Individual HLAs influence immunological events in allogeneic stem cell transplantation from HLA-identical sibling donors

In allogeneic hematopoietic stem cell transplantation (allo-HSCT), the effects of patient and donor human leukocyte antigen (HLA) matching status on graft-versus-host disease (GVHD) have been extensively elucidated, but the effects of specific HLAs on acute GVHD remain unclear. Using data from a Jap...

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Published in:	Bone marrow transplantation (Basingstoke) Vol. 56; no. 3; pp. 646 - 654
Main Authors:	Morishima, Satoko, Fukuda, Takahiro, Doki, Noriko, Mori, Takehiko, Onizuka, Makoto, Kawakita, Toshihiro, Kato, Chiaki, Ozawa, Yukiyasu, Tanaka, Masatsugu, Kurokawa, Mineo, Kamimura, Tomohiko, Inoue, Masami, Tanaka, Junji, Ichinohe, Tatsuo, Atsuta, Yoshiko, Morishima, Yasuo
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-03-2021 Nature Publishing Group
Subjects:	692/308/2056 692/308/2171 Antigens Brothers and sisters Care and treatment Cell Biology Donors Genetic aspects Graft versus host reaction Health aspects Hematology Hematopoietic stem cells Histocompatibility antigen HLA Histocompatibility antigens HLA histocompatibility antigens Homografts Immunology Internal Medicine Leukemia Leukocytes Medicine Medicine & Public Health Myelodysplastic syndrome Myelodysplastic syndromes Patient outcomes Public Health Risk Risk factors Stem cell transplantation Stem Cells Transplantation Transplants Transplants & implants Japan
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Summary:	In allogeneic hematopoietic stem cell transplantation (allo-HSCT), the effects of patient and donor human leukocyte antigen (HLA) matching status on graft-versus-host disease (GVHD) have been extensively elucidated, but the effects of specific HLAs on acute GVHD remain unclear. Using data from a Japanese registry, we retrospectively analyzed 4392 patients with leukemia or myelodysplastic syndrome who received transplants from HLA-identical sibling donors to investigate the effects of HLAs on acute GVHD. From unbiased searches of HLA-A, -B, and -DR, HLA-B60 was significantly associated with an increased risk of grades II–IV acute GVHD (HR, 1.34; 95% CI, 1.13–1.59; P = 0.001). In contrast, HLA-B62 was significantly associated with a decreased risk of grades II–IV (HR, 0.73; 95% CI, 0.62–0.87; P < 0.001) and III–IV acute GVHD (HR, 0.63; 95% CI, 0.46–0.87; P = 0.005). The risk of leukemia relapse was significantly higher in HLA-B62-positive patients than in HLA-B62-negative patients (HR, 1.23; 95% CI, 1.05–1.43; P = 0.01). Both HLA-B60 and -B62 did not affect overall survival. The findings of this study may by implication suggest the possibility that the effects of specific HLAs on transplant outcomes may reflect inherent biological features, and thus consideration of specific HLAs may be helpful to predict transplant outcomes.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0268-3369 1476-5365
DOI:	10.1038/s41409-020-01070-3