Search Results - "Kawaguchi, Tsutomu"

Cytolytic Activity Score to Assess Anticancer Immunity in Colorectal Cancer by Narayanan, Sumana, Kawaguchi, Tsutomu, Yan, Li, Peng, Xuan, Qi, Qianya, Takabe, Kazuaki

“…Background Elevated tumor-infiltrating lymphocytes (TILs) within the tumor microenvironment is a known positive prognostic factor in colorectal cancer (CRC)…”
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Tumor Infiltrating Lymphocytes and Macrophages Improve Survival in Microsatellite Unstable Colorectal Cancer by Narayanan, Sumana, Kawaguchi, Tsutomu, Peng, Xuan, Qi, Qianya, Liu, Song, Yan, Li, Takabe, Kazuaki

“…Due to the loss of DNA repair mechanisms in colorectal cancer (CRC) with microsatellite instability (MSI), somatic mutations accumulate within DNA; making them…”
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Regulation of hypoxia‐inducible factor functions in the nucleus by sphingosine‐1‐phosphate by Hait, Nitai C., Maiti, Aparna, Xu, Pan, Qi, Qianya, Kawaguchi, Tsutomu, Okano, Maiko, Takabe, Kazuaki, Yan, Li, Luo, Cheng

“…Sphingosine kinase 2 (SphK2) is known to phosphorylate the nuclear sphingolipid metabolite to generate sphingosine‐1‐phosphate (S1P). Nuclear S1P is involved…”
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Clinical Relevance of microRNA Expressions in Breast Cancer Validated Using the Cancer Genome Atlas (TCGA) by Kim, Sara Y., Kawaguchi, Tsutomu, Yan, Li, Young, Jessica, Qi, Qianya, Takabe, Kazuaki

“…Background MicroRNAs (miRNAs) play a critical role in the carcinogenesis and progression of breast cancer. MiRNA-205 has tumor suppressive properties, whereas…”
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ASO Author Reflections: “From Computer to Bedside”: A New Translational Approach to Immunogenomics by Kawaguchi, Tsutomu, Narayanan, Sumana, Takabe, Kazuaki

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Plasma microRNA profiles: identification of miR-744 as a novel diagnostic and prognostic biomarker in pancreatic cancer by Miyamae, Mahito, Komatsu, Shuhei, Ichikawa, Daisuke, Kawaguchi, Tsutomu, Hirajima, Shoji, Okajima, Wataru, Ohashi, Takuma, Imamura, Taisuke, Konishi, Hirotaka, Shiozaki, Atsushi, Morimura, Ryo, Ikoma, Hisashi, Ochiai, Toshiya, Okamoto, Kazuma, Taniguchi, Hiroki, Otsuji, Eigo

“…Background: This study aims to explore novel microRNAs in plasma for screening cancer and predicting clinical outcomes in pancreatic cancer (PCa) patients…”
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Orthotopic Implantation Achieves Better Engraftment and Faster Growth Than Subcutaneous Implantation in Breast Cancer Patient-Derived Xenografts by Okano, Maiko, Oshi, Masanori, Butash, Ali, Okano, Ichiro, Saito, Katsuharu, Kawaguchi, Tsutomu, Nagahashi, Masayuki, Kono, Koji, Ohtake, Toru, Takabe, Kazuaki

“…Patient-Derived Xenograft (PDX) is now accepted as a murine model that better mimics human cancer when compared to a conventional cancer cell-line inoculation…”
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Tamoxifen sensitivity-related microRNA-342 is a useful biomarker for breast cancer survival by Young, Jessica, Kawaguchi, Tsutomu, Yan, Li, Qi, Qianya, Liu, Song, Takabe, Kazuaki

“…MicroRNAs (miRNAs) have emerged as one of the crucial regulators of cancer progression. Some miRNAs are reported to be related to the response of breast cancer…”
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Circulating MicroRNAs: A Next-Generation Clinical Biomarker for Digestive System Cancers by Kawaguchi, Tsutomu, Komatsu, Shuhei, Ichikawa, Daisuke, Tsujiura, Masahiro, Takeshita, Hiroki, Hirajima, Shoji, Miyamae, Mahito, Okajima, Wataru, Ohashi, Takuma, Imamura, Taisuke, Kiuchi, Jun, Konishi, Hirotaka, Shiozaki, Atsushi, Okamoto, Kazuma, Otsuji, Eigo

“…MicroRNAs (miRNAs) are short noncoding RNAs that post-transcriptionally regulate gene expression and play important roles in various physiological and…”
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Immune Cytolytic Activity for Comprehensive Understanding of Immune Landscape in Hepatocellular Carcinoma by Takahashi, Hideo, Kawaguchi, Tsutomu, Yan, Li, Peng, Xuan, Qi, Qianya, Morris, Luc G T, Chan, Timothy A, Tsung, Allan, Otsuji, Eigo, Takabe, Kazuaki

“…Cytolytic activity score (CYT), defined by granzyme A and perforin expression, is a useful marker for underlying immunity. We hypothesized that CYT-high…”
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Liquid biopsy in patients with pancreatic cancer: Circulating tumor cells and cell-free nucleic acids by Imamura, Taisuke, Komatsu, Shuhei, Ichikawa, Daisuke, Kawaguchi, Tsutomu, Miyamae, Mahito, Okajima, Wataru, Ohashi, Takuma, Arita, Tomohiro, Konishi, Hirotaka, Shiozaki, Atsushi, Morimura, Ryo, Ikoma, Hisashi, Okamoto, Kazuma, Otsuji, Eigo

“…Despite recent advances in surgical techniques and perioperative management, the prognosis of pancreatic cancer(PCa) remains extremely poor. To provide optimal…”
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Overexpression of TRIM44 contributes to malignant outcome in gastric carcinoma by Kashimoto, Kingo, Komatsu, Shuhei, Ichikawa, Daisuke, Arita, Tomohiro, Konishi, Hirotaka, Nagata, Hiroaki, Takeshita, Hiroki, Nishimura, Yukihisa, Hirajima, Shoji, Kawaguchi, Tsutomu, Shiozaki, Atsushi, Fujiwara, Hitoshi, Okamoto, Kazuma, Tsuda, Hitoshi, Otsuji, Eigo

“…Recent studies have shown that some members of the tripartite motif‐containing protein (TRIM) family, which is characterized by a conserved RING finger, B‐box,…”
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Extracellular acidity in tumor tissue upregulates programmed cell death ligand 1 expression on tumor cells via proton‐sensing G protein‐coupled receptors by Mori, Daichi, Tsujikawa, Takahiro, Sugiyama, Yoichiro, Kotani, Shin‐ichiro, Fuse, Shinya, Ohmura, Gaku, Arai, Akihito, Kawaguchi, Tsutomu, Hirano, Shigeru, Mazda, Osam, Kishida, Tsunao

“…Acidity in the tumor microenvironment has been reported to promote cancer growth and metastasis. In our study, we examined a potential relation between…”
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Validation of a claims‐based algorithm to identify cases of ulcerative colitis in Japan by Ogino, Haruei, Morikubo, Hiromu, Fukaura, Keita, Okui, Tasuku, Gardiner, Sean, Sugiyama, Naonobu, Yoshii, Noritoshi, Kawaguchi, Tsutomu, Chen, Haoqian, Nonnenmacher, Edward, Setoguchi, Soko, Nakashima, Naoki, Kobayashi, Taku

“…Background and Aim The prevalence of ulcerative colitis (UC) is increasing in Japan. Validated claims‐based definitions are required to investigate the…”
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Early signet ring cell carcinoma of the stomach is related to favorable prognosis and low incidence of lymph node metastasis by Imamura, Taisuke, Komatsu, Shuhei, Ichikawa, Daisuke, Kawaguchi, Tsutomu, Kosuga, Toshiyuki, Okamoto, Kazuma, Konishi, Hirotaka, Shiozaki, Atsushi, Fujiwara, Hitoshi, Otsuji, Eigo

“…Background The aim of this study was to evaluate the clinical characteristics of early signet ring cell carcinoma of the stomach (SRC) and to investigate the…”
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A systematic literature review of prognostic factors in patients with HR+/HER2− advanced breast cancer in Japan by Hattori, Masaya, Novick, Diego, Takaura, Kana, Tanizawa, Yoshinori, Kawaguchi, Tsutomu, Haro, Josep Maria, Monistrol-Mula, Anna, Onishi, Akira, Iwata, Hiroji

“…Abstract Background Breast cancer is the most prevalent cancer in women in Japan and the fifth in mortality. This systematic review summarized the evidence for…”
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Circulating miR-18a in plasma contributes to cancer detection and monitoring in patients with gastric cancer by Tsujiura, Masahiro, Komatsu, Shuhei, Ichikawa, Daisuke, Shiozaki, Atsushi, Konishi, Hirotaka, Takeshita, Hiroki, Moriumura, Ryo, Nagata, Hiroaki, Kawaguchi, Tsutomu, Hirajima, Shoji, Arita, Tomohiro, Fujiwara, Hitoshi, Okamoto, Kazuma, Otsuji, Eigo

“…Background Recently, circulating microRNAs have been reported to be stably detectable in plasma/serum and to function as potent non-invasive biomarkers in…”
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Japanese subgroup analysis of the phase 3 MONARCH 3 study of abemaciclib as initial therapy for patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer by Takahashi, Masato, Tokunaga, Eriko, Mori, Joji, Tanizawa, Yoshinori, van der Walt, Jan-Stefan, Kawaguchi, Tsutomu, Goetz, Matthew P., Toi, Masakazu

“…Background This was a Japanese subpopulation analysis of MONARCH 3, a randomized, double-blind, placebo-controlled phase 3 study of abemaciclib plus…”
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Circulating microRNA profiles in plasma: identification of miR-224 as a novel diagnostic biomarker in hepatocellular carcinoma independent of hepatic function by Okajima, Wataru, Komatsu, Shuhei, Ichikawa, Daisuke, Miyamae, Mahito, Kawaguchi, Tsutomu, Hirajima, Shoji, Ohashi, Takuma, Imamura, Taisuke, Kiuchi, Jun, Arita, Tomohiro, Konishi, Hirotaka, Shiozaki, Atsushi, Moriumura, Ryo, Ikoma, Hisashi, Okamoto, Kazuma, Taniguchi, Hiroki, Itoh, Yoshito, Otsuji, Eigo

“…This study was designed to identify novel microRNAs (miRNAs) in plasma for detecting and monitoring hepatocellular carcinoma (HCC), independent of hepatic…”
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Malignant potential in pancreatic neoplasm; new insights provided by circulating miR-223 in plasma by Komatsu, Shuhei, Ichikawa, Daisuke, Miyamae, Mahito, Kawaguchi, Tsutomu, Morimura, Ryo, Hirajima, Shoji, Okajima, Wataru, Ohashi, Takuma, Imamura, Taisuke, Konishi, Hirotaka, Shiozaki, Atsushi, Ikoma, Hisashi, Okamoto, Kazuma, Taniguchi, Hiroki, Otsuji, Eigo

“…Recent studies have identified that microRNAs are stably detectable in plasma/serum because of their binding to specific proteins or being packaged in…”
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