Search Results - "Kavvas, Erol S"

A biochemically-interpretable machine learning classifier for microbial GWAS by Kavvas, Erol S., Yang, Laurence, Monk, Jonathan M., Heckmann, David, Palsson, Bernhard O.

“…Current machine learning classifiers have successfully been applied to whole-genome sequencing data to identify genetic determinants of antimicrobial…”
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Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance by Kavvas, Erol S., Catoiu, Edward, Mih, Nathan, Yurkovich, James T., Seif, Yara, Dillon, Nicholas, Heckmann, David, Anand, Amitesh, Yang, Laurence, Nizet, Victor, Monk, Jonathan M., Palsson, Bernhard O.

“…Mycobacterium tuberculosis is a serious human pathogen threat exhibiting complex evolution of antimicrobial resistance (AMR). Accordingly, the many publicly…”
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Machine learning with random subspace ensembles identifies antimicrobial resistance determinants from pan-genomes of three pathogens by Hyun, Jason C, Kavvas, Erol S, Monk, Jonathan M, Palsson, Bernhard O

“…The evolution of antimicrobial resistance (AMR) poses a persistent threat to global public health. Sequencing efforts have already yielded genome sequences for…”
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Experimental Evolution Reveals Unifying Systems-Level Adaptations but Diversity in Driving Genotypes by Kavvas, Erol S, Long, Christopher P, Sastry, Anand, Poudel, Saugat, Antoniewicz, Maciek R, Ding, Yang, Mohamed, Elsayed T, Szubin, Richard, Monk, Jonathan M, Feist, Adam M, Palsson, Bernhard O

“…Genotype-fitness maps of evolution have been well characterized for biological components, such as RNA and proteins, but remain less clear for systems-level…”
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Adaptive laboratory evolution for improved tolerance of isobutyl acetate in Escherichia coli by Matson, Morgan M., Cepeda, Mateo M., Zhang, Angela, Case, Anna E., Kavvas, Erol S., Wang, Xiaokang, Carroll, Austin L., Tagkopoulos, Ilias, Atsumi, Shota

“…Previously, Escherichia coli was engineered to produce isobutyl acetate (IBA). Titers greater than the toxicity threshold (3 g/L) were achieved by using…”
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Updated and standardized genome-scale reconstruction of Mycobacterium tuberculosis H37Rv, iEK1011, simulates flux states indicative of physiological conditions by Kavvas, Erol S, Seif, Yara, Yurkovich, James T, Norsigian, Charles, Poudel, Saugat, Greenwald, William W, Ghatak, Sankha, Palsson, Bernhard O, Monk, Jonathan M

“…The efficacy of antibiotics against M. tuberculosis has been shown to be influenced by experimental media conditions. Investigations of M. tuberculosis growth…”
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Evaluation of rate law approximations in bottom-up kinetic models of metabolism by Du, Bin, Zielinski, Daniel C, Kavvas, Erol S, Dräger, Andreas, Tan, Justin, Zhang, Zhen, Ruggiero, Kayla E, Arzumanyan, Garri A, Palsson, Bernhard O

“…The mechanistic description of enzyme kinetics in a dynamic model of metabolism requires specifying the numerical values of a large number of kinetic…”
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