Search Results - "Kawakibi, Abed Rahman"

ONC201 and imipridones: Anti-cancer compounds with clinical efficacy by Prabhu, Varun Vijay, Morrow, Sara, Rahman Kawakibi, Abed, Zhou, Lanlan, Ralff, Marie, Ray, Jocelyn, Jhaveri, Aakash, Ferrarini, Isacco, Lee, Young, Parker, Cassandra, Zhang, Yiqun, Borsuk, Robyn, Chang, Wen-I, Honeyman, Joshua N., Tavora, Fabio, Carneiro, Benedito, Raufi, Alexander, Huntington, Kelsey, Carlsen, Lindsey, Louie, Anna, Safran, Howard, Seyhan, Attila A., Tarapore, Rohinton S., Schalop, Lee, Stogniew, Martin, Allen, Joshua E., Oster, Wolfgang, El-Deiry, Wafik S.

“…ONC201 was originally discovered as TNF-Related Apoptosis Inducing Ligand (TRAIL)-inducing compound TIC10. ONC201 appears to act as a selective antagonist of…”
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Serial H3K27M cell-free tumor DNA (cf-tDNA) tracking predicts ONC201 treatment response and progression in diffuse midline glioma by Cantor, Evan, Wierzbicki, Kyle, Tarapore, Rohinton S, Ravi, Karthik, Thomas, Chase, Cartaxo, Rodrigo, Nand Yadav, Viveka, Ravindran, Ramya, Bruzek, Amy K, Wadden, Jack, John, Vishal, May Babila, Clarissa, Cummings, Jessica R, Rahman Kawakibi, Abed, Ji, Sunjong, Ramos, Johanna, Paul, Alyssa, Walling, Dustin, Leonard, Marcia, Robertson, Patricia, Franson, Andrea, Mody, Rajen, Garton, Hugh J L, Venneti, Sriram, Odia, Yazmin, Kline, Cassie, Vitanza, Nicholas A, Khatua, Soumen, Mueller, Sabine, Allen, Joshua E, Gardner, Sharon L, Koschmann, Carl

“…Abstract Background Diffuse Midline Glioma (DMG) with the H3K27M mutation is a lethal childhood brain cancer, with patients rarely surviving 2 years from…”
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Targeting and Therapeutic Monitoring of H3K27M-Mutant Glioma by Wierzbicki, Kyle, Ravi, Karthik, Franson, Andrea, Bruzek, Amy, Cantor, Evan, Harris, Micah, Homan, Morgan J., Marini, Bernard L., Kawakibi, Abed Rahman, Ravindran, Ramya, Teodoro, Rodrigo, Yadav, Viveka Nand, Koschmann, Carl

“…Purpose of Review H3K27M is a frequent histone mutation within diffuse midline gliomas and is associated with a dismal prognosis, so much so that the 2016 CNS…”
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Correction to: Targeting and Therapeutic Monitoring of H3K27M-Mutant Glioma by Wierzbicki, Kyle, Ravi, Karthik, Franson, Andrea, Bruzek, Amy, Cantor, Evan, Harris, Micah, Homan, Morgan J., Marini, Bernard L., Kawakibi, Abed Rahman, Ravindran, Ramya, Teodoro, Rodrigo, Yadav, Viveka Nand, Koschmann, Carl

“…The original version of this review article unfortunately contained a mistake in the author group section…”
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Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways by Venneti, Sriram, Kawakibi, Abed Rahman, Ji, Sunjong, Waszak, Sebastian M, Sweha, Stefan R, Mota, Mateus, Pun, Matthew, Deogharkar, Akash, Chung, Chan, Tarapore, Rohinton S, Ramage, Samuel, Chi, Andrew, Wen, Patrick Y, Arrillaga-Romany, Isabel, Batchelor, Tracy T, Butowski, Nicholas A, Sumrall, Ashley, Shonka, Nicole, Harrison, Rebecca A, de Groot, John, Mehta, Minesh, Hall, Matthew D, Daghistani, Doured, Cloughesy, Timothy F, Ellingson, Benjamin M, Beccaria, Kevin, Varlet, Pascale, Kim, Michelle M, Umemura, Yoshie, Garton, Hugh, Franson, Andrea, Schwartz, Jonathan, Jain, Rajan, Kachman, Maureen, Baum, Heidi, Burant, Charles F, Mottl, Sophie L, Cartaxo, Rodrigo T, John, Vishal, Messinger, Dana, Qin, Tingting, Peterson, Erik, Sajjakulnukit, Peter, Ravi, Karthik, Waugh, Alyssa, Walling, Dustin, Ding, Yujie, Xia, Ziyun, Schwendeman, Anna, Hawes, Debra, Yang, Fusheng, Judkins, Alexander R, Wahl, Daniel, Lyssiotis, Costas A, de la Nava, Daniel, Alonso, Marta M, Eze, Augustine, Spitzer, Jasper, Schmidt, Susanne V, Duchatel, Ryan J, Dun, Matthew D, Cain, Jason E, Jiang, Li, Stopka, Sylwia A, Baquer, Gerard, Regan, Michael S, Filbin, Mariella G, Agar, Nathalie Y R, Zhao, Lili, Kumar-Sinha, Chandan, Mody, Rajen, Chinnaiyan, Arul, Kurokawa, Ryo, Pratt, Drew, Yadav, Viveka N, Grill, Jacques, Kline, Cassie, Mueller, Sabine, Resnick, Adam, Nazarian, Javad, Allen, Joshua E, Odia, Yazmin, Gardner, Sharon L, Koschmann, Carl

“…Patients with H3K27M-mutant diffuse midline glioma (DMG) have no proven effective therapies. ONC201 has recently demonstrated efficacy in these patients, but…”
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Perceived Barriers to the De-implementation of Routine Preoperative History & Physicals Preceding Low-Risk Ambulatory Procedures: A Qualitative Study of Surgeon Perspectives by Baskin, Alison S., Mansour, Alexandra I., Kawakibi, Abed Rahman, Das, Porag Jeet, Rios, Anthony E., Miller, Jacquelyn, Cuttitta, Anthony, Lahti, Hannah, Dossett, Lesly A.

“…For patients undergoing surgery at an Ambulatory Surgical Center, recent changes to Centers for Medicare and Medicaid Services policy allow for the omission of…”
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EXTH-71. IND-ENABLING CHARACTERIZATION OF ONC206 AS THE NEXT BITOPIC DRD2 ANTAGONIST FOR NEURO-ONCOLOGY by Prabhu, Varun, Rahman Kawakibi, Abed, Madhukar, Neel, Garnett, Mathew, McDermott, Ultan, Benes, Cyril, Wechsler-Reya, Robert, Elemento, Olivier, Stogniew, Martin, Oster, Wolfgang, DeMorrow, Sharon, Allen, Joshua

“…Abstract ONC201 is the first clinical bitopic antagonist of DRD2, an oncogenic receptor in brain and neuroendocrine tumors. ONC206, a derivative of ONC201 that…”
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TMET-02. CLINICAL EFFICACY OF ONC201 IN H3K27M-MUTANT DIFFUSE MIDLINE GLIOMAS IS DRIVEN BY DISRUPTION OF INTEGRATED METABOLIC AND EPIGENETIC PATHWAYS by Venneti, Sriram, Kawakibi, Abed Rahman, Ji, Sunjong, Waszak, Sebastian, Sweha, Stefan, Mota, Mateus, Pun, Matthew, Deogharkar, Akash, Chung, Chan, Tarapore, Rohinton, Ramage, Samuel, Wen, Patrick, Arrillaga-Romany, Isabel, Garton, Hugh, Franson, Andrea, Schwartz, Jonathan, Jain, Rajan, Mottl, Sophie, Cartaxo, Rodrigo, John, Vishal, Messinger, Dana, Qin, Tingting, Peterson, Erik, Sajjakulnukit, Peter, Judkins, Alexander, Wahl, Daniel, Lyssiotis, Costas, de la Nava, Daniel, Alonso, Martha, Duchatel, Ryan, Dun, Matthew, Cain, Jason, Jiang, Li, Filbin, Mariella, Zhao, Lili, Kumar-Sinha, Chandan, Mody, Rajen, Chinnaiyan, Arul, Kurokawa, Ryo, Pratt, Drew, Yadav, Viveka, Grill, Jacques, Kline, Cassie, Mueller, Sabine, Resnick, Adam, Nazarian, Javad, Allen, Joshua, Odia, Yazmin, Gardner, Sharon, Koschmann, Carl

“…Abstract H3K27M-mutant diffuse midline glioma (DMG) patients have no proven effective therapies beyond radiation. ONC201, a mitochondrial protease ClpP…”
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Abstract 2749: Defining structure activity relationships for GPCR engagement and anti-cancer efficacy of imipridone small molecules by Prabhu, Varun V., Kawakibi, Abed Rahman, Madhukar, Neel S., Anantharaman, Lakshmi, Deacon, Sean, Charter, Neil S., Garnett, Mathew J., McDermott, Ultan, Benes, Cyril H., Oster, Wolfgang, Elemento, Olivier, Stogniew, Martin, Allen, Joshua E.

“…Abstract G protein-coupled receptors (GPCRs) represent the most widely exploited superfamily of drug targets for FDA-approved therapies for many diseases,…”
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EXTH-74. IND-ENABLING CHARACTERIZATION OF DUAL DRD2- AND ClpP-TARGETING AGENT ONC206 AS THE NEXT IMIPRIDONE FOR CLINICAL NEURO-ONCOLOGY by Prabhu, Varun, Morrow, Sara, Kawakibi, Abed Rahman, Jitkova, Yulia, Jung, Jinkyu, Madhukar, Neel, Garnett, Mathew, McDermott, Ultan, Benes, Cyril, Wechsler-Reya, Robert, Elemento, Olivier, DeMorrow, Sharon, Schimmer, Aaron, Stogniew, Martin, Theeler, Brett, Gilbert, Mark, Allen, Joshua

“…Abstract ONC201 is the first bitopic antagonist of dopamine receptor D2 (DRD2) and allosteric mitochondrial protease ClpP agonist, that is well tolerated and…”
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DDRE-33. MOLECULAR DIFFERENTIATION OF IMIPRIDONES ONC201 AND ONC206 by Prabhu, Varun, Cuoco, Caroline, Jung, Jinkyu, Morrow, Sara, Kawakibi, Abed Rahman, Willette, Blair, Day, Marilyn, Anantharaman, Lakshmi, Charter, Neil, Rucker, Joseph, Doranz, Benjamin, Basken, Joel, Stogniew, Martin, Gilbert, Mark, Free, R, Sibley, David, Allen, Joshua

“…Abstract ONC201 is the first bitopic antagonist of dopamine receptor D2 (DRD2) and agonist of ClpP in oncology. In clinical trials, the small molecule has…”
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Clinical efficacy of ONC201 in thalamic H3 K27M-mutant glioma by Kawakibi, Abed Rahman, Tarapore, Rohinton, Gardner, Sharon L., Kurz, Sylvia Christine, Wen, Patrick Y., Arrillaga-Romany, Isabel, Batchelor, Tracy, Butowski, Nicholas A., Sumrall, Ashley Love, Shonka, Nicole A., Harrison, Rebecca A., De Groot, John Frederick, Mehta, Minesh P., Odia, Yazmin, Hall, Matthew David, Cloughesy, Timothy Francis, Ellingson, Benjamin M., Umemura, Yoshie, Allen, Joshua E., Koschmann, Carl Johannes

“…Abstract only 3617 Background: Diffuse midline gliomas, H3 K27M-mutant are associated with a poor prognosis compared to H3 wild-type gliomas and have no…”
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BIOM-28. SERIAL PLASMA AND CSF CELL-FREE TUMOR DNA (cf-tDNA) TRACKING IN DIFFUSE MIDLINE GLIOMA PATIENTS UNDERGOING TREATMENT WITH ONC201 by Cantor, Evan, Wierzbicki, Kyle, Tarapore, Rohinton, Ravi, Karthik, Wadden, Jack, Babilla, Clarissa, Thomas, Chase, Cartaxo, Rodrigo, Yadav, Vivek Anand, Ravindran, Ramya, Bruzek, Amy K, Cummings, Jessica, Kawakibi, Abed Rahman, Ji, Sunjong, Paul, Alyssa, Wolfe, Ian, Leonard, Marcia, Robertson, Patricia, Franson, Andrea, Mody, Rajen, Garton, Hugh, Odia, Yazmin, Kline, Cassie, Vitanza, Nicholas, Khatua, Soumen, Allen, Joshua, Mueller, Sabine, Gardner, Sharon, Koschmann, Carl

“…Abstract Diffuse midline glioma (DMG) with H3K27M mutation is a lethal childhood brain cancer, with limited means of monitoring beyond serial MRI scans. We…”
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CTNI-61. CLINICAL EFFICACY AND PREDICTIVE BIOMARKERS OF ONC201 IN H3K27M-MUTANT DIFFUSE MIDLINE GLIOMA by Kawakibi, Abed Rahman, Tarapore, Rohinton, Gardner, Sharon, Chi, Andrew, Kurz, Sylvia, Wen, Patrick Y, Arrillaga-Romany, Isabel, Batchelor, Tracy, Butowski, Nicholas, Sumrall, Ashley, Shonka, Nicole, Harrison, Rebecca, DeGroot, John, Mehta, Minesh, Odia, Yazmin, Hall, Matthew, Daghistani, Doured, Cloughesy, Timothy, Ellingson, Benjamin, Kim, Michelle, Umemura, Yoshie, Garton, Hugh, Franson, Andrea, Schwartz, Jonathan, Li, Sunjong, Cartaxo, Rodrigo, Ravi, Karthik, Cantor, Evan, Cummings, Jessica, Paul, Alyssa, Walling, Dustin, Dun, Matthew, Cain, Jason, Li, Jiang, Filbin, Mariella, Zhao, Lili, Kumar-Sinha, Chandan, Mody, Rajen, Chinnaiyan, Arul, Kurokawa, Ryo, Pratt, Drew, Venneti, Sriram, Grill, Jacques, Kline, Cassie, Mueller, Sabine, Resnick, Adam C, Nazarian, Javad, Waszak, Sebastian, Allen, Joshua E, Koschmann, Carl

“…Abstract Patients with H3K27M-mutated diffuse midline glioma (DMG) have no proven effective therapies beyond radiation. ONC201, a DRD2 antagonist and…”
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DDIS-20. IMIPRIDONE STRUCTURE ACTIVITY RELATIONSHIP UNCOVERS ONC206 AS THE NEXT BITOPIC DRD2 ANTAGONIST FOR ONCOLOGY WITH DIFFERENTIATED RECEPTOR PHARMACOLOGY by Prabhu, Varun, Cuoco, Caroline, Jung, Jinkyu, Rahman Kawakibi, Abed, Willette, Blair, Day, Marilyn, Anantharaman, Lakshmi, Charter, Neil, Rucker, Joseph, Doranz, Benjamin, Oster, Wolfgang, Stogniew, Martin, Gilbert, Mark, Benjamin Free, R, Sibley, David, Allen, Joshua

“…Abstract ONC201 is the first bitopic antagonist of dopamine receptor D2 (DRD2) in oncology clinical trials, which have shown that the small molecule is well…”
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Abstract 3877: IND-enabling characterization of DRD2/3 imipridone antagonist ONC206 for oncology by Prabhu, Varun V., Kawakibi, Abed Rahman, Madhukar, Neel, Garnett, Mathew J., McDermott, Ultan, Benes, Cyril H., Anantharaman, Lakshmi, Charter, Neil, Deacon, Sean, VanEngelenburg, Alexander, Rucker, Joseph B., Doranz, Benjamin J., Rusert, Jessica, Wechsler-Reya, Robert, Elemento, Olivier, Stogniew, Martin, Oster, Wolfgang, DeMorrow, Sharon, Free, R. Benjamin, Sibley, David R., Allen, Joshua E.

“…Abstract Dopamine receptor D2 (DRD2) is a G protein-coupled receptor that is overexpressed and critical for survival in several cancers. ONC201, an imipridone…”
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HGG-18. CLINICAL EFFICACY OF ONC201 IN THALAMIC H3 K27M-MUTANT GLIOMA by Kawakibi, Abed Rahman, Tarapore, Rohinton S, Gardner, Sharon, Chi, Andrew, Kurz, Sylvia, Wen, Patrick Y, Arrillaga-Romany, Isabel, Batchelor, Tracy T, Butowski, Nicholas A, Sumrall, Ashley, Shonka, Nicole, Harrison, Rebecca, DeGroot, John, Mehta, Minesh, Odia, Yazmin, Hall, Matthew D, Daghistani, Doured, Cloughesy, Timothy F, Ellingson, Benjamin M, Umemura, Yoshie, Schwartz, Jonathan, Yadav, Vivekanand, Cartaxo, Rodrigo, Siada, Ruby, Miklja, Zachary, Bruzek, Amy, Cantor, Evan, Wierzbicki, Kyle, Paul, Alyssa, Wolfe, Ian, Leaoard, Marcia, Garton, Hugh, Mody, Rajen, Robertson, Patricia L, Lu, Guangrong, Merdinger, Krystal, Venneti, Sriram, Oster, Wolfgang, Allen, Joshua E, Koschmann, Carl

“…Abstract ONC201, a bitopic DRD2 antagonist and allosteric ClpP agonist, has shown encouraging efficacy in H3 K27M-mutant glioma. Given that the thalamus has…”
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CTNI-17. CLINICAL EFFICACY AND PREDICTIVE BIOMARKERS OF ONC201 IN H3 K27M-MUTANT DIFFUSE MIDLINE GLIOMA by Rahman Kawakibi, Abed, Tarapore, Rohinton S, Gardner, Sharon, Thomas, Chase, Cartaxo, Rodrigo, Yadav, Viveka Nand, Chi, Andrew, Kurz, Sylvia, Wen, Patrick, Arrillaga-Romany, Isabel, Batchelor, Tracy, Butowski, Nicholas, Sumrall, Ashley, Shonka, Nicole, Harrison, Rebecca, de Groot, John, Mehta, Minesh, Odia, Yazmin, Hall, Matthew, Daghistani, Doured, Cloughesy, Timothy, Ellingson, Benjamin, Umemura, Yoshie, Garton, Hugh, Franson, Andrea, Robertson, Patricia, Schwartz, Jonathan, Cantor, Evan, Miklja, Zachary, Mullan, Brendan, Bruzek, Amy, Siada, Ruby, Cummings, Jessica, Paul, Alyssa, Wolfe, Ian, Jiang, Li, Filbin, Mariella, Vats, Pankaj, Kumar-Sinha, Chandan, Mody, Rajen, Chinnaiyan, Arul, Venneti, Sriram, Lu, Guangrong, Mueller, Sabine, Martinez, Daniel, Resnick, Adam, Nazarian, Javad, Waszak, Sebastian, Allen, Joshua, Koschmann, Carl

“…Abstract Patients with diffuse midline glioma (DMG) harboring H3 K27M mutation rarely survive longer than two years and have no proven therapies following…”
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PDCT-12. CLINICAL EFFICACY OF ONC201 IN THALAMIC H3 K27M-MUTANT GLIOMA by Rahman Kawakibi, Abed, Gardner, Sharon, Chi, Andrew, Kurz, Sylvia, Wen, Patrick, Arrillaga-Romany, Isabel, Batchelor, Tracy, Butowski, Nicholas, Sumrall, Ashley, Shonka, Nicole, Harrison, Rebecca, DeGroot, John, Mehta, Minesh, Odia, Yazmin, Hall, Matthew, Daghistani, Doured, Cloughesy, Timothy, Ellingson, Benjamin, Umemura, Yoshie, Schwartz, Jonathan, Yadav, Vivekanand, Cartaxo, Rodrigo, Miklja, Zachary, Bruzek, Amy, Siada, Ruby, Mullan, Brendan, Stallard, Stefanie, Muruganand, Ashwath, Wierzbicki, Kyle, Paul, Alyssa, Wolfe, Ian, Kumar-Sinha, Chandan, Marini, Bernard, Leonard, Marcia, Garton, Hugh, Mody, Rajen, Robertson, Patricia, Merdinger, Krystal, Tarapore, Rohinton, Oster, Wolfgang, Allen, Joshua, Koschmann, Carl

“…Abstract ONC201, the first bitopic DRD2 antagonist for clinical oncology, has shown efficacy in H3 K27M-mutant glioma. We performed an integrated preclinical…”
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