Search Results - "Kawahara, Tiara L.A."

CSN5 Isopeptidase Activity Links COP9 Signalosome Activation to Breast Cancer Progression by ADLER, Adam S, LITTLEPAGE, Laurie E, MEIHONG LIN, KAWAHARA, Tiara L. A, WONG, David J, WERB, Zena, CHANG, Howard Y

“…CSN5 has been implicated as a candidate oncogene in human breast cancers by genetic linkage with activation of the poor-prognosis, wound response gene…”
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SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin by Chua, Katrin F, Ried, Thomas, McCord, Ronald A, Michishita, Eriko, Kioi, Mitomu, Kusumoto, Rika, Barrett, J. Carl, Padilla-Nash, Hesed, Cheung, Peggie, Gozani, Or, Kawahara, Tiara L. A, Berber, Elisabeth, Chang, Howard Y, Damian, Mara, Bohr, Vilhelm A

“…The Sir2 deacetylase regulates chromatin silencing and lifespan in Saccharomyces cerevisiae. In mice, deficiency for the Sir2 family member SIRT6 leads to a…”
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Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment by Chan, Denise A., Kawahara, Tiara L.A., Sutphin, Patrick D., Chang, Howard Y., Chi, Jen-Tsan, Giaccia, Amato J.

“…Sustained angiogenesis, through either local sprouting (angiogenesis) or the recruitment of bone marrow-derived cells (BMDCs) (vasculogenesis), is essential to…”
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Reversal of aging by NFκB blockade by Adler, Adam S., Kawahara, Tiara L.A., Segal, Eran, Chang, Howard Y.

“…Genetic studies in model organisms such as yeast, worms, flies, and mice leading to lifespan extension suggest that longevity is subject to regulation. In…”
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Celastrols as Inducers of the Heat Shock Response and Cytoprotection[boxs] by Westerheide, Sandy D., Bosman, Joshua D., Mbadugha, Bessie N.A., Kawahara, Tiara L.A., Matsumoto, Gen, Kim, Soojin, Gu, Wenxin, Devlin, John P., Silverman, Richard B., Morimoto, Richard I.

“…Alterations in protein folding and the regulation of conformational states have become increasingly important to the functionality of key molecules in…”
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Dynamic chromatin localization of Sirt6 shapes stress- and aging-related transcriptional networks by Kawahara, Tiara L A, Rapicavoli, Nicole A, Wu, Angela R, Qu, Kun, Quake, Stephen R, Chang, Howard Y

“…The sirtuin Sirt6 is a NAD-dependent histone deacetylase that is implicated in gene regulation and lifespan control. Sirt6 can interact with the…”
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SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span by Kawahara, Tiara L.A., Michishita, Eriko, Adler, Adam S., Damian, Mara, Berber, Elisabeth, Lin, Meihong, McCord, Ron A., Ongaigui, Kristine C.L., Boxer, Lisa D., Chang, Howard Y., Chua, Katrin F.

“…Members of the sirtuin (SIRT) family of NAD-dependent deacetylases promote longevity in multiple organisms. Deficiency of mammalian SIRT6 leads to shortened…”
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Motif module map reveals enforcement of aging by continual NF-κB activity by Adler, Adam S., Sinha, Saurabh, Kawahara, Tiara L.A., Zhang, Jennifer Y., Segal, Eran, Chang, Howard Y.

“…Aging is characterized by specific alterations in gene expression, but their underlying mechanisms and functional consequences are not well understood. Here we…”
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Triptolide, an Inhibitor of the Human Heat Shock Response That Enhances Stress-induced Cell Death by Westerheide, Sandy D., Kawahara, Tiara L.A., Orton, Kai, Morimoto, Richard I.

“…Molecular chaperones, inducible by heat shock and a variety of other stresses, have critical roles in protein homeostasis, balancing cell stress with…”
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High throughput automated chromatin immunoprecipitation as a platform for drug screening and antibody validation by Wu, Angela R, Kawahara, Tiara L A, Rapicavoli, Nicole A, van Riggelen, Jan, Shroff, Emelyn H, Xu, Liwen, Felsher, Dean W, Chang, Howard Y, Quake, Stephen R

“…Chromatin immunoprecipitation (ChIP) is an assay for interrogating protein-DNA interactions that is increasingly being used for drug target discovery and…”
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Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death. VOLUME 281 (2006) PAGES 9616-9622 by Westerheide, Sandy D., Kawahara, Tiara L.A., Orton, Kai, Morimoto, Richard I.

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SIRT6 links histone H3 lysine 9 deacetylation to control of NF-κB dependent gene expression and organismal lifespan by Kawahara, Tiara L.A., Michishita, Eriko, Adler, Adam S., Damian, Mara, Berber, Elisabeth, Lin, Meihong, McCord, Ron A., Ongaigui, Kristine C.L., Boxer, Lisa D., Chang, Howard Y., Chua, Katrin F.

“…Members of the Sirtuin (SIRT) family of NAD+-dependent deacetylases promote longevity in multiple organisms. Deficiency of mammalian SIRT6 leads to shortened…”
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