Heterodyne frequency-domain multispectral diffuse optical tomography of breast cancer in the parallel-plane transmission geometry

Purpose: The authors introduce a state-of-the-art all-optical clinical diffuse optical tomography (DOT) imaging instrument which collects spatially dense, multispectral, frequency-domain breast data in the parallel-plate geometry. Methods: The instrument utilizes a CCD-based heterodyne detection sch...

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Bibliographic Details
Published in:	Medical physics (Lancaster) Vol. 43; no. 7; pp. 4383 - 4395
Main Authors:	Ban, H. Y., Schweiger, M., Kavuri, V. C., Cochran, J. M., Xie, L., Busch, D. R., Katrašnik, J., Pathak, S., Chung, S. H., Lee, K., Choe, R., Czerniecki, B. J., Arridge, S. R., Yodh, A. G.
Format:	Journal Article
Language:	English
Published:	United States American Association of Physicists in Medicine 01-07-2016
Subjects:	60 APPLIED LIFE SCIENCES Aged Biological material, e.g. blood, urine; Haemocytometers biological tissues biomedical measurement biomedical optical imaging BIOMEDICAL RADIOGRAPHY breast cancer imaging Breast Neoplasms - diagnostic imaging cancer CCD‐based optical tomography instrumentation CHARGE-COUPLED DEVICES COMPUTERIZED TOMOGRAPHY diffuse optical tomography Digital computing or data processing equipment or methods, specially adapted for specific applications EMERGING IMAGING AND THERAPY MODALITIES Equipment Design Female heterodyne detection Heterodyne detectors Humans Image data processing or generation, in general Image detection systems image reconstruction image segmentation Imaging, Three-Dimensional - methods Magnetic resonance imaging MAMMARY GLANDS Mammography - instrumentation Mammography - methods Measuring for diagnostic purposes; Identification of persons Medical image contrast medical image processing Medical image reconstruction Models, Anatomic NEOPLASMS NMR IMAGING optical mammography optical tomography phantoms Phantoms, Imaging RADIATION PROTECTION AND DOSIMETRY Reconstruction SCATTERING Segmentation SPATIAL RESOLUTION Tissues Tomography, Optical - instrumentation Tomography, Optical - methods tumours Visual imaging breast cancer imaging diffuse optical tomography CCD-based optical tomography instrumentation optical mammography
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Summary:	Purpose: The authors introduce a state-of-the-art all-optical clinical diffuse optical tomography (DOT) imaging instrument which collects spatially dense, multispectral, frequency-domain breast data in the parallel-plate geometry. Methods: The instrument utilizes a CCD-based heterodyne detection scheme that permits massively parallel detection of diffuse photon density wave amplitude and phase for a large number of source–detector pairs (106). The stand-alone clinical DOT instrument thus offers high spatial resolution with reduced crosstalk between absorption and scattering. Other novel features include a fringe profilometry system for breast boundary segmentation, real-time data normalization, and a patient bed design which permits both axial and sagittal breast measurements. Results: The authors validated the instrument using tissue simulating phantoms with two different chromophore-containing targets and one scattering target. The authors also demonstrated the instrument in a case study breast cancer patient; the reconstructed 3D image of endogenous chromophores and scattering gave tumor localization in agreement with MRI. Conclusions: Imaging with a novel parallel-plate DOT breast imager that employs highly parallel, high-resolution CCD detection in the frequency-domain was demonstrated.
Bibliography:	H. Y. Ban, M. Schweiger, and V. C. Kavuri contributed equally to this work. Author to whom correspondence should be addressed. Electronic mail venk@physics.upenn.edu ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 Author to whom correspondence should be addressed. Electronic mail: venk@physics.upenn.edu
ISSN:	0094-2405 2473-4209
DOI:	10.1118/1.4953830