Increased asymmetric dimethylarginine levels in severe transient tachypnea of the newborn

Objective: Nitric oxide (NO) is synthesized by NO synthase (NOS), and asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NOS. We aimed to investigate l -arginine and ADMA levels in transient tachypnea of the newborn (TTN) and their relationship with systolic pulmonary artery pressure (...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of perinatology Vol. 36; no. 6; pp. 459 - 462
Main Authors:	Isik, D U, Bas, A Y, Demirel, N, Kavurt, S, Aydemir, O, Kavurt, A V, Cetin, I
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01-06-2016 Nature Publishing Group
Subjects:	692/308/53/2422 692/699/1785 Analysis Arginine Arginine - analogs & derivatives Arginine - blood Asymmetry Blood Pressure Cardiology Care and treatment Disease Female Gestational age Health aspects Hospitals Humans Hypertension Hypoxia Infant, Newborn Influence Intensive care Male Medicine Medicine & Public Health Neonatal care Newborn babies Newborn infants Nitric oxide Nitric Oxide - biosynthesis Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Nitric-oxide synthase original-article Pathological physiology Patients Pediatric Surgery Pediatrics Pulmonary arteries Pulmonary artery Pulmonary Artery - physiology Severity of Illness Index Statistics as Topic Tachypnea Transient Tachypnea of the Newborn - blood Transient Tachypnea of the Newborn - diagnosis Transient Tachypnea of the Newborn - physiopathology Ventilators Womens health Ankara Turkey Turkey
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Objective: Nitric oxide (NO) is synthesized by NO synthase (NOS), and asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NOS. We aimed to investigate l -arginine and ADMA levels in transient tachypnea of the newborn (TTN) and their relationship with systolic pulmonary artery pressure (PAP) and disease severity. Study design: Infants born at ⩾35 weeks gestational age with clinical signs and chest X-ray findings consistent with TTN were enrolled; controls were recruited at the same time. l -arginine and ADMA levels were measured at 12 to 24 h (first samples) and at 48 to 72 h (second samples). Systolic PAP was evaluated on the second day. Patients were divided according to the duration of tachypnea and designated as group A (duration ⩽72 h) and group B (duration >72 h). Results: In the first samples, the ADMA levels were significantly higher in patients with TTN compared with controls ( P< 0.001). In the second samples, the ADMA levels were significantly higher in group B compared with that in group A ( P =0.019). In group A patients, the second ADMA levels were significantly lower compared with that in the first samples ( P< 0.001), whereas the second ADMA levels remained unchanged compared with the first samples in group B. Systolic PAP values were significantly higher in group B compared with that in group A patients ( P =0.033). Conclusion: Increased ADMA concentration may reduce NO synthesis, leading to increased PAP and thus longer duration of tachypnea.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0743-8346 1476-5543
DOI:	10.1038/jp.2016.9