Search Results - "Kawachi, Tomoyuki"

Generation of intestinal organoids derived from human pluripotent stem cells for drug testing by Yoshida, Shinpei, Miwa, Hiroto, Kawachi, Tomoyuki, Kume, Shoen, Takahashi, Koji

“…Drug absorption via the intestinal tissue is modulated by membrane permeability and metabolism in intestinal epithelial cells (IECs). In drug discovery…”
Get full text

A new trapping method to quantitatively assess the formation of reactive metabolites from drugs which cause agranulocytosis by Kawachi, Tomoyuki, Nakajima, Miki, Fukami, Tatsuki

Get full text

Isolation and Characterization of an Anti-Insect β-Toxin from the Venom of the Scorpion Isometrus maculatus by KAWACHI, Tomoyuki, MIYASHITA, Masahiro, NAKAGAWA, Yoshiaki, MIYAGAWA, Hisashi

“…Im-3 was isolated from the venom of the scorpion Isometrus maculatus through several steps of HPLC fractionation based on the insect paralytic activity…”
Get full text

Isolation and Characterization of a Novel Non-Selective β-Toxin from the Venom of the Scorpion Isometrus maculatus by ICHIKI, Yayoi, KAWACHI, Tomoyuki, MIYASHITA, Masahiro, NAKAGAWA, Yoshiaki, MIYAGAWA, Hisashi

“…Scorpion venom is composed of a number of peptides, many of which show neurotoxicity. The Isometrus maculatus scorpion, belonging to the Buthidae family, is…”
Get full text

Solution structure of a short-chain insecticidal toxin LaIT1 from the venom of scorpion Liocheles australasiae by Horita, Shoichiro, Matsushita, Nobuto, Kawachi, Tomoyuki, Ayabe, Reed, Miyashita, Masahiro, Miyakawa, Takuya, Nakagawa, Yoshiaki, Nagata, Koji, Miyagawa, Hisashi, Tanokura, Masaru

“…► Solution structure of a scorpion insecticidal toxin LaIT1 is determined. ► LaIT1 exhibits a new class of inhibitory cystine knot (ICK)-like fold. ► LaIT1 has…”
Get full text

Human mass balance, metabolism, and cytochrome P450 phenotyping of lusutrombopag by Kawachi, Tomoyuki, Ninomiya, Mizuki, Katsube, Takayuki, Wajima, Toshihiro, Kanazu, Takushi

“…The human mass balance of lusutrombopag, an orally bioavailable thrombopoietin (TPO) receptor agonist, was characterised in seven healthy male subjects after a…”
Get full text

Discovery of 2‑Sulfinyl-Diazabicyclooctane Derivatives, Potential Oral β‑Lactamase Inhibitors for Infections Caused by Serine β‑Lactamase-Producing Enterobacterales by Fujiu, Motohiro, Yokoo, Katsuki, Sato, Jun, Shibuya, Satoru, Komano, Kazuo, Kusano, Hiroki, Sato, Soichiro, Aoki, Toshiaki, Kohira, Naoki, Kanazawa, Sachi, Watari, Ryosuke, Kawachi, Tomoyuki, Hirakawa, Yuya, Nagamatsu, Daiki, Kashiwagi, Emi, Maki, Hideki, Yamawaki, Kenji

“…Coadministration of β-lactam and β-lactamase inhibitor (BLI) is one of the well-established therapeutic measures for bacterial infections caused by…”
Get full text

Trifluoromethyl Dihydrothiazine‐Based β‐Secretase (BACE1) Inhibitors with Robust Central β‐Amyloid Reduction and Minimal Covalent Binding Burden by Anan, Kosuke, Iso, Yasuyoshi, Oguma, Takuya, Nakahara, Kenji, Suzuki, Shinji, Yamamoto, Takahiko, Matsuoka, Eriko, Ito, Hisanori, Sakaguchi, Gaku, Ando, Shigeru, Morimoto, Kenji, Kanegawa, Naoki, Kido, Yasuto, Kawachi, Tomoyuki, Fukushima, Tamio, Teisman, Ard, Urmaliya, Vijay, Dhuyvetter, Deborah, Borghys, Herman, Austin, Nigel, Van Den Bergh, An, Verboven, Peter, Bischoff, Francois, Gijsen, Harrie J. M., Yamano, Yoshinori, Kusakabe, Kenichi

“…The β‐site amyloid precursor protein cleaving enzyme 1 (BACE1, also known as β‐secretase) is a promising target for the treatment of Alzheimer's disease. A pKa…”
Get full text

Introduction of a Thio Functional Group to Diazabicyclooctane: An Effective Modification to Potentiate the Activity of β‑Lactams against Gram-Negative Bacteria Producing Class A, C, and D Serine β‑Lactamases by Fujiu, Motohiro, Yokoo, Katsuki, Sato, Jun, Shibuya, Satoru, Komano, Kazuo, Kusano, Hiroki, Sato, Soichiro, Aoki, Toshiaki, Kohira, Naoki, Miyagawa, Satoshi, Kawachi, Tomoyuki, Yamawaki, Kenji

“…By the emergence and worldwide spread of multi-drug-resistant Gram-negative bacteria, there have been growing demands for efficacious drugs to cure these…”
Get full text

Isolation and Characterization of an Anti-Insect [beta]-Toxin from the Venom of the Scorpion Isometrus maculatus by KAWACHI, Tomoyuki, MIYASHITA, Masahiro, NAKAGAWA, Yoshiaki, MIYAGAWA, Hisashi

“…Im-3 was isolated from the venom of the scorpion Isometrus maculatus through several steps of HPLC fractionation based on the insect paralytic activity…”
Get full text

Isolation and Characterization of a Novel Non-Selective [beta]-Toxin from the Venom of the Scorpion Isometrus maculatus by ICHIKI, Yayoi, KAWACHI, Tomoyuki, MIYASHITA, Masahiro, NAKAGAWA, Yoshiaki, MIYAGAWA, Hisashi

“…Scorpion venom is composed of a number of peptides, many of which show neurotoxicity. The Isometrus maculatus scorpion, belonging to the Buthidae family, is…”
Get full text