-05-2022)“…It emerges that high blood sugar deregulates the enzyme TET3 in the eggs of female mice, preventing it from properly modifying sperm-derived DNA when eggs are…”
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Antagonism between H3K27me3 and genome–lamina association drives atypical spatial genome organization in the totipotent embryo
Published in Nature genetics (16-09-2024)“…In mammals, early embryonic development exhibits highly unusual spatial positioning of genomic regions at the nuclear lamina, but the mechanisms underpinning…”
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4
Cooperation between HDAC3 and DAX1 mediates lineage restriction of embryonic stem cells
Published in The EMBO journal (15-06-2021)“…Mouse embryonic stem cells (mESCs) are biased toward producing embryonic rather than extraembryonic endoderm fates. Here, we identify the mechanism of this…”
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5
Epigenetic regulation limits competence of pluripotent stem cell‐derived oocytes
Published in The EMBO journal (01-12-2023)“…Recent studies have reported the differentiation of pluripotent cells into oocytes in vitro. However, the developmental competence of in vitro‐generated…”
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Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest
Published in The Journal of clinical investigation (01-08-2010)“…Sirtuins are a phylogenetically conserved NAD+-dependent protein deacetylase/ADP-ribosyltransferase family implicated in diverse biological processes. Several…”
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Maintenance of genomic methylation patterns during preimplantation development requires the somatic form of DNA methyltransferase 1
Published in Developmental biology (2008)“…DNA methylation at cytosine residues in CpG dinucleotides is a component of epigenetic marks crucial to mammalian development. In preimplantation stage…”
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8
Calpain-6 deficiency promotes skeletal muscle development and regeneration
Published in PLoS genetics (01-08-2013)“…Calpains are Ca(2+)-dependent modulator Cys proteases that have a variety of functions in almost all eukaryotes. There are more than 10 well-conserved…”
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Dnm3os, a non‐coding RNA, is required for normal growth and skeletal development in mice
Published in Developmental dynamics (01-12-2008)“…Dnm3os, a gene that is transcribed into a non‐coding RNA (ncRNA), contains three micro RNAs (miRNAs), miR‐199a, miR‐199a*, and miR‐214, whose functions remain…”
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SIRT3 Positively Regulates the Expression of Folliculogenesis- and Luteinization-Related Genes and Progesterone Secretion by Manipulating Oxidative Stress in Human Luteinized Granulosa Cells
Published in Endocrinology (Philadelphia) (01-08-2014)“…SIRT3 is a member of the sirtuin family and has recently emerged as a vital molecule in controlling the generation of reactive oxygen species (ROS) in oocytes…”
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11
Probing the origin of matching functional jaws: roles of Dlx5/6 in cranial neural crest cells
Published in Scientific reports (08-10-2018)“…Gnathostome jaws derive from the first pharyngeal arch (PA1), a complex structure constituted by Neural Crest Cells (NCCs), mesodermal, ectodermal and…”
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Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation
Published in Nature metabolism (01-02-2021)“…Ketone bodies are generated in the liver and allow for the maintenance of systemic caloric and energy homeostasis during fasting and caloric restriction. It…”
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13
An Endothelin-1 Switch Specifies Maxillomandibular Identity
Published in Proceedings of the National Academy of Sciences - PNAS (02-12-2008)“…Articulated jaws are highly conserved structures characteristic of gnathostome evolution. Epithelial-mesenchymal interactions within the first pharyngeal arch…”
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14
Primed Track, high-fidelity lineage tracing in mouse pre-implantation embryos using primed conversion of photoconvertible proteins
Published in eLife (21-01-2019)“…Accurate lineage reconstruction of mammalian pre-implantation development is essential for inferring the earliest cell fate decisions. Lineage tracing using…”
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Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster
Published in Communications biology (30-11-2020)“…Temporal and spatial colinear expression of the Hox genes determines the specification of positional identities during vertebrate development…”
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16
Endothelin receptor type A expression defines a distinct cardiac subdomain within the heart field and is later implicated in chamber myocardium formation
Published in Development (Cambridge) (15-11-2010)“…The avian and mammalian heart originates from two distinct embryonic regions: an early differentiating first heart field and a dorsomedially located second…”
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Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation
Published in Nature metabolism (18-02-2021)Get full text
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18
High blood sugar inherited through eggs
Published in Nature (London) (26-05-2022)“…Writing in Nature, Chen et al.3 reveal a mechanism through which high blood sugar - a sign of some metabolic disorders - is transmitted from female mice to…”
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Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development
Published in Development (Cambridge) (15-02-2008)“…The endothelin (Edn) system comprises three ligands (Edn1, Edn2 and Edn3) and their G-protein-coupled type A (Ednra) and type B (Ednrb) receptors. During…”
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Enhancing Membrane Permeability of Fluorescein-Type Chromophore Through Covalent Attachment of Chlorinated Dodecaborate
Published in Molecules (Basel, Switzerland) (17-11-2024)“…Anionic boron clusters, such as [B12X12]2− (X = Cl, Br, I), have attracted attention in pharmaceuticals due to their unique superchaotropic properties. In…”
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