Combined extracts of Moringa oleifera, Murraya koeingii leaves, and Curcuma longa rhizome increases energy expenditure and controls obesity in high-fat diet-fed rats

Combined extracts of Moringa oleifera, Murraya koeingii leaves, and Curcuma longa rhizome increases energy expenditure and controls obesity in high-fat diet-fed rats

Abstract Background LI85008F is a proprietary combination of leaf extracts of Moringa oleifera , Murraya koeingii , and extract of Curcuma longa rhizome. This herbal extract combination is an effective weight loss supplement for overweight and obese subjects. The present study aimed to investigate t...

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Published in:Lipids in health and disease Vol. 19; no. 1; pp. 1 - 198
Main Authors: Kundimi, Sreenath, Kavungala, Krishna Chaitanya, Sinha, Swaraj, Tayi, Venkata Narasimha Rao, Kundurthi, Nagendra Rao, Golakoti, Trimurtulu, Davis, Barbara, Sengupta, Krishanu
Format: Journal Article
Language:English
Published: London BioMed Central Ltd 28-08-2020
BioMed Central
BMC
Subjects:
Adipocytes
Adipokine
Adipose tissue
Body fat
Body mass index
Body weight
Body weight gain
Body weight loss
Calorimetry
Carbon dioxide
Carboxymethylcellulose
Cell size
Cholesterol
Curcuma longa
Diet
Diet-induced obesity
Dietary supplements
Energy
Energy expenditure
Energy metabolism
Ethanol
Food
Functional foods & nutraceuticals
Hepatocytes
Herbal medicine
High fat diet
Laboratories
Leaves
Leptin
LI85008F
Lipogenesis
Liver
Metabolism
Moringa oleifera
Murraya
Obesity
Overweight
Physiological aspects
Plant extracts
Raw materials
Resting energy expenditure
Rhizomes
Triglycerides
Uncoupling protein-1
United States > US
Germany
Spain
India
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Summary:Abstract Background LI85008F is a proprietary combination of leaf extracts of Moringa oleifera , Murraya koeingii , and extract of Curcuma longa rhizome. This herbal extract combination is an effective weight loss supplement for overweight and obese subjects. The present study aimed to investigate the thermogenic potential of the LI85008F in high-fat diet (HFD)-induced obese Sprague Dawley rats. Methods Seven rats received a regular diet (RD), and twenty-one rats received a high-fat diet (HFD) for 56 days. On day 28, the HFD-fed rats were randomized into three groups ( n  = 7). Starting from day 29 through day 56, one HFD-fed group received daily oral gavage of 0.5% Carboxymethylcellulose Sodium (CMC) alone (HFD), and the remaining two groups received 100 and 250 mg/kg LI85008F (LI85008F-100 and LI85008F-250, respectively). Body weight, fat mass, fat cell size, liver weight, liver triglyceride were measured. The energy metabolism parameters were measured using indirect calorimetry. In serum, the metabolic and endocrine markers were analyzed. The adipogenic and thermoregulatory proteins expression in the white adipose tissue (WAT) were analyzed using an immunoblot assay. Results Supplementation with both doses of LI85008F significantly increased resting energy expenditure (REE) in the obese rats. The LI85008F-250 rats showed significant up-regulation of uncoupling protein-1 (UCP-1) expression, as compared with the HFD rats. LI85008F significantly reduced body weight gain, fat mass, fat cell size, liver weight, and hepatic triglycerides. Serum triglyceride, total cholesterol, glucose, leptin, and fat cell markers were significantly reduced in LI85008F-supplemented rats compared to the HFD rats. Conclusion The present data suggest that LI85008F reduces body fat mass and controls body weight gain via increasing energy metabolism in combination with reduced lipogenesis in diet-fed obese rats.
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ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-020-01376-7