Search Results - "Kawamoto, Manabu"

Role of osteoclasts and interleukin-17 in the pathogenesis of rheumatoid arthritis: crucial ‘human osteoclastology’ by Kotake, Shigeru, Yago, Toru, Kawamoto, Manabu, Nanke, Yuki

“…Many papers have reported that osteoclasts play an important role in the pathogenesis of rheumatoid arthritis (RA); however, when we started to investigate the…”
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IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats by Yago, Toru, Nanke, Yuki, Kawamoto, Manabu, Furuya, Takefumi, Kobashigawa, Tsuyoshi, Kamatani, Naoyuki, Kotake, Shigeru

“…This study demonstrates that IL-23 stimulates the differentiation of human osteoclasts from peripheral blood mononuclear cells (PBMC). Furthermore, in vivo…”
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The evaluation of gene polymorphisms associated with autoinflammatory syndrome in patients with palindromic rheumatism complicated by intermittent hydrarthrosis by Tani, Yumi, Kishi, Takayuki, Miyamae, Takako, Kawamoto, Manabu, Kawaguchi, Yasushi, Taniguchi, Atsuo, Yamanaka, Hisashi

“…Objectives Palindromic rheumatism (PR) is a type of acute arthritis or periarthritis characterized by recurrence, paroxysmal, or intermittent disease attacks…”
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IL-23 and Th17 Disease in Inflammatory Arthritis by Yago, Toru, Nanke, Yuki, Kawamoto, Manabu, Kobashigawa, Tsuyoshi, Yamanaka, Hisashi, Kotake, Shigeru

“…IL-23, which is composed of p19 and p40 subunits, is a proinflammatory cytokine that contributes to the formation and maintenance of Th17 cells in inflammatory…”
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Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population by Hotta, Kikuko, Nakamura, Michihiro, Nakamura, Takahiro, Matsuo, Tomoaki, Nakata, Yoshio, Kamohara, Seika, Miyatake, Nobuyuki, Kotani, Kazuaki, Komatsu, Ryoya, Itoh, Naoto, Mineo, Ikuo, Wada, Jun, Masuzaki, Hiroaki, Yoneda, Masato, Nakajima, Atsushi, Funahashi, Tohru, Miyazaki, Shigeru, Tokunaga, Katsuto, Kawamoto, Manabu, Ueno, Takato, Hamaguchi, Kazuyuki, Tanaka, Kiyoji, Yamada, Kentaro, Hanafusa, Toshiaki, Oikawa, Shinichi, Yoshimatsu, Hironobu, Nakao, Kazuwa, Sakata, Toshiie, Matsuzawa, Yuji, Kamatani, Naoyuki, Nakamura, Yusuke

“…There is evidence that the obesity phenotype in the Caucasian populations is associated with variations in several genes, including neuronal growth regulator 1…”
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Variations in the FTO gene are associated with severe obesity in the Japanese by Hotta, Kikuko, Nakata, Yoshio, Matsuo, Tomoaki, Kamohara, Seika, Kotani, Kazuaki, Komatsu, Ryoya, Itoh, Naoto, Mineo, Ikuo, Wada, Jun, Masuzaki, Hiroaki, Yoneda, Masato, Nakajima, Atsushi, Miyazaki, Shigeru, Tokunaga, Katsuto, Kawamoto, Manabu, Funahashi, Tohru, Hamaguchi, Kazuyuki, Yamada, Kentaro, Hanafusa, Toshiaki, Oikawa, Shinichi, Yoshimatsu, Hironobu, Nakao, Kazuwa, Sakata, Toshiie, Matsuzawa, Yuji, Tanaka, Kiyoji, Kamatani, Naoyuki, Nakamura, Yusuke

“…Variations in the fat-mass and obesity-associated gene (FTO) are associated with the obesity phenotype in many Caucasian populations. This association with the…”
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Rebamipide, an Amino Acid Analog of 2(1H)-Quinolinone, Inhibits the Formation of Human Osteoclasts by Yamanaka, Hisashi, Kawamoto, Manabu, Yago, Toru, Kobashigawa, Tsuyoshi, Nanke, Yuki, Kotake, Shigeru

“…Objectives. Drug repositioning or drug reprofiling (DR) has recently been growing in importance. DR has a significant advantage over traditional drug…”
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Tacrolimus potently inhibits human osteoclastogenesis induced by IL-17 from human monocytes alone and suppresses human Th17 differentiation by Yago, Toru, Nanke, Yuki, Kawamoto, Manabu, Yamanaka, Hisashi, Kotake, Shigeru

“…► Tacrolimus inhibited IL-17-induced osteoclastogenesis and Th17 differentiation. Tacrolimus (FK506, Prograf®) is an orally available, T cell specific and…”
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Intracellular IL-1α-Binding Proteins Contribute to Biological Functions of Endogenous IL-1α in Systemic Sclerosis Fibroblasts by Kawaguchi, Yasushi, Nishimagi, Emi, Tochimoto, Akiko, Kawamoto, Manabu, Katsumata, Yasuhiro, Soejima, Makoto, Kanno, Tokiko, Kamatani, Naoyuki, Hara, Masako

“…The aberrant production of precursor IL-1α (pre-IL-1α) in skin fibroblasts that are derived from systemic sclerosis (SSc) is associated with the induction of…”
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Clinical usefulness of anti-M-type phospholipase-A-receptor antibodies in patients with membranous nephropathy and the comparison of three quantification methods by Katsumata, Yasuhiro, Okamoto, Yuko, Moriyama, Takahito, Moriyama, Rina, Kawamoto, Manabu, Hanaoka, Masanori, Uchida, Keiko, Nitta, Kosaku, Harigai, Masayoshi

“…Associations between anti-M-type phospholipase A2 receptor (PLA2R) antibodies and disease activity and prognosis have been suggested in primary membranous…”
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Voltage-dependent anion channels (VDACs, porin) expressed in the plasma membrane regulate the differentiation and function of human osteoclasts by Kotake, Shigeru, Yago, Toru, Kawamoto, Manabu, Nanke, Yuki

“…Fewer molecules have been identified on human than murine osteoclasts, the former differing from murine osteoclasts in many ways. We show that…”
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Activation of the Activin A-ALK-Smad pathway in systemic sclerosis by Takagi, Kae, Kawaguchi, Yasushi, Kawamoto, Manabu, Ota, Yuko, Tochimoto, Akiko, Gono, Takahisa, Katsumata, Yasuhiro, Takagi, Masatoshi, Hara, Masako, Yamanaka, Hisashi

“…Abstract Systemic sclerosis (SSc) is a chronic disease of unknown etiology that is characterized by multiple tissue fibrosis. Transforming Growth Factor-beta…”
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Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects by Saito, Akira, Kawamoto, Manabu, Kamatani, Naoyuki

“…With dense single-nucleotide polymorphism (SNP) maps for 199 drug-related genes, we examined associations between 4190 SNPs and 38 commonly measured…”
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Ethnic Differences of two Non-synonymous Single Nucleotide Polymorphisms in CDA Gene by Sugiyama, Emiko, Lee, Su-Jun, Lee, Sang Seop, Kim, Woo-Young, Kim, Su-Ryang, Tohkin, Masahiro, Hasegawa, Ryuichi, Okuda, Haruhiro, Kawamoto, Manabu, Kamatani, Naoyuki, Sawada, Jun-ichi, Kaniwa, Nahoko, Saito, Yoshiro, Shin, Jae-Gook

“…Cytidine deaminase, encoded by the CDA gene, catalyzes anti-cancer drugs gemcitabine and ara-C into their respective inactive metabolites. In CDA, two…”
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Interferon-induced helicase (IFIH1) polymorphism with systemic lupus erythematosus and dermatomyositis/polymyositis by Gono, Takahisa, Kawaguchi, Yasushi, Sugiura, Tomoko, Furuya, Takefumi, Kawamoto, Manabu, Hanaoka, Masanori, Yamanaka, Hisashi

“…The aim of the present study was to evaluate whether the interferon-induced helicase ( IFIH1 ) Ala946Thr (rs1990760 A>G) polymorphism is associated with…”
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Contribution of single nucleotide polymorphisms of the IL1A gene to the cleavage of precursor IL-1α and its transcription activity by Kawaguchi, Yasushi, Tochimoto, Akiko, Hara, Masako, Kawamoto, Manabu, Sugiura, Tomoko, Saito, Seiji, Kamatani, Naoyuki

“…We previously demonstrated the association of IL1A gene single nucleotide polymorphisms (SNPs) with susceptibility to systemic sclerosis (SSc) patients. In…”
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Effects of NSAIDs on Differentiation and Function of Human and Murine Osteoclasts - Crucial 'Human Osteoclastology' by Kotake, Shigeru, Yago, Toru, Kawamoto, Manabu, Nanke, Yuki

“…Osteoclasts play a critical role in both normal bone metabolism and bone resorption in the joints of patients with rheumatoid arthritis. It has been reported…”
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Single nucleotide polymorphisms of CD244 gene predispose to renal and neuropsychiatric manifestations with systemic lupus erythematosus by Ota, Yuko, Kawaguchi, Yasushi, Takagi, Kae, Tochimoto, Akiko, Kawamoto, Manabu, Katsumata, Yasuhiro, Gono, Takahisa, Masuda, Ikuko, Ikari, Katsunori, Momohara, Shigeki, Yamanaka, Hisashi

“…The objective of this study was to explore the association of single nucleotide polymorphisms (SNPs) of the CD244 gene with several clinical features of…”
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Genetic Variations of the ABC Transporter Gene ABCB11 Encoding the Human Bile Salt Export Pump (BSEP) in a Japanese Population by Kim, Su-Ryang, Saito, Yoshiro, Itoda, Masaya, Maekawa, Keiko, Kawamoto, Manabu, Kamatani, Naoyuki, Ozawa, Shogo, Sawada, Jun-ichi

“…The bile sait export pump (BSEP) encoded by ABCB11 is located in the canalicular membrane of hepatocytes and mediates the secretion of numerous conjugated bile…”
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Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences by Maekawa, Keiko, Saeki, Mayumi, Saito, Yoshiro, Ozawa, Shogo, Kurose, Kouichi, Kaniwa, Nahoko, Kawamoto, Manabu, Kamatani, Naoyuki, Kato, Ken, Hamaguchi, Tetsuya, Yamada, Yasuhide, Shirao, Kuniaki, Shimada, Yasuhiro, Muto, Manabu, Doi, Toshihiko, Ohtsu, Atsushi, Yoshida, Teruhiko, Matsumura, Yasuhiro, Saijo, Nagahiro, Sawada, Jun-Ichi

“…Dihydropyrimidine dehydrogenase (DPD) is an inactivating and rate-limiting enzyme for 5-fluorouracil (5-FU), and its deficiency is associated with a risk for…”
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