Search Results - "Kawaguchi, Tokuichi"

Platelet-derived lysophosphatidic acid mediated LPAR1 activation as a therapeutic target for osteosarcoma metastasis by Takagi, Satoshi, Sasaki, Yuki, Koike, Sumie, Takemoto, Ai, Seto, Yosuke, Haraguchi, Mizuki, Ukaji, Takao, Kawaguchi, Tokuichi, Sugawara, Minoru, Saito, Masanori, Funauchi, Yuki, Ae, Keisuke, Matsumoto, Seiichi, Fujita, Naoya, Katayama, Ryohei

“…Osteosarcoma is the most common primary malignant bone cancer, with high rates of pulmonary metastasis. Osteosarcoma patients with pulmonary metastasis have…”
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Targeting Podoplanin for the Treatment of Osteosarcoma by Takemoto, Ai, Takagi, Satoshi, Ukaji, Takao, Gyobu, Nobuhiko, Kakino, Mamoru, Takami, Miho, Kobayashi, Asami, Lebel, Marie, Kawaguchi, Tokuichi, Sugawara, Minoru, Tsuji-Takayama, Kazue, Ichihara, Kenji, Funauchi, Yuki, Ae, Keisuke, Matsumoto, Seiichi, Sugiura, Yoshiya, Takeuchi, Kengo, Noda, Tetsuo, Katayama, Ryohei, Fujita, Naoya

“…Osteosarcoma, the most common bone malignancy in children, has a poor prognosis, especially when the tumor metastasizes to the lungs. Therefore, novel…”
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Cancer-Specific Targeting of Taurine-Upregulated Gene 1 Enhances the Effects of Chemotherapy in Pancreatic Cancer by Tasaki, Yoshihiko, Suzuki, Miho, Katsushima, Keisuke, Shinjo, Keiko, Iijima, Kenta, Murofushi, Yoshiteru, Naiki-Ito, Aya, Hayashi, Kazuki, Qiu, Chenjie, Takahashi, Akiko, Tanaka, Yoko, Kawaguchi, Tokuichi, Sugawara, Minoru, Kataoka, Tomoya, Naito, Mitsuru, Miyata, Kanjiro, Kataoka, Kazunori, Noda, Tetsuo, Gao, Wentao, Kataoka, Hiromi, Takahashi, Satoru, Kimura, Kazunori, Kondo, Yutaka

“…Overcoming drug resistance is one of the biggest challenges in cancer chemotherapy. In this study, we examine whether targeting the long noncoding RNA taurine…”
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Fascin protein stabilization by miR-146a implicated in the process of a chronic inflammation-related colon carcinogenesis model by Kanda, Yusuke, Kawaguchi, Tokuichi, Osaki, Mitsuhiko, Onuma, Kunishige, Ochiya, Takahiro, Kitagawa, Tomoyuki, Okada, Futoshi

“…Objective In sporadic colon tumors, multistep process of well-known genetic alterations accelerates carcinogenesis; however, this does not appear to be the…”
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Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency by Wang, Linghua, Tsutsumi, Shuichi, Kawaguchi, Tokuichi, Nagasaki, Koichi, Tatsuno, Kenji, Yamamoto, Shogo, Sang, Fei, Sonoda, Kohtaro, Sugawara, Minoru, Saiura, Akio, Hirono, Seiko, Yamaue, Hiroki, Miki, Yoshio, Isomura, Minoru, Totoki, Yasushi, Nagae, Genta, Isagawa, Takayuki, Ueda, Hiroki, Murayama-Hosokawa, Satsuki, Shibata, Tatsuhiro, Sakamoto, Hiromi, Kanai, Yae, Kaneda, Atsushi, Noda, Tetsuo, Aburatani, Hiroyuki

“…Whole-exome sequencing (Exome-seq) has been successfully applied in several recent studies. We here sequenced the exomes of 15 pancreatic tumor cell lines and…”
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Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment by Yoshida, Junjiro, Ohishi, Tomokazu, Abe, Hikaru, Ohba, Shun-ichi, Inoue, Hiroyuki, Usami, Ihomi, Amemiya, Masahide, Oriez, Raphael, Sakashita, Chiharu, Dan, Shingo, Sugawara, Minoru, Kawaguchi, Tokuichi, Ueno, Junko, Asano, Yuko, Ikeda, Ami, Takamatsu, Manabu, Amori, Gulanbar, Kondoh, Yasumitsu, Honda, Kaori, Osada, Hiroyuki, Noda, Tetsuo, Watanabe, Takumi, Shimizu, Takao, Shibasaki, Masakatsu, Kawada, Manabu

“…The disruption of the tumor microenvironment (TME) is a promising anti-cancer strategy, but its effective targeting for solid tumors remains unknown. Here, we…”
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Epidermal growth factor‐dependent enhancement of invasiveness of squamous cell carcinoma of the breast by Kimura, Fuyo, Iwaya, Keiichi, Kawaguchi, Tokuichi, Kaise, Hiroshi, Yamada, Kimito, Mukai, Kiyoshi, Matsubara, Osamu, Ikeda, Norihiko, Kohno, Norio

“…Factors that promote the aggressiveness of squamous cell carcinoma of the breast are not well understood. To examine the involvement of cell motility and the…”
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Fascin regulates chronic inflammation-related human colon carcinogenesis by inhibiting cell anoikis by Kanda, Yusuke, Kawaguchi, Tokuichi, Kuramitsu, Yasuhiro, Kitagawa, Takao, Kobayashi, Tokushige, Takahashi, Norihiko, Tazawa, Hiroshi, Habelhah, Hasem, Hamada, Jun-ichi, Kobayashi, Masanobu, Hirahata, Mio, Onuma, Kunishige, Osaki, Mitsuhiko, Nakamura, Kazuyuki, Kitagawa, Tomoyuki, Hosokawa, Masuo, Okada, Futoshi

“…By a proteomics‐based approach, we identified an overexpression of fascin in colon adenocarcinoma cells (FPCKpP‐3) that developed from nontumorigenic human…”
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selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase by Kumada, Kazuki, Yao, Ryoji, Kawaguchi, Tokuichi, Karasawa, Mika, Hoshikawa, Yutaka, Ichikawa, Koji, Sugitani, Yoshinobu, Imoto, Issei, Inazawa, Johji, Sugawara, Minoru, Yanagida, Mitsuhiro, Noda, Tetsuo

“…Separase is an evolutionarily conserved protease that is essential for chromosome segregation and cleaves cohesin Scc1/Rad21, which joins the sister chromatids…”
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γ‐Glutamyltranspeptidase (GGT)‐Activatable Fluorescence Probe for Durable Tumor Imaging by Obara, Rui, Kamiya, Mako, Tanaka, Yoko, Abe, Atsuki, Kojima, Ryosuke, Kawaguchi, Tokuichi, Sugawara, Minoru, Takahashi, Akiko, Noda, Tetsuo, Urano, Yasuteru

“…γ‐Glutamyltranspeptidase (GGT) is overexpressed in several types of cancer. Existing GGT‐targeting fluorescence probes can image these cancers, but the…”
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Identification of candidate predictive markers of anticancer drug sensitivity using a panel of human cancer cell lines by Dan, Shingo, Shirakawa, Mieko, Mukai, Yumiko, Yoshida, Yoko, Yamazaki, Kanami, Kawaguchi, Tokuichi, Matsuura, Masaaki, Nakamura, Yusuke, Yamori, Takao

“…We previously investigated the correlations between the expression of 9216 genes and various chemosensitivities in a panel of 39 human cancer cell lines1) and…”
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Conversion of Human Colonic Adenoma Cells to Adenocarcinoma Cells Through Inflammation in Nude Mice by Okada, Futoshi, Kawaguchi, Tokuichi, Habelhah, Hasem, Kobayashi, Tokushige, Tazawa, Hiroshi, Takeichi, Noritoshi, Kitagawa, Tomoyuki, Hosokawa, Masuo

“…The roles of inflammation in the malignant progression of tumors during multistep carcinogenesis have been much discussed but remain to be elucidated. To…”
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Ectopic chromosome around centrosome in metaphase cells as a marker of high‐risk human papillomavirus–associated cervical intraepithelial neoplasias by Furuta, Reiko, Hirai, Yasuo, Katase, Katsuyoshi, Tate, Shinichi, Kawaguchi, Tokuichi, Akiyama, Futoshi, Kato, Yo, Kumada, Kazuki, Iwasaka, Tsuyoshi, Yaegashi, Nobuo, Kanazawa, Koji, Yoshikawa, Hiroyuki, Kitagawa, Tomoyuki

“…This report describes the appearance of ectopic chromosome around centrosome (ECAC) in metaphase cell nuclei of high‐risk HPV‐associated cervical neoplasms…”
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Abstract 1954: Functional analyses of CLDN18-ARHGAP26 fusion gene in gastric cancers by Nakayama, Izuma, Shinozaki, Eiji, Mashima, Tetsuo, Kawaguchi, Tokuichi, Sakata, Seiji, Yamamoto, Noriko, Baba, Satoko, Dobashi, Akito, Togashi, Yuki, Sugawara, Minoru, Takahashi, Shunji, Yamaguchi, Kensei, Takeuchi, Kengo, Noda, Tetsuo

“…[Introduction]Comprehensive molecular analyses by TCGA have classified Gastric Cancers (GC) into 4 groups: EB virus -associated (EBV), Microsatellite…”
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Abstract 1543: Systematic functional assessment of driver mutations for individual ovarian cancers by Mori, Seiichi, Yokomizo, Takako, Fujiwara, Takeshi, Goto, Osamu, Iwase, Haruko, Kato, Kazuyoshi, Kawaguchi, Tokuichi, Noda, Tetsuo

“…Although epithelial ovarian cancer is an intractable cancer and the overall five-year survival rate is approximately 40 to 50%, clinically effective…”
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Autonomous cure of damaged human intestinal epithelial cells by TLR2 and TLR4-dependent production of IL-22 in response to Spirulina polysaccharides by Tominaga, Akira, Konishi, Yuko, Taguchi, Takahiro, Fukuoka, Satoshi, Kawaguchi, Tokuichi, Noda, Tetsuo, Shimizu, Keiji

“…In order to analyze the damage of human epithelial cells, we used human quasi-normal FPCK-1-1 cells derived from a colonic polyp in a patient with familial…”
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γ‐Glutamyltranspeptidase (GGT)‐Activatable Fluorescence Probe for Durable Tumor Imaging by Obara, Rui, Kamiya, Mako, Tanaka, Yoko, Abe, Atsuki, Kojima, Ryosuke, Kawaguchi, Tokuichi, Sugawara, Minoru, Takahashi, Akiko, Noda, Tetsuo, Urano, Yasuteru

“…γ‐Glutamyltranspeptidase (GGT) is overexpressed in several types of cancer. Existing GGT‐targeting fluorescence probes can image these cancers, but the…”
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Chronic inflammation-derived nitric oxide causes conversion of human colonic adenoma cells into adenocarcinoma cells by Tazawa, Hiroshi, Kawaguchi, Tokuichi, Kobayashi, Tokushige, Kuramitsu, Yasuhiro, Wada, Sayori, Satomi, Yoshiko, Nishino, Hoyoku, Kobayashi, Masanobu, Kanda, Yusuke, Osaki, Mitsuhiko, Kitagawa, Tomoyuki, Hosokawa, Masuo, Okada, Futoshi

“…It has been suggested that nitric oxide (NO) derived from chronically inflamed tissues is a cause of carcinogenesis. We herein demonstrated that administration…”
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Abstract 2996: Systematic functional identification of driver mutations for individual ovarian cancers by Mori, Seiichi, Fujiwara, Takeshi, Yokomizo, Takako, Iwase, Haruko, Kato, Kazuyoshi, Nakashima, Yukie, Kawaguchi, Tokuichi, Noda, Tetsuo

“…Although epithelial ovarian cancer is an intractable cancer and the overall five-year survival rate is approximately 40 to 50%, clinically effective…”
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Establishment and characterization of human cell lines from a serous papillary adenocarcinoma of the endometrium by Hirai, Y, Kawaguchi, T, Hasumi, K, Kitagawa, T, Noda, T

“…Two cell lines, SPAC-1-L and SPAC-1-S, derived from a human serous papillary endometrial adenocarcinoma, have been established and repetitively subcultured as…”
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