Search Results - "Kawabata, Kenji"

Transient ETV2 Expression Promotes the Generation of Mature Endothelial Cells from Human Pluripotent Stem Cells by Zhang, Hongyan, Yamaguchi, Tomoko, Kokubu, Yasuhiro, Kawabata, Kenji

“…Differentiation protocols are used for induced pluripotent stem cells (iPSCs) in in vitro disease modeling and clinical applications. Transplantation of…”
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Inhibition of Glycogen Synthase Kinase 3ß Enhances Functions of Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells in the Blood–Brain Barrier by Yamaguchi, Tomoko, Nishijima, Misae, Kawabata, Kenji

“…Brain microvascular endothelial cells (BMECs) are essential component of the blood–brain barrier (BBB). BMECs strictly regulate the entry of various molecules…”
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In vitro model of cerebral ischemia by using brain microvascular endothelial cells derived from human induced pluripotent stem cells by Kokubu, Yasuhiro, Yamaguchi, Tomoko, Kawabata, Kenji

“…Brain-derived microvascular endothelial cells (BMECs), which play a central role in blood brain barrier (BBB), can be used for the evaluation of drug transport…”
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The maturation of iPS cell-derived brain microvascular endothelial cells by inducible-SOX18 expression by Zhang, Hongyan, Yamaguchi, Tomoko, Kawabata, Kenji

“…Brain microvascular endothelial cells (BMECs) play a major role in the blood-brain barrier (BBB), and are critical for establishing an in vitro BBB model…”
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Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes by Takayama, Kazuo, Morisaki, Yuta, Kuno, Shuichi, Nagamoto, Yasuhito, Harada, Kazuo, Furukawa, Norihisa, Ohtaka, Manami, Nishimura, Ken, Imagawa, Kazuo, Sakurai, Fuminori, Tachibana, Masashi, Sumazaki, Ryo, Noguchi, Emiko, Nakanishi, Mahito, Hirata, Kazumasa, Kawabata, Kenji, Mizuguchi, Hiroyuki

“…Interindividual differences in hepatic metabolism, which are mainly due to genetic polymorphism in its gene, have a large influence on individual drug efficacy…”
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Human Induced Pluripotent Stem Cell-Based Skin for Assessing Transdermal Drug Permeability and Irritancy by Naito, Chihiro, Yamaguchi, Tomoko, Katsumi, Hidemasa, Kimura, Suyo, Kamei, Sachi, Morishita, Masaki, Kawabata, Kenji, Yamamoto, Akira

“…To establish a system for assessing drug permeation and irritation of the skin, the permeation of benzoic acid and isosorbide dinitrate, which are listed in…”
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Effect of heat stress on blood-brain barrier integrity in iPS cell-derived microvascular endothelial cell models by Yamaguchi, Tomoko, Shimizu, Kentaro, Kokubu, Yasuhiro, Nishijima, Misae, Takeda, Shuko, Ogura, Hiroshi, Kawabata, Kenji

“…The incidence of heatstroke has been increasing. Heatstroke has been shown to affect physiological barrier functions. However, there are few studies of the…”
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The role of galanin in the differentiation of mucosal mast cells in mice by Yamaguchi, Tomoko, Ikeda, Yumi, Tashiro, Katsuhisa, Ohkawa, Yasuyuki, Kawabata, Kenji

“…Mast cells are generally classified into two phenotypically distinct populations: mucosal‐type mast cells (MMCs) and connective tissue‐type mast cells (CTMCs)…”
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Expression and Functional Characterization of Drug Transporters in Brain Microvascular Endothelial Cells Derived from Human Induced Pluripotent Stem Cells by Kurosawa, Toshiki, Tega, Yuma, Higuchi, Kei, Yamaguchi, Tomoko, Nakakura, Takashi, Mochizuki, Tatsuki, Kusuhara, Hiroyuki, Kawabata, Kenji, Deguchi, Yoshiharu

“…Brain microvascular endothelial cells derived from human induced pluripotent stem cells (hiPS-BMECs) have been proposed as a new blood–brain barrier model, but…”
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Functional Investigation of Solute Carrier Family 35, Member F2, in Three Cellular Models of the Primate Blood-Brain Barrier by Mochizuki, Tatsuki, Mizuno, Tadahaya, Kurosawa, Toshiki, Yamaguchi, Tomoko, Higuchi, Kei, Tega, Yuma, Nozaki, Yoshitane, Kawabata, Kenji, Deguchi, Yoshiharu, Kusuhara, Hiroyuki

“…Understanding the mechanisms of drug transport across the blood-brain barrier (BBB) is an important issue for regulating the pharmacokinetics of drugs in the…”
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Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine by Ozawa, Tatsuya, Takayama, Kazuo, Okamoto, Ryota, Negoro, Ryosuke, Sakurai, Fuminori, Tachibana, Masashi, Kawabata, Kenji, Mizuguchi, Hiroyuki

“…Enterocytes play an important role in drug absorption and metabolism. However, a widely used enterocyte model, Caco-2 cell, has difficulty in evaluating both…”
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Generation of Brain Microvascular Endothelial-Like Cells from Human Induced Pluripotent Stem Cells by Co-Culture with C6 Glioma Cells by Minami, Haruka, Tashiro, Katsuhisa, Okada, Atsumasa, Hirata, Nobue, Yamaguchi, Tomoko, Takayama, Kazuo, Mizuguchi, Hiroyuki, Kawabata, Kenji

“…The blood brain barrier (BBB) is formed by brain microvascular endothelial cells (BMECs) and tightly regulates the transport of molecules from blood to neural…”
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The promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets by Nagamoto, Yasuhito, Tashiro, Katsuhisa, Takayama, Kazuo, Ohashi, Kazuo, Kawabata, Kenji, Sakurai, Fuminori, Tachibana, Masashi, Hayakawa, Takao, Furue, Miho Kusuda, Mizuguchi, Hiroyuki

“…Abstract Hepatocyte-like cells differentiated from human embryonic stem cells (hESCs) or human induced pluripotent stem cells (hiPSCs) are known to be a useful…”
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Trisomy 12 compromises the mesendodermal differentiation propensity of human pluripotent stem cells by Yanagihara, Kana, Hayashi, Yohei, Liu, Yujung, Yamaguchi, Tomoko, Hemmi, Yasuko, Kokunugi, Minako, Yamada, Kozue Uchio, Fukumoto, Ken, Suga, Mika, Terada, Satoshi, Nikawa, Hiroki, Kawabata, Kenji, Furue, Miho

“…Trisomy 12 is one of the most frequent chromosomal abnormalities in cultured human pluripotent stem cells (hPSCs). Although potential oncogenic properties and…”
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Efficient Adipocyte and Osteoblast Differentiation from Mouse Induced Pluripotent Stem Cells by Adenoviral Transduction by Tashiro, Katsuhisa, Inamura, Mitsuru, Kawabata, Kenji, Sakurai, Fuminori, Yamanishi, Koichi, Hayakawa, Takao, Mizuguchi, Hiroyuki

“…Induced pluripotent stem (iPS) cells, which are generated from somatic cells by transducing four genes, are expected to have broad application to regenerative…”
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Ablation of IL-17A leads to severe colitis in IL-10-deficient mice: implications of myeloid-derived suppressor cells and NO production by Tachibana, Masashi, Watanabe, Nobumasa, Koda, Yuzo, Oya, Yukako, Kaminuma, Osamu, Katayama, Kazufumi, Fan, Zifei, Sakurai, Fuminori, Kawabata, Kenji, Hiroi, Takachika, Mizuguchi, Hiroyuki

“…Abstract IL-10 is an immune regulatory cytokine and its genetic defect leads to gastrointestinal inflammation in humans and mice. Moreover, the IL-23/Th17 axis…”
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Mixed adenoneuroendocrine carcinoma of the gallbladder with squamous cell carcinomatous and osteosarcomatous differentiation: Report of a case by Shintaku, Masayuki, Kataoka, Kozo, Kawabata, Kenji

“…An extremely rare case of mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder is reported, in which the tumor showed diverse differentiation toward…”
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Efficient Generation of Hepatoblasts From Human ES Cells and iPS Cells by Transient Overexpression of Homeobox Gene HEX by Inamura, Mitsuru, Kawabata, Kenji, Takayama, Kazuo, Tashiro, Katsuhisa, Sakurai, Fuminori, Katayama, Kazufumi, Toyoda, Masashi, Akutsu, Hidenori, Miyagawa, Yoshitaka, Okita, Hajime, Kiyokawa, Nobutaka, Umezawa, Akihiro, Hayakawa, Takao, Furue, Miho K, Mizuguchi, Hiroyuki

“…Human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have the potential to differentiate into all cell lineages, including hepatocytes,…”
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Long-Term Hematopoietic Stem Cells Require Stromal Cell-Derived Factor-1 for Colonizing Bone Marrow during Ontogeny by Ara, Toshiaki, Tokoyoda, Koji, Sugiyama, Tatsuki, Egawa, Takeshi, Kawabata, Kenji, Nagasawa, Takashi

“…The physiological role of SDF-1 on hematopoietic stem cells (HSCs) remains elusive. We show that colonization of bone marrow by HSCs in addition to myeloid…”
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Monitoring of glutamate‐induced excitotoxicity by mitochondrial oxygen consumption by Kumagai, Ayako, Sasaki, Tsutomu, Matsuoka, Kenta, Abe, Masayoshi, Tabata, Toshihide, Itoh, Yumi, Fuchino, Hiroyuki, Wugangerile, Sartagul, Suga, Mika, Yamaguchi, Tomoko, Kawahara, Hidehisa, Nagaoka, Yasuo, Kawabata, Kenji, Furue, Miho Kusuda, Takemori, Hiroshi

“…Dysfunction of mitochondrial activity is often associated with the onset and progress of neurodegenerative diseases. Membrane depolarization induced by Na+…”
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