Search Results - "Kawaguchi, Yoshimasa"

Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide by Akishiba, Misao, Takeuchi, Toshihide, Kawaguchi, Yoshimasa, Sakamoto, Kentarou, Yu, Hao-Hsin, Nakase, Ikuhiko, Takatani-Nakase, Tomoka, Madani, Fatemeh, Gräslund, Astrid, Futaki, Shiroh

“…One of the major obstacles in intracellular targeting using antibodies is their limited release from endosomes into the cytosol. Here we report an approach to…”
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Syndecan‑4 Is a Receptor for Clathrin-Mediated Endocytosis of Arginine-Rich Cell-Penetrating Peptides by Kawaguchi, Yoshimasa, Takeuchi, Toshihide, Kuwata, Keiko, Chiba, Junya, Hatanaka, Yasumaru, Nakase, Ikuhiko, Futaki, Shiroh

“…Arginine-rich cell-penetrating peptides (CPPs) such as Tat and oligoarginine peptides have been widely used as carriers for intracellular delivery of bioactive…”
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Modular Redesign of a Cationic Lytic Peptide To Promote the Endosomal Escape of Biomacromolecules by Azuma, Yusuke, Imai, Haruka, Kawaguchi, Yoshimasa, Nakase, Ikuhiko, Kimura, Hiroshi, Futaki, Shiroh

“…Endocytosis is an important route for the intracellular delivery of biomacromolecules, wherein their inefficient endosomal escape into the cytosol remains a…”
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Proteomics of appetite-regulating system influenced by menstrual cycle and intensive exercise in female athletes: a pilot study by Tanabe, Kazuhiro, Kamemoto, Kayoko, Kawaguchi, Yoshimasa, Fushimi, Kai, Wong, Sing Ying, Ikegami, Nodoka, Sakamaki-Sunaga, Mikako, Hayashi, Nobuhiro

“…Female athletes who endure intense training are at risk of developing the 'female athlete triad,' making energy intake management crucial. However, the…”
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Publisher Correction: Proteomics of appetite-regulating system influenced by menstrual cycle and intensive exercise in female athletes: a pilot study by Tanabe, Kazuhiro, Kamemoto, Kayoko, Kawaguchi, Yoshimasa, Fushimi, Kai, Wong, Sing Ying, Ikegami, Nodoka, Sakamaki-Sunaga, Mikako, Hayashi, Nobuhiro

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Structural Dissection of Epsin‐1 N‐Terminal Helical Peptide: The Role of Hydrophobic Residues in Modulating Membrane Curvature by Nishimura, Motoki, Kawaguchi, Yoshimasa, Kuroki, Kakeru, Nakagawa, Yuna, Masuda, Toshihiro, Sakai, Takayuki, Kawano, Kenichi, Hirose, Hisaaki, Imanishi, Miki, Takatani‐Nakase, Tomoka, Afonin, Sergii, Ulrich, Anne S., Futaki, Shiroh

“…Spatiotemporal structural alterations in cellular membranes are the hallmark of many vital processes. In these cellular events, the induction of local changes…”
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Cholesterol-Lowering Effect of Octaarginine-Appended β-Cyclodextrin in Npc1-Trap-CHO Cells by Motoyama, Keiichi, Nishiyama, Rena, Maeda, Yuki, Higashi, Taishi, Kawaguchi, Yoshimasa, Futaki, Shiroh, Ishitsuka, Yoichi, Kondo, Yuki, Irie, Tetsumi, Era, Takumi, Arima, Hidetoshi

“…Niemann–Pick disease type C (NPC) is an autosomal recessive lysosomal storage disorder, which is an inherited disease characterized by the accumulation of…”
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Finding ways into the cytosol: Peptide-mediated approaches for delivering proteins into cells by Kawaguchi, Yoshimasa, Futaki, Shiroh

“…The delivery of functional proteins, including antibodies, into cells opens up many opportunities to regulate cellular events, with significant implications…”
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An approach for the intracellular delivery of IgG via enzymatic ligation with a cell-permeable attenuated cationic amphiphilic lytic peptide by Kawaguchi, Yoshimasa, Terada, Sakahiro, Futaki, Shiroh

“…[Display omitted] Achieving effective intracellular delivery of therapeutic molecules such as antibodies (IgG) is a challenge in biomedical research and…”
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Cholesterol-Lowering Effect of Octaarginine-Appended β-Cyclodextrin in Npc1-Trap-CHO Cells by Keiichi Motoyamaa, Rena Nishiyamaa, Yuki Maedaa, b, c, Taishi Higashia, Yoshimasa Kawaguchid, Shiroh Futakid, Yoichi Ishitsukaa, Yuki Kondoa, Tetsumi Iriea, Takumi Erae, Hidetoshi Arimaa

“…Niemann-Pick disease type C (NPC) is an autosomal recessive lysosomal storage disorder, which is an inherited disease characterized by the accumulation of…”
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Liquid Droplet-Mediated Formulation of Lipid Nanoparticles Encapsulating Immunoglobulin G for Cytosolic Delivery by Hirai, Yusuke, Kawaguchi, Yoshimasa, Kasahara, Chisato, Hirose, Hisaaki, Futaki, Shiroh

“…Antibodies are promising biopharmaceuticals that offer new therapeutic options for diseases. Since antibodies are membrane impermeable, approaches that allow…”
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E3MPH16: An efficient endosomolytic peptide for intracellular protein delivery by Kawaguchi, Yoshimasa, Kawamura, Yuki, Hirose, Hisaaki, Kiyokawa, Megumi, Hirate, Momo, Hirata, Tsuyoshi, Higuchi, Yuriko, Futaki, Shiroh

“…To facilitate the introduction of proteins, such as antibodies, into cells, a variety of delivery peptides have been engineered. These peptides are typically…”
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CXCR4 Stimulates Macropinocytosis: Implications for Cellular Uptake of Arginine-Rich Cell-Penetrating Peptides and HIV by Tanaka, Gen, Nakase, Ikuhiko, Fukuda, Yasunori, Masuda, Ryo, Oishi, Shinya, Shimura, Kazuya, Kawaguchi, Yoshimasa, Takatani-Nakase, Tomoka, Langel, Ülo, Gräslund, Astrid, Okawa, Katsuya, Matsuoka, Masao, Fujii, Nobutaka, Hatanaka, Yasumaru, Futaki, Shiroh

“…CXCR4 is a coreceptor of HIV-1 infection in host cells. Through a photocrosslinking study to identify receptors involved in internalization of oligoarginine…”
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Polysaccharide-Based Coacervate Microgel Bearing Cationic Peptides That Achieve Dynamic Cell-Membrane Structure Alteration and Facile Cytosolic Infusion of IgGs by Michibata, Junya, Kawaguchi, Yoshimasa, Hirose, Hisaaki, Eguchi, Akiko, Deguchi, Sayaka, Takayama, Kazuo, Xu, Wei, Niidome, Takuro, Sasaki, Yoshihiro, Akiyoshi, Kazunari, Futaki, Shiroh

“…Conjugates of the biocompatible polysaccharide pullulan with a cell membrane permeabilizing peptide L17E (PL-L17Es) were prepared with the aim of producing…”
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Inkjet-Based Intracellular Delivery System that Effectively Utilizes Cell-Penetrating Peptides for Cytosolic Introduction of Biomacromolecules through the Cell Membrane by Omura, Mika, Morimoto, Kenta, Araki, Yurina, Hirose, Hisaaki, Kawaguchi, Yoshimasa, Kitayama, Yukiya, Goto, Yuto, Harada, Atsushi, Fujii, Ikuo, Takatani-Nakase, Tomoka, Futaki, Shiroh, Nakase, Ikuhiko

“…In the drug delivery system, the cytosolic delivery of biofunctional molecules such as enzymes and genes must achieve sophisticated activities in cells, and…”
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Stearylated Macropinocytosis-Inducing Peptides Facilitating the Cellular Uptake of Small Extracellular Vesicles by Nakagawa, Yuna, Arafiles, Jan Vincent V., Kawaguchi, Yoshimasa, Nakase, Ikuhiko, Hirose, Hisaaki, Futaki, Shiroh

“…Macropinocytosis is a form of endocytosis that allows massive uptake of extracellular materials and is a promising route for intracellular delivery of…”
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Dipicolylamine/Metal Complexes that Promote Direct Cell-Membrane Penetration of Octaarginine by Kawaguchi, Yoshimasa, Ise, Shoko, Azuma, Yusuke, Takeuchi, Toshihide, Kawano, Kenichi, Le, Toan Khanh, Ohkanda, Junko, Futaki, Shiroh

“…Marked promotion of membrane permeation of a cell-penetrating peptide, octaarginine (R8), was attained by attachment to a single 2,2′-dipicolylamine moiety…”
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Split luciferase-based estimation of cytosolic cargo concentration delivered intracellularly via attenuated cationic amphiphilic lytic peptides by Okano, Syusuke, Kawaguchi, Yoshimasa, Kawano, Kenichi, Hirose, Hisaaki, Imanishi, Miki, Futaki, Shiroh

“…[Display omitted] •Measurement of actual cytosolic concentrations aids design of effective cellular delivery methods.•A split-NanoLuc luciferase system to…”
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Grafting Hydrophobic Amino Acids Critical for Inhibition of Protein–Protein Interactions on a Cell-Penetrating Peptide Scaffold by Nagano, Yuki, Arafiles, Jan Vincent V, Kuwata, Keiko, Kawaguchi, Yoshimasa, Imanishi, Miki, Hirose, Hisaaki, Futaki, Shiroh

“…Stapled peptides are a promising class of conformationally restricted peptides for modulating protein–protein interactions (PPIs). However, the low membrane…”
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Identification of cellular proteins interacting with octaarginine (R8) cell-penetrating peptide by photo-crosslinking by Kawaguchi, Yoshimasa, Tanaka, Gen, Nakase, Ikuhiko, Imanishi, Miki, Chiba, Junya, Hatanaka, Yasumaru, Futaki, Shiroh

“…Octaarginine (R8) is a representative cell-penetrating peptide. Lanthionine synthetase component C-like protein 1 (LanCL1) was identified as a potential…”
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