Search Results - "Kawabata, Mitsuhiko"

Development of a bioanalytical method for an antisense therapeutic using high-resolution mass spectrometry by Sun, Yuchen, Nitta, Shin-ichiro, Saito, Kosuke, Hosogai, Ryuta, Nakai, Keiko, Goda, Ryoya, Kakehi, Masaaki, Murata, Kazuyuki, Yamaguchi, Takeru, Okuzono, Takeshi, Yamane, Shinichi, Enoki, Yoshimasa, Kawabata, Mitsuhiko, Takahara, Kentaro, Sato, Shimpei, Yoshida, Tokuyuki, Inoue, Takao, Saito, Yoshiro

“…Ion-pairing reverse-phase LC coupled with high-resolution mass spectrometry (IP-LC/HRMS) has gained attention in oligonucleotide therapeutic bioanalyses owing…”
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A multilaboratory validation study of LC/MS biomarker assays for three lysophosphatidylcholines by Ishikawa, Rika, Saito, Kosuke, Matsumura, Tsuyoshi, Arai, Koji, Yamauchi, Saki, Goda, Ryoya, Tachiki, Hidehisa, Kawabata, Mitsuhiko, Nitta, Shin-Ichiro, Nagao, Akemi, Suga, Takahiro, Uchiyama, Hitoshi, Nakai, Keiko, Asahina, Kota, Yamaoka, Mariko, Saito, Yoshiro

“…Although the fit-for-purpose approach has been proposed for validation procedures and acceptance criteria for biomarker assays, practical biomarker assays to…”
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Development and multicenter validation of an LC–MS-based bioanalytical method for antisense therapeutics by Sun, Yuchen, Nitta, Shin-ichiro, Saito, Kosuke, Hosogai, Ryuta, Nakai, Keiko, Goda, Ryoya, Shimizu, Hisao, Fujita, Hisashi, Kakehi, Masaaki, Murata, Kazuyuki, Yamaguchi, Takeru, Okuzono, Takeshi, Yamane, Shinichi, Kawabata, Mitsuhiko, Matsunuma, Takayuki, Takahara, Kentaro, Kato, Noriko, Yamada, Masaki, Yoshida, Tokuyuki, Inoue, Takao, Saito, Yoshiro

“…Many bioanalytical methods for antisense oligonucleotides (ASOs) using LC–MS have been reported. However, no data have been available on the reproducibility…”
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Pharmacokinetics and metabolism of brexpiprazole, a novel serotonin-dopamine activity modulator and its main metabolite in rat, monkey and human by Sasabe, Hiroyuki, Koga, Toshihisa, Furukawa, Masayuki, Matsunaga, Masayuki, Kaneko, Yosuke, Koyama, Noriyuki, Hirao, Yukihiro, Akazawa, Hitomi, Kawabata, Mitsuhiko, Kashiyama, Eiji, Takeuchi, Kenji

“…The pharmacokinetics of brexpiprazole were investigated in the and .The total body clearance of brexpiprazole in rat and monkey was 2.32 and 0.326 L/h/kg,…”
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Function of the Propeptide Region in Recombinant Expression of Active Procathepsin L in Escherichia coli by Ogino, Tetsuya, Kaji, Toshio, Kawabata, Mitsuhiko, Satoh, Kazumasa, Tomoo, Koji, Ishida, Toshimasa, Yamazaki, Hiroshi, Ishidoh, Kazumi, Kominami, Eiki

“…In order to determine the functional role of the procathepsin L propeptide region for the preparation of active recombinant rat cathepsin L (CL), cDNAs…”
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Interlaboratory evaluation of LC-MS-based biomarker assays by Saito, Kosuke, Goda, Ryoya, Arai, Koji, Asahina, Kota, Kawabata, Mitsuhiko, Uchiyama, Hitoshi, Andou, Tomohiro, Shimizu, Hisao, Takahara, Kentaro, Kakehi, Masaaki, Yamauchi, Saki, Nitta, Shin-Ichiro, Suga, Takahiro, Fujita, Hisashi, Ishikawa, Rika, Saito, Yoshiro

“…Validation of biomarker assays is crucial for effective drug development and clinical applications. Interlaboratory reproducibility is vital for reliable…”
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Bioanalysis of therapeutic monoclonal antibody by peptide adsorption-controlled LC–MS by Hashii, Noritaka, Tousaka, Yoshiko, Arai, Koji, Enoki, Yoshimasa, Fukuda, Suguru, Goda, Ryoya, Inoue, Noriko, Kawabata, Mitsuhiko, Murata, Kazuyuki, Nakatsuji, Mio, Okuzono, Takeshi, Shigeyama, Takuma, Tachiki, Hidehisa, Yamaguchi, Takeru, Yamane, Shinichi, Yamaoka, Mariko, Saito, Yoshiro, Ishii-Watabe, Akiko

“…We aimed to develop an easy, low-cost and versatile mass spectrometric method for the bioanalysis of a therapeutic monoclonal antibody (mAb) in human serum…”
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Gender-related difference in the toxicity of 2-(2′-hydroxy-3′,5′-di-tert-butylphenyl)benzotriazole in rats: Relationship to the plasma concentration, in vitro hepatic metabolism, and effects on hepatic metabolizing enzyme activity by Hirata-Koizumi, Mutsuko, Matsuno, Kiyomi, Kawabata, Mitsuhiko, Yajima, Kanako, Matsuyama, Takashi, Hirose, Akihiko, Kamata, Eiichi, Ema, Makoto

“…Previously, we showed that the toxic susceptibility of male rats to an ultraviolet absorber, 2-(2′-hydroxy- 3′,5′-di-tert-butylphenyl)benzotriazole (HDBB), was…”
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