Search Results - "Kawaguchi, Riki"

Transcriptional Reprogramming of Distinct Peripheral Sensory Neuron Subtypes after Axonal Injury by Renthal, William, Tochitsky, Ivan, Yang, Lite, Cheng, Yung-Chih, Li, Emmy, Kawaguchi, Riki, Geschwind, Daniel H., Woolf, Clifford J.

“…Primary somatosensory neurons are specialized to transmit specific types of sensory information through differences in cell size, myelination, and the…”
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Molecular basis of astrocyte diversity and morphology across the CNS in health and disease by Endo, Fumito, Kasai, Atsushi, Soto, Joselyn S, Yu, Xinzhu, Qu, Zhe, Hashimoto, Hitoshi, Gradinaru, Viviana, Kawaguchi, Riki, Khakh, Baljit S

“…Astrocytes, a type of glia, are abundant and morphologically complex cells. Here, we report astrocyte molecular profiles, diversity, and morphology across the…”
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Microglia-organized scar-free spinal cord repair in neonatal mice by Li, Yi, He, Xuelian, Kawaguchi, Riki, Zhang, Yu, Wang, Qing, Monavarfeshani, Aboozar, Yang, Zhiyun, Chen, Bo, Shi, Zhongju, Meng, Huyan, Zhou, Songlin, Zhu, Junjie, Jacobi, Anne, Swarup, Vivek, Popovich, Phillip G., Geschwind, Daniel H., He, Zhigang

“…Spinal cord injury in mammals is thought to trigger scar formation with little regeneration of axons 1 – 4 . Here we show that a crush injury to the spinal…”
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Astrocyte scar formation aids central nervous system axon regeneration by Anderson, Mark A., Burda, Joshua E., Ren, Yilong, Ao, Yan, O’Shea, Timothy M., Kawaguchi, Riki, Coppola, Giovanni, Khakh, Baljit S., Deming, Timothy J., Sofroniew, Michael V.

“…Transected axons fail to regrow in the mature central nervous system. Astrocytic scars are widely regarded as causal in this failure. Here, using three…”
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Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map by Bayraktar, Omer Ali, Bartels, Theresa, Holmqvist, Staffan, Kleshchevnikov, Vitalii, Martirosyan, Araks, Polioudakis, Damon, Ben Haim, Lucile, Young, Adam M. H., Batiuk, Mykhailo Y., Prakash, Kirti, Brown, Alexander, Roberts, Kenny, Paredes, Mercedes F., Kawaguchi, Riki, Stockley, John H., Sabeur, Khalida, Chang, Sandra M., Huang, Eric, Hutchinson, Peter, Ullian, Erik M., Hemberg, Martin, Coppola, Giovanni, Holt, Matthew G., Geschwind, Daniel H., Rowitch, David H.

“…Although the cerebral cortex is organized into six excitatory neuronal layers, it is unclear whether glial cells show distinct layering. In the present study,…”
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Required growth facilitators propel axon regeneration across complete spinal cord injury by Anderson, Mark A., O’Shea, Timothy M., Burda, Joshua E., Ao, Yan, Barlatey, Sabry L., Bernstein, Alexander M., Kim, Jae H., James, Nicholas D., Rogers, Alexandra, Kato, Brian, Wollenberg, Alexander L., Kawaguchi, Riki, Coppola, Giovanni, Wang, Chen, Deming, Timothy J., He, Zhigang, Courtine, Gregoire, Sofroniew, Michael V.

“…Transected axons fail to regrow across anatomically complete spinal cord injuries (SCI) in adults. Diverse molecules can partially facilitate or attenuate axon…”
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Sox11 Expression Promotes Regeneration of Some Retinal Ganglion Cell Types but Kills Others by Norsworthy, Michael W., Bei, Fengfeng, Kawaguchi, Riki, Wang, Qing, Tran, Nicholas M., Li, Yi, Brommer, Benedikt, Zhang, Yiming, Wang, Chen, Sanes, Joshua R., Coppola, Giovanni, He, Zhigang

“…At least 30 types of retinal ganglion cells (RGCs) send distinct messages through the optic nerve to the brain. Available strategies of promoting axon…”
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Divergent transcriptional regulation of astrocyte reactivity across disorders by Burda, Joshua E., O’Shea, Timothy M., Ao, Yan, Suresh, Keshav B., Wang, Shinong, Bernstein, Alexander M., Chandra, Ashu, Deverasetty, Sandeep, Kawaguchi, Riki, Kim, Jae H., McCallum, Sarah, Rogers, Alexandra, Wahane, Shalaka, Sofroniew, Michael V.

“…Astrocytes respond to injury and disease in the central nervous system with reactive changes that influence the outcome of the disorder 1 – 4 . These changes…”
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Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer’s disease by Otero-Garcia, Marcos, Mahajani, Sameehan U., Wakhloo, Debia, Tang, Weijing, Xue, Yue-Qiang, Morabito, Samuel, Pan, Jie, Oberhauser, Jane, Madira, Angela E., Shakouri, Tamara, Deng, Yongning, Allison, Thomas, He, Zihuai, Lowry, William E., Kawaguchi, Riki, Swarup, Vivek, Cobos, Inma

“…Tau aggregation in neurofibrillary tangles (NFTs) is closely associated with neurodegeneration and cognitive decline in Alzheimer’s disease (AD). However, the…”
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Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD by Gandal, Michael J., Haney, Jillian R., Wamsley, Brie, Yap, Chloe X., Parhami, Sepideh, Emani, Prashant S., Chang, Nathan, Chen, George T., Hoftman, Gil D., de Alba, Diego, Ramaswami, Gokul, Hartl, Christopher L., Bhattacharya, Arjun, Luo, Chongyuan, Jin, Ting, Wang, Daifeng, Kawaguchi, Riki, Quintero, Diana, Ou, Jing, Wu, Ye Emily, Parikshak, Neelroop N., Swarup, Vivek, Belgard, T. Grant, Gerstein, Mark, Pasaniuc, Bogdan, Geschwind, Daniel H.

“…Neuropsychiatric disorders classically lack defining brain pathologies, but recent work has demonstrated dysregulation at the molecular level, characterized by…”
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The effect of Rbfox2 modulation on retinal transcriptome and visual function by Gu, Lei, Kawaguchi, Riki, Caprioli, Joseph, Piri, Natik

“…Rbfox proteins regulate alternative splicing, mRNA stability and translation. These proteins are involved in neurogenesis and have been associated with various…”
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Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement by Kalinski, Ashley L, Yoon, Choya, Huffman, Lucas D, Duncker, Patrick C, Kohen, Rafi, Passino, Ryan, Hafner, Hannah, Johnson, Craig, Kawaguchi, Riki, Carbajal, Kevin S, Jara, Juan Sebastian, Hollis, Edmund, Geschwind, Daniel H, Segal, Benjamin M, Giger, Roman J

“…Sciatic nerve crush injury triggers sterile inflammation within the distal nerve and axotomized dorsal root ganglia (DRGs). Granulocytes and pro-inflammatory…”
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Membrane Receptor for Retinol Binding Protein Mediates Cellular Uptake of Vitamin A by Kawaguchi, Riki, Yu, Jiamei, Honda, Jane, Hu, Jane, Whitelegge, Julian, Ping, Peipei, Wiita, Patrick, Bok, Dean, Sun, Hui

“…Vitamin A has diverse biological functions. It is transported in the blood as a complex with retinol binding protein (RBP), but the molecular mechanism by…”
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A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequences by Gleichman, Amy J., Kawaguchi, Riki, Sofroniew, Michael V., Carmichael, S. Thomas

“…Astrocytes, one of the most prevalent cell types in the central nervous system (CNS), are critically involved in neural function. Genetically manipulating…”
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Robust Hi-C Maps of Enhancer-Promoter Interactions Reveal the Function of Non-coding Genome in Neural Development and Diseases by Lu, Leina, Liu, Xiaoxiao, Huang, Wei-Kai, Giusti-Rodríguez, Paola, Cui, Jian, Zhang, Shanshan, Xu, Wanying, Wen, Zhexing, Ma, Shufeng, Rosen, Jonathan D., Xu, Zheng, Bartels, Cynthia F., Kawaguchi, Riki, Hu, Ming, Scacheri, Peter C., Rong, Zhili, Li, Yun, Sullivan, Patrick F., Song, Hongjun, Ming, Guo-li, Li, Yan, Jin, Fulai

“…Genome-wide mapping of chromatin interactions at high resolution remains experimentally and computationally challenging. Here we used a low-input “easy Hi-C”…”
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DYNLRB1 is essential for dynein mediated transport and neuronal survival by Terenzio, Marco, Di Pizio, Agostina, Rishal, Ida, Marvaldi, Letizia, Di Matteo, Pierluigi, Kawaguchi, Riki, Coppola, Giovanni, Schiavo, Giampietro, Fisher, Elizabeth M.C., Fainzilber, Mike

“…The cytoplasmic dynein motor complex transports essential signals and organelles from the cell periphery to the perinuclear region, hence is critical for the…”
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GDF10 is a signal for axonal sprouting and functional recovery after stroke by Li, Songlin, Nie, Esther H, Yin, Yuqin, Benowitz, Larry I, Tung, Spencer, Vinters, Harry V, Bahjat, F Rena, Stenzel-Poore, Mary P, Kawaguchi, Riki, Coppola, Giovanni, Carmichael, S Thomas

“…Stroke is the leading cause of adult disability. This study shows that the secreted factor GDF10 is a signal for the formation of new brain connections that…”
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The injured sciatic nerve atlas (iSNAT), insights into the cellular and molecular basis of neural tissue degeneration and regeneration by Zhao, Xiao-Feng, Huffman, Lucas D, Hafner, Hannah, Athaiya, Mitre, Finneran, Matthew C, Kalinski, Ashley L, Kohen, Rafi, Flynn, Corey, Passino, Ryan, Johnson, Craig N, Kohrman, David, Kawaguchi, Riki, Yang, Lynda J S, Twiss, Jeffery L, Geschwind, Daniel H, Corfas, Gabriel, Giger, Roman J

“…Upon trauma, the adult murine peripheral nervous system (PNS) displays a remarkable degree of spontaneous anatomical and functional regeneration. To explore…”
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The Membrane Receptor for Plasma Retinol-Binding Protein, A New Type of Cell-Surface Receptor by Sun, Hui, Kawaguchi, Riki

“…Vitamin A is essential for diverse aspects of life ranging from embryogenesis to the proper functioning of most adult organs. Its derivatives (retinoids) have…”
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Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration in mice by Cheng, Yuyan, Yin, Yuqin, Zhang, Alice, Bernstein, Alexander M., Kawaguchi, Riki, Gao, Kun, Potter, Kyra, Gilbert, Hui-Ya, Ao, Yan, Ou, Jing, Fricano-Kugler, Catherine J., Goldberg, Jeffrey L., He, Zhigang, Woolf, Clifford J., Sofroniew, Michael V., Benowitz, Larry I., Geschwind, Daniel H.

“…The inability of neurons to regenerate long axons within the CNS is a major impediment to improving outcome after spinal cord injury, stroke, and other CNS…”
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