Search Results - "Kavlock, Robert J"

Improving the human hazard characterization of chemicals: a Tox21 update by Tice, Raymond R, Austin, Christopher P, Kavlock, Robert J, Bucher, John R

“…In 2008, the National Institute of Environmental Health Sciences/National Toxicology Program, the U.S. Environmental Protection Agency's National Center for…”
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Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis by Smith, Martyn T, Guyton, Kathryn Z, Gibbons, Catherine F, Fritz, Jason M, Portier, Christopher J, Rusyn, Ivan, DeMarini, David M, Caldwell, Jane C, Kavlock, Robert J, Lambert, Paul F, Hecht, Stephen S, Bucher, John R, Stewart, Bernard W, Baan, Robert A, Cogliano, Vincent J, Straif, Kurt

“…A recent review by the International Agency for Research on Cancer (IARC) updated the assessments of the > 100 agents classified as Group 1, carcinogenic to…”
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The Tox21 robotic platform for the assessment of environmental chemicals – from vision to reality by Attene-Ramos, Matias S., Miller, Nicole, Huang, Ruili, Michael, Sam, Itkin, Misha, Kavlock, Robert J., Austin, Christopher P., Shinn, Paul, Simeonov, Anton, Tice, Raymond R., Xia, Menghang

“…•The Tox21 effort is to advance in vitro toxicological testing in the 21st century.•Tox21 chemical library contains approximately 10,000 environmental…”
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Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data by Reif, David M., Martin, Matthew T., Tan, Shirlee W., Houck, Keith A., Judson, Richard S., Richard, Ann M., Knudsen, Thomas B., Dix, David J., Kavlock, Robert J.

“…Background: The prioritization of chemicals for toxicity testing is a primary goal of the U.S. Environmental Protection Agency (EPA) ToxCast™ program. Phase I…”
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The ToxCast Program for Prioritizing Toxicity Testing of Environmental Chemicals by Dix, David J., Houck, Keith A., Martin, Matthew T., Richard, Ann M., Setzer, R. Woodrow, Kavlock, Robert J.

“…The U.S. Environmental Protection Agency (EPA) is developing methods for utilizing computational chemistry, high-throughput screening (HTS), and various…”
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Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment by Wetmore, Barbara A., Wambaugh, John F., Ferguson, Stephen S., Sochaski, Mark A., Rotroff, Daniel M., Freeman, Kimberly, Clewell, Harvey J., Dix, David J., Andersen, Melvin E., Houck, Keith A., Allen, Brittany, Judson, Richard S., Singh, Reetu, Kavlock, Robert J., Richard, Ann M., Thomas, Russell S.

“…High-throughput in vitro toxicity screening can provide an efficient way to identify potential biological targets for chemicals. However, relying on nominal…”
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Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors by Huang, Ruili, Xia, Menghang, Cho, Ming-Hsuang, Sakamuru, Srilatha, Shinn, Paul, Houck, Keith A., Dix, David J., Judson, Richard S., Witt, Kristine L., Kaylock, Robert J., Tice, Raymond R., Austin, Christopher P.

“…Background: The large and increasing number of chemicals released into the environment demands more efficient and cost-effective approaches for assessing…”
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Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway by Huang, Ruili, Sakamuru, Srilatha, Martin, Matt T., Reif, David M., Judson, Richard S., Houck, Keith A., Casey, Warren, Hsieh, Jui-Hua, Shockley, Keith R., Ceger, Patricia, Fostel, Jennifer, Witt, Kristine L., Tong, Weida, Rotroff, Daniel M., Zhao, Tongan, Shinn, Paul, Simeonov, Anton, Dix, David J., Austin, Christopher P., Kavlock, Robert J., Tice, Raymond R., Xia, Menghang

“…The U.S. Tox21 program has screened a library of approximately 10,000 (10K) environmental chemicals and drugs in three independent runs for estrogen receptor…”
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Predictive Models of Prenatal Developmental Toxicity from ToxCast High-Throughput Screening Data by Sipes, Nisha S., Martin, Matthew T., Reif, David M., Kleinstreuer, Nicole C., Judson, Richard S., Singh, Amar V., Chandler, Kelly J., Dix, David J., Kavlock, Robert J., Knudsen, Thomas B.

“…Environmental Protection Agency's ToxCast project is profiling the in vitro bioactivity of chemicals to assess pathway-level and cell-based signatures that…”
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Toxicity Testing in the 21st Century: Implications for Human Health Risk Assessment by Kavlock, Robert J, Austin, Christopher P, Tice, Raymond R

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Profiling Chemicals Based on Chronic Toxicity Results from the U.S. EPA ToxRef Database by Martin, Matthew T., Judson, Richard S., Reif, David M., Kavlock, Robert J., Dix, David J.

“…Background: Thirty years of pesticide registration toxicity data have been historically stored as hardcopy and scanned documents by the U.S. Environmental…”
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Estimating Toxicity-Related Biological Pathway Altering Doses for High-Throughput Chemical Risk Assessment by Judson, Richard S, Kavlock, Robert J, Setzer, R. Woodrow, Cohen Hubal, Elaine A, Martin, Matthew T, Knudsen, Thomas B, Houck, Keith A, Thomas, Russell S, Wetmore, Barbara A, Dix, David J

“…We describe a framework for estimating the human dose at which a chemical significantly alters a biological pathway in vivo, making use of in vitro assay data…”
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Impact of Environmental Chemicals on Key Transcription Regulators and Correlation to Toxicity End Points within EPA’s ToxCast Program by Martin, Matthew T, Dix, David J, Judson, Richard S, Kavlock, Robert J, Reif, David M, Richard, Ann M, Rotroff, Daniel M, Romanov, Sergei, Medvedev, Alexander, Poltoratskaya, Natalia, Gambarian, Maria, Moeser, Matt, Makarov, Sergei S, Houck, Keith A

“…Exposure to environmental chemicals adds to the burden of disease in humans and wildlife to a degree that is difficult to estimate and, thus, mitigate. The…”
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Analysis of Eight Oil Spill Dispersants Using Rapid, In Vitro Tests for Endocrine and Other Biological Activity by Judson, Richard S, Martin, Matthew T, Reif, David M, Houck, Keith A, Knudsen, Thomas B, Rotroff, Daniel M, Xia, Menghang, Sakamuru, Srilatha, Huang, Ruili, Shinn, Paul, Austin, Christopher P, Kavlock, Robert J, Dix, David J

“…The Deepwater Horizon oil spill has led to the use of >1 M gallons of oil spill dispersants, which are mixtures of surfactants and solvents. Because of this…”
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Using nuclear receptor activity to stratify hepatocarcinogens by Shah, Imran, Houck, Keith, Judson, Richard S, Kavlock, Robert J, Martin, Matthew T, Reif, David M, Wambaugh, John, Dix, David J

“…Nuclear receptors (NR) are a superfamily of ligand-activated transcription factors that control a range of cellular processes. Persistent stimulation of some…”
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Understanding mechanisms of toxicity: Insights from drug discovery research by Houck, Keith A., Kavlock, Robert J.

“…Toxicology continues to rely heavily on use of animal testing for prediction of potential for toxicity in humans. Where mechanisms of toxicity have been…”
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In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis by Kleinstreuer, Nicole C, Dix, David J, Houck, Keith A, Kavlock, Robert J, Knudsen, Thomas B, Martin, Matthew T, Paul, Katie B, Reif, David M, Crofton, Kevin M, Hamilton, Kerry, Hunter, Ronald, Shah, Imran, Judson, Richard S

“…Thousands of untested chemicals in the environment require efficient characterization of carcinogenic potential in humans. A proposed solution is rapid testing…”
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Computational Toxicology—A State of the Science Mini Review by Kavlock, Robert J., Ankley, Gerald, Blancato, Jerry, Breen, Michael, Conolly, Rory, Dix, David, Houck, Keith, Hubal, Elaine, Judson, Richard, Rabinowitz, James, Richard, Ann, Setzer, R. Woodrow, Shah, Imran, Villeneuve, Daniel, Weber, Eric

“…Advances in computer sciences and hardware combined with equally significant developments in molecular biology and chemistry are providing toxicology with a…”
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Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB by Knudsen, Thomas B., Martin, Matthew T., Kavlock, Robert J., Judson, Richard S., Dix, David J., Singh, Amar V.

“…As the primary source for regulatory developmental toxicity information, prenatal studies characterize maternal effects and fetal endpoints including…”
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Accelerating the Pace of Chemical Risk Assessment by Kavlock, Robert J, Bahadori, Tina, Barton-Maclaren, Tara S, Gwinn, Maureen R, Rasenberg, Mike, Thomas, Russell S

“…Changes in chemical regulations worldwide have increased the demand for new data on chemical safety. New approach methodologies (NAMs) are defined broadly here…”
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