Analysis of respiratory movements in a mouse model of late Parkinson’s disease submitted to stress

Analysis of respiratory movements in a mouse model of late Parkinson’s disease submitted to stress

•Respiratory movements suggested an obstructive type of respiratory dysfunction.•Changes included reduced diaphragmatic movement with compensatory thoracic breathing.•Acute-stress induced a decrease in the respiratory frequency. Parkinson’s disease (PD) is known to cause tremor and rigidity, but oth...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology Vol. 251; pp. 50 - 56
Main Authors: de Campos, P.S., Kawamura, L.R.S.M., Hasegawa, K., Kumei, Y., Zeredo, J.L.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01-05-2018
Subjects:
Animal
Behavior
Diaphragm
Disease models
Radiography
Respiration
Radiography
PD
Disease models
CPA
Animal
6-OHDA
Diaphragm
Behavior
Respiration
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Summary:•Respiratory movements suggested an obstructive type of respiratory dysfunction.•Changes included reduced diaphragmatic movement with compensatory thoracic breathing.•Acute-stress induced a decrease in the respiratory frequency. Parkinson’s disease (PD) is known to cause tremor and rigidity, but other symptoms such as respiratory and autonomic dysfunctions are a major cause of disability and mortality in patients. In this study, we examined respiratory movements by using cineradiography on a murine model of late/advanced PD. Under surgical anesthesia, C57BL/6J mice received an injection of either 6-OHDA or vehicle solution to the right striatum. Two weeks after surgery, the animals had their respiratory movements recorded by video X-ray without any restraint. During recordings the animals were submitted to a mild acute-stress challenge. Behavioral tests were performed to assess the severity of the 6-OHDA lesion. As a result, behavioral tests confirmed severe motor impairments in 6-OHDA mice as compared to controls. 6-OHDA mice showed a predominantly thoracic respiratory pattern with reduced diaphragmatic excursion, and reduced respiratory frequency after stress. These results suggest that advanced nigrostrial degeneration may cause respiratory alterations with the features of obstructive-type respiratory disorders.
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ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2018.02.012