Search Results - "Kawai, Tatsuo"

Adipose tissue inflammation and metabolic dysfunction in obesity by Kawai, Tatsuo, Autieri, Michael V, Scalia, Rosario

“…Several lines of preclinical and clinical research have confirmed that chronic low-grade inflammation of adipose tissue is mechanistically linked to metabolic…”
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Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology by Forrester, Steven J, Booz, George W, Sigmund, Curt D, Coffman, Thomas M, Kawai, Tatsuo, Rizzo, Victor, Scalia, Rosario, Eguchi, Satoru

“…The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology and pathophysiology. However, many of the signaling mechanisms have…”
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HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression by Kawai, Tatsuo, Sachs, David H, Sykes, Megan, Cosimi, A. Benedict

“…To the Editor: We previously reported results of our study of combined kidney and bone marrow transplantation without maintenance immunosuppression. We…”
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Contribution of ADAM17 and related ADAMs in cardiovascular diseases by Kawai, Tatsuo, Elliott, Katherine J., Scalia, Rosario, Eguchi, Satoru

“…A disintegrin and metalloproteases (ADAMs) are key mediators of cell signaling by ectodomain shedding of various growth factors, cytokines, receptors and…”
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AT1 receptor signaling pathways in the cardiovascular system by Kawai, Tatsuo, Forrester, Steven J., O’Brien, Shannon, Baggett, Ariele, Rizzo, Victor, Eguchi, Satoru

“…The importance of the renin angiotensin aldosterone system in cardiovascular physiology and pathophysiology has been well described whereas the detailed…”
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Clinical trials for renal allograft tolerance induction through combined hematopoietic stem cell transplantation: A narrative review by Hotta, Kiyohiko, Hirose, Takayuki, Kawai, Tatsuo

“…During the last four decades, development of effective immunosuppressants has significantly improved short‐term results of organ transplantation. However,…”
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Epidermal Growth Factor Receptor Transactivation: Mechanisms, Pathophysiology, and Potential Therapies in the Cardiovascular System by Forrester, Steven J, Kawai, Tatsuo, O'Brien, Shannon, Thomas, Walter, Harris, Raymond C, Eguchi, Satoru

“…Epidermal growth factor receptor (EGFR) activation impacts the physiology and pathophysiology of the cardiovascular system, and inhibition of EGFR activity is…”
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Targeting mitochondrial fission as a potential therapeutic for abdominal aortic aneurysm by Cooper, Hannah A, Cicalese, Stephanie, Preston, Kyle J, Kawai, Tatsuo, Okuno, Keisuke, Choi, Eric T, Kasahara, Shingo, Uchida, Haruhito A, Otaka, Nozomu, Scalia, Rosario, Rizzo, Victor, Eguchi, Satoru

“…Abstract Aims Angiotensin II (AngII) is a potential contributor to the development of abdominal aortic aneurysm (AAA). In aortic vascular smooth muscle cells…”
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Understanding Angiotensin II Type 1 Receptor Signaling in Vascular Pathophysiology by Eguchi, Satoru, Kawai, Tatsuo, Scalia, Rosario, Rizzo, Victor

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Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B by Congrains, Ada, Kamide, Kei, Oguro, Ryousuke, Yasuda, Osamu, Miyata, Keishi, Yamamoto, Eiichiro, Kawai, Tatsuo, Kusunoki, Hiroshi, Yamamoto, Hiroko, Takeya, Yasushi, Yamamoto, Koichi, Onishi, Miyuki, Sugimoto, Ken, Katsuya, Tomohiro, Awata, Nobuhisa, Ikebe, Kazunori, Gondo, Yasuyuki, Oike, Yuichi, Ohishi, Mitsuru, Rakugi, Hiromi

“…Abstract Genome-wide association studies (GWAS) have identified genetic variants contributing to the risk of cardiovascular disease (CVD) at the chromosome…”
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Establishment of an experimental model for MHC homo-to-hetero transplantation by Murata, Tomoki, Wada, Haruka, Otsuka, Ryo, Sasaki, Airi, Tsuji, Hyuma, Itoh, Mizuho, Eguchi, Nanami, Kawai, Tatsuo, Seino, Ken-ichiro

“…Preventing rejection is a major challenge in transplantation medicine, even when using pluripotent stem cell-derived grafts. In iPS cell (iPSC)-based…”
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The impact of visit-to-visit variability in blood pressure on renal function by Kawai, Tatsuo, Ohishi, Mitsuru, Kamide, Kei, Onishi, Miyuki, Takeya, Yasushi, Tatara, Yuji, Oguro, Ryosuke, Yamamoto, Koichi, Sugimoto, Ken, Rakugi, Hiromi

“…Hypertension is an important risk factor for cardiovascular diseases such as chronic kidney disease. It is still not fully understood how blood pressure…”
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Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II by Takayanagi, Takehiko, Forrester, Steven J, Kawai, Tatsuo, Obama, Takashi, Tsuji, Toshiyuki, Elliott, Katherine J, Nuti, Elisa, Rossello, Armando, Kwok, Hang Fai, Scalia, Rosario, Rizzo, Victor, Eguchi, Satoru

“…Angiotensin II (AngII) has been strongly implicated in hypertension and its complications. Evidence suggests the mechanisms by which AngII elevates blood…”
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RAGE ligands stimulate angiotensin II type I receptor (AT1) via RAGE/AT1 complex on the cell membrane by Yokoyama, Serina, Kawai, Tatsuo, Yamamoto, Koichi, Yibin, Huang, Yamamoto, Hiroko, Kakino, Akemi, Takeshita, Hikari, Nozato, Yoichi, Fujimoto, Taku, Hongyo, Kazuhiro, Takahashi, Toshimasa, Nakagami, Futoshi, Akasaka, Hiroshi, Takami, Yoichi, Takeya, Yasushi, Sugimoto, Ken, Sawamura, Tatsuya, Rakugi, Hiromi

“…The receptor for advanced glycation end-products (RAGE) and the G protein-coupled angiotensin II (AngII) type I receptor (AT1) play a central role in…”
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Role of Epidermal Growth Factor Receptor and Endoplasmic Reticulum Stress in Vascular Remodeling Induced by Angiotensin II by Takayanagi, Takehiko, Kawai, Tatsuo, Forrester, Steven J, Obama, Takashi, Tsuji, Toshiyuki, Fukuda, Yamato, Elliott, Katherine J, Tilley, Douglas G, Davisson, Robin L, Park, Joon-Young, Eguchi, Satoru

“…The mechanisms by which angiotensin II (AngII) elevates blood pressure and enhances end-organ damage seem to be distinct. However, the signal transduction…”
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HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression by Kawai, Tatsuo, Cosimi, A. Benedict, Spitzer, Thomas R, Tolkoff-Rubin, Nina, Suthanthiran, Manikkam, Saidman, Susan L, Shaffer, Juanita, Preffer, Frederic I, Ding, Ruchuang, Sharma, Vijay, Fishman, Jay A, Dey, Bimalangshu, Ko, Dicken S.C, Hertl, Martin, Goes, Nelson B, Wong, Waichi, Williams, Winfred W, Colvin, Robert B, Sykes, Megan, Sachs, David H

“…Five patients with end-stage renal disease received bone marrow and kidney transplants from HLA-mismatched living related donors. Transient hematopoietic…”
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Targeting Molecular Mechanism of Vascular Smooth Muscle Senescence Induced by Angiotensin II, A Potential Therapy via Senolytics and Senomorphics by Okuno, Keisuke, Cicalese, Stephanie, Elliott, Katherine J, Kawai, Tatsuo, Hashimoto, Tomoki, Eguchi, Satoru

“…Cardiovascular disease (CVD) is a prevalent issue in the global aging population. Premature vascular aging such as elevated arterial stiffness appears to be a…”
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Clinical and molecular correlation defines activity of physiological pathways in life-sustaining kidney xenotransplantation by Firl, Daniel J., Lassiter, Grace, Hirose, Takayuki, Policastro, Robert, D’Attilio, Ashley, Markmann, James F., Kawai, Tatsuo, Hall, Katherine C.

“…Porcine kidney xenotransplantation is accelerating towards clinical translation. However, despite the demonstrated ability of porcine kidneys to remove…”
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Caveolin-1 Deletion Prevents Hypertensive Vascular Remodeling Induced by Angiotensin II by Forrester, Steven J, Elliott, Katherine J, Kawai, Tatsuo, Obama, Takashi, Boyer, Michael J, Preston, Kyle J, Yan, Zhen, Eguchi, Satoru, Rizzo, Victor

“…It has been proposed that membrane microdomains, caveolae, in vascular cells are critical for signal transduction and downstream functions induced by…”
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The Fourth International Workshop on Clinical Transplant Tolerance by Issa, Fadi, Strober, Samuel, Leventhal, Joseph R., Kawai, Tatsuo, Kaufman, Dixon B., Levitsky, Josh, Sykes, Megan, Mas, Valeria, Wood, Kathryn J., Bridges, Nancy, Welniak, Lisbeth A., Chandran, Sindhu, Madsen, Joren C., Nickerson, Peter, Demetris, Anthony J., Lakkis, Fadi G., Thomson, Angus W.

“…The International Workshop on Clinical Transplant Tolerance is a biennial meeting that aims to provide an update on the progress of studies of…”
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