Search Results - "Kawamori, R."

Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on progression of diabetic neuropathy and other microvascular complications: multivariate epidemiological analysis based on patient background factors and severity of diabetic neuropathy by Hotta, N., Kawamori, R., Fukuda, M., Shigeta, Y.

“…Diabet. Med. 29, 1529–1533 (2012) Aims  The goal of the study was to evaluate the efficacy of epalrestat, an aldose reductase inhibitor, on diabetic…”
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An Investigation of Water Diffusivity Changes along the Perivascular Space in Elderly Subjects with Hypertension by Kikuta, J, Kamagata, K, Takabayashi, K, Taoka, T, Yokota, H, Andica, C, Wada, A, Someya, Y, Tamura, Y, Kawamori, R, Watada, H, Naganawa, S, Aoki, S

“…Hypertension may be related to alterations of the glymphatic system, a waste metabolite drainage system in the brain. We aimed to investigate analysis along…”
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Effects of Arterial Stiffness on Cerebral WM Integrity in Older Adults: A Neurite Orientation Dispersion and Density Imaging and Magnetization Transfer Saturation Imaging Study by Kikuta, J, Kamagata, K, Abe, M, Andica, C, Saito, Y, Takabayashi, K, Uchida, W, Naito, H, Tabata, H, Wada, A, Tamura, Y, Kawamori, R, Watada, H, Aoki, S

“…Arterial stiffness is reported to be able to cause axonal demyelination or degeneration. The present study aimed to use advanced MR imaging techniques to…”
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Linagliptin monotherapy provides superior glycaemic control versus placebo or voglibose with comparable safety in Japanese patients with type 2 diabetes: a randomized, placebo and active comparator-controlled, double-blind study by Kawamori, R., Inagaki, N., Araki, E., Watada, H., Hayashi, N., Horie, Y., Sarashina, A., Gong, Y., von Eynatten, M., Woerle, H. J., Dugi, K. A.

“…Aims: To evaluate the efficacy and safety of linagliptin 5 and 10 mg vs. placebo and voglibose in Japanese patients with type 2 diabetes mellitus (T2DM)…”
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The IMPROVE study--a multinational, observational study in type 2 diabetes: baseline characteristics from eight national cohorts by Valensi, P, Benroubi, M, Borzi, V, Gumprecht, J, Kawamori, R, Shaban, J, Shah, S, Shestakova, M, Wenying, Y

“…The IMPROVE study is a multinational, open-label, non-randomised, 26-week observational study assessing the safety and effectiveness of biphasic insulin aspart…”
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Factors influencing initial choice of insulin therapy in a large international non-interventional study of people with type 2 diabetes by Freemantle, N., Balkau, B., Danchin, N., Wang, E., Marre, M., Vespasiani, G., Kawamori, R., Home, P. D.

“…Aim: To use baseline characteristics of the Cardiovascular Risk Evaluation in people with type 2 Diabetes on Insulin Therapy study population to identify…”
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Impaired insulin secretion in vivo but enhanced insulin secretion from isolated islets in pancreatic beta cell-specific vascular endothelial growth factor-A knock-out mice by Iwashita, N, Uchida, T, Choi, J. B, Azuma, K, Ogihara, T, Ferrara, N, Gerber, H, Kawamori, R, Inoue, M, Watada, H

“…Aims/hypothesis Endothelial cells are considered to be essential for normal pancreatic beta cell function. However, there have been no reports showing their…”
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Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells by CHOI, J. B, UCHINO, H, AZUMA, K, IWASHITA, N, TANAKA, Y, MOCHIZUKI, H, MIGITA, M, SHIMADA, T, KAWAMORI, R, WATADA, H

“…Bone marrow cells contain at least two distinct types of stem cells which are haematopoietic stem cells and mesenchymal stem cells. Both cells have the ability…”
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Initiating insulin therapy with, or switching existing insulin therapy to, biphasic insulin aspart 30/70 (NovoMix 30) in routine care: safety and effectiveness in patients with type 2 diabetes in the IMPROVE observational study by Valensi, P, Benroubi, M, Borzi, V, Gumprecht, J, Kawamori, R, Shaban, J, Shah, S, Shestakova, M, Wenying, Y

“…The IMPROVE observational study evaluated the safety profile and effectiveness of biphasic insulin aspart 30/70 (BIAsp 30) in patients with type 2 diabetes in…”
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Repetitive hypoglycaemia increases serum adrenaline and induces monocyte adhesion to the endothelium in rat thoracic aorta by Jin, W. L., Azuma, K., Mita, T., Goto, H., Kanazawa, A., Shimizu, T., Ikeda, F., Fujitani, Y., Hirose, T., Kawamori, R., Watada, H.

“…Aims/hypothesis Severe hypoglycaemia associated with diabetes management is a potential risk for cardiovascular diseases. However, the effect and mechanism of…”
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Vitamin D status and index representing the detrimental mechanical loading across the knee joint in end-stage knee osteoarthritis representing the detrimental mechanical loading across the knee joint in end-stage knee osteoarthritis by Kinoshita, M, Kaneko, H, Ishijima, M, Liz, L, Sadatsuki, R, Hada, S, Yusup, A, Arita, H, Shiozawa, J, Aoki, T, Tamura, Y, Kawamori, R, Kaneko, K

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Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population by Imamura, M., Iwata, M., Maegawa, H., Watada, H., Hirose, H., Tanaka, Y., Tobe, K., Kaku, K., Kashiwagi, A., Kawamori, R., Nakamura, Y., Maeda, S.

“…Aims/hypothesis Recently, rs10906115 in CDC123/CAMK1D , rs1359790 near SPRY2 , rs1436955 in C2CD4A/C2CD4B and rs10751301 in ODZ4 were identified as genetic…”
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Medial meniscus extrusion was associated with the clinical manifestation of the elderlies aged 70's without knee pain with Kellgren-Lawrence grade 2 of knee osteoarthritis by Aoki, T, Liu, L, Ishijima, M, Someya, Y, Kaneko, H, Sadatsuki, R, Hada, S, Yusup, A, Kinoshita, M, Arita, H, Shiozawa, J, Tamura, Y, Nagao, M, Takazawa, Y, Ikeda, H, Watada, H, Kawamori, R, Kaneko, K

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The lower ratio of the cartilage destruction and synthesis biomarkers is a risk for the radiographic medial knee joint space narrowing in men in early forties without knee osteoarthritis – A three years prospective observational study “sportology core study 1” by Liu, L, Ishijima, M, Kaneko, H, Sadatsuki, R, Hada, S, Yusup, A, Kinoshita, M, Arita, H, Shiozawa, J, Aoki, T, Tamura, Y, Someya, Y, Nagao, M, Takazawa, Y, Ikeda, H, Watada, H, Kawamori, R, Kaneko, K

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Long-term safety of linagliptin monotherapy in Japanese patients with type 2 diabetes by Araki, E., Kawamori, R., Inagaki, N., Watada, H., Hayashi, N., Horie, Y., Sarashina, A., Thiemann, S., von Eynatten, M., Dugi, K., Woerle, H.-J.

“…Aims In a phase III study conducted among Japanese patients with type 2 diabetes mellitus (T2DM), linagliptin 5 and 10 mg showed clinically meaningful…”
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Aldose reductase C-106T gene polymorphism is associated with diabetic retinopathy in Japanese patients with type 2 diabetes by Katakami, N, Kaneto, H, Takahara, M, Matsuoka, T.A, Imamura, K, Ishibashi, F, Kanda, T, Kawai, K, Osonoi, T, Matsuhisa, M, Kashiwagi, A, Kawamori, R, Shimomura, I, Yamasaki, Y

“…Abstract It is likely that the C allele of the polymorphism at position −106 in the promoter of aldose reductase gene, which codes a rate-limiting enzyme of…”
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Carotid intima-media thickness in Japanese type 2 diabetic subjects: predictors of progression and relationship with incident coronary heart disease by YAMASAKI, Y, KODAMA, M, NISHIZAWA, H, SAKAMOTO, K, MATSUHISA, M, KAJIMOTO, Y, KOSUGI, K, SHIMIZU, Y, KAWAMORI, R, HORI, M

“…Carotid intima-media thickness in Japanese type 2 diabetic subjects: predictors of progression and relationship with incident coronary heart disease. Y…”
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ELMO1 increases expression of extracellular matrix proteins and inhibits cell adhesion to ECMs by Shimazaki, A., Tanaka, Y., Shinosaki, T., Ikeda, M., Watada, H., Hirose, T., Kawamori, R., Maeda, S.

“…We have previously identified the engulfment and cell motility 1 (ELMO1) as a susceptibility gene for diabetic nephropathy. To elucidate the role of ELMO1 in…”
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Safety and effectiveness of biphasic insulin aspart 30/70 (NovoMix 30) when switching from human premix insulin in patients with type 2 diabetes: subgroup analysis from the 6-month IMPROVE observational study by Shah, S, Benroubi, M, Borzi, V, Gumprecht, J, Kawamori, R, Shaban, J, Shestakova, M, Wenying, Y, Valensi, P

“…IMPROVE is an open-label, multinational, non-randomised, 26-week observational study designed to evaluate the safety and effectiveness of biphasic insulin…”
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Intensification to biphasic insulin aspart 30/70 (BIAsp 30, NovoMix 30) can improve glycaemic control in patients treated with basal insulins: a subgroup analysis of the IMPROVE observational study by Gumprecht, J, Benroubi, M, Borzi, V, Kawamori, R, Shaban, J, Shah, S, Shestakova, M, Wenying, Y, Ligthelm, R, Valensi, P

“…The international IMPROVE observational study investigated the safety profile and effectiveness of biphasic insulin aspart 30/70 (BIAsp 30) in the routine…”
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