Search Results - "Kavanagh, John J."

Anticancer therapy targeting the apoptotic pathway by Hu, Wei, Kavanagh, John J

“…Apoptosis, or programmed cell death, has an essential role in controlling cell number in many developmental and physiological settings and in…”
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Hormonal therapy for recurrent low-grade serous carcinoma of the ovary or peritoneum by Gershenson, David M, Sun, Charlotte C, Iyer, Revathy B, Malpica, Anais L, Kavanagh, John J, Bodurka, Diane C, Schmeler, Kathleen, Deavers, Michael

“…Abstract Objective To determine whether hormonal therapies have efficacy in patients with recurrent low-grade serous carcinoma of the ovary or peritoneum…”
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Ovarian cancer, the coagulation pathway, and inflammation by Wang, Xipeng, Wang, Ena, Kavanagh, John J, Freedman, Ralph S

“…Epithelial ovarian cancer (EOC) represents the most frequent cause of death in the United States from a cancer involving the female genital tract. Contributing…”
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Azacitidine enhances sensitivity of platinum-resistant ovarian cancer cells to carboplatin through induction of apoptosis by Li, Yanfang, MD, Hu, Wei, MD, PhD, Shen, De-Yu, MS, Kavanagh, John J., MD, Fu, Siqing, MD, PhD

“…Objective The objective of the study was to investigate whether azacitidine sensitizes platinum-resistant ovarian cancer cells to carboplatin and the possible…”
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Targeted therapies for rare gynaecological cancers by Manchana, Tarinee, MD, Ittiwut, Chupong, PhD, Mutirangura, Apiwat, Prof, Kavanagh, John J, Prof

“…Summary Some gynaecological cancers are uncommon, such as sex cord-stromal tumours, malignant germ-cell tumours, vulvar carcinoma, melanoma of the female…”
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An Assessment of the Utilization of Complementary and Alternative Medication in Women With Gynecologic or Breast Malignancies by NAVO, Marisa A, PHAN, Julie, SMITH, Judith A, VAUGHAN, Christy, PALMER, J. Lynn, MICHAUD, Laura, JONES, Kellie L, BODURKA, Diane C, BASEN-ENGQUIST, Karen, HORTOBAGYI, Gabriel N, KAWINAGH, John J

“…To describe and assess the current utilization of complementary and alternative medicines (CAMs) in women with a diagnosis of either gynecologic or breast…”
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Corrigendum: Enhanced Cytotoxic Effects of Combined Valproic Acid and the Aurora Kinase Inhibitor VE465 on Gynecologic Cancer Cells by Li, Yanfang, Liu, Tao, Ivan, Cristina, Huang, Jie, Shen, De-Yu, Kavanagh, John J, Bast, Jr, Robert C, Fu, Siqing, Hu, Wei, Sood, Anil K

“…[This corrects the article on p. 58 in vol. 3, PMID: 23519775.]…”
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Efficacy of letrozole in the treatment of recurrent platinum- and taxane-resistant high-grade cancer of the ovary or peritoneum by Ramirez, Pedro T, Schmeler, Kathleen M, Milam, Michael R, Slomovitz, Brian M, Smith, Judith A, Kavanagh, John J, Deavers, Michael, Levenback, Charles, Coleman, Robert L, Gershenson, David M

“…Abstract Objective To evaluate the efficacy and safety of letrozole in patients with recurrent platinum- and taxane-resistant estrogen receptor-positive (ER+)…”
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Insulin-like growth factor binding protein 2 promotes ovarian cancer cell invasion by Lee, Eun-Ju, Mircean, Cristian, Shmulevich, Ilya, Wang, Huamin, Liu, Jinsong, Niemistö, Antti, Kavanagh, John J, Lee, Je-Ho, Zhang, Wei

“…Insulin-like growth factor binding protein 2 (IGFBP2) is overexpressed in ovarian malignant tissues and in the serum and cystic fluid of ovarian cancer…”
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Enhanced Cytotoxic Effects of Combined Valproic Acid and the Aurora Kinase Inhibitor VE465 on Gynecologic Cancer Cells by Li, Yanfang, Liu, Tao, Ivan, Cristina, Huang, Jie, Shen, De-Yu, Kavanagh, John J, Bast, Jr, Robert C, Fu, Siqing, Hu, Wei, Sood, Anil K

“…Increasing evidence shows that targeting epigenetic changes including acetylation and deacetylation of core nucleosomal histones as well as Aurora kinases hold…”
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Aurora kinase inhibitor VE 465 synergistically enhances cytotoxicity of carboplatin in ovarian cancer cells through induction of apoptosis and downregulation of histone 3 by Fu, Siqing, li, Yanfang, Huang, Jie, Liu, Tao, Hong, Zhen, Chen, Aiping, Bast, Robert C., Kavanagh, John J., Gershenson, David M., Sood, Anil K., Hu, Wei

“…Aurora kinases are essential for regulation of chromosome segregation and cytokinesis during mitosis and play a role in growth and progression of human tumors,…”
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Phase II Trial of Irinotecan in Patients With Metastatic Epithelial Ovarian Cancer or Peritoneal Cancer by BODURKA, Diane C, LEVENBACK, Charles, WOLF, Judith K, GANO, Jacalyn, WHARTON, J. Taylor, KAVANAGH, John J, GERSHENSON, David M

“…To evaluate the efficacy and toxicity of irinotecan in patients with metastatic platinum-resistant or platinum-refractory epithelial ovarian cancer or primary…”
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Pilot Study of Flt3 Ligand Comparing Intraperitoneal with Subcutaneous Routes on Hematologic and Immunologic Responses in Patients with Peritoneal Carcinomatosis and Mesotheliomas by FREEDMAN, Ralph S, VADHAN-RAJ, Saroj, GARCIA, Michael E, BUTTS, Cherie, SAVARY, Cherylyn, MELICHAR, Bohuslav, VERSCHRAEGEN, Claire, KAVANAGH, John J, HICKS, Marshall E, LEVY, Lawrence B, FOLLODER, Jody K

“…Purpose: This study compared the clinical toxicity and hematological effects of i.p. and s.c. administration of fms-like tyrosine kinase-3-ligand (Flt3-L;…”
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Nuclear cyclin B1 is overexpressed in low-malignant-potential ovarian tumors but not in epithelial ovarian cancer by Zheng, Hong, MD, PhD, Hu, Wei, MD, PhD, Deavers, Michael T., MD, Shen, De-Yu, MS, Fu, Siqing, MD, PhD, Li, Yan-Fang, MD, Kavanagh, John J., MD

“…Objective To investigate the role of cyclin G1 and cyclin B1 in ovarian tumorigenesis. Study Design We examined cyclin B1 and G1 expression in 58 epithelial…”
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Phase I Study of Intraperitoneal Recombinant Human Interleukin 12 in Patients with Müllerian Carcinoma, Gastrointestinal Primary Malignancies, and Mesothelioma by LENZI, Renato, ROSENBLUM, Michael, PLATSOUCAS, Chris D, ABBRUZZESE, James L, FREEDMAN, Ralph S, VERSCHRAEGEN, Claire, KUDELKA, Andrzej P, KAVANAGH, John J, HICKS, Marshall E, LANG, Eric A, NASH, Michael A, LEVY, Lawrence B, GARCIA, Michael E

“…Purpose: The purpose is to determine dose-limiting toxicity, pharmacokinetics,pharmacodynamics, and immunobiology after i.p. injections of recombinant human…”
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Recurrent low-grade serous ovarian carcinoma is relatively chemoresistant by Gershenson, David M, Sun, Charlotte C, Bodurka, Diane, Coleman, Robert L, Lu, Karen H, Sood, Anil K, Deavers, Michael, Malpica, Anais L, Kavanagh, John J

“…Abstract Purpose Previous studies have suggested that low-grade serous ovarian carcinoma is more chemoresistant to first-line or neoadjuvant chemotherapy than…”
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Phase 1b‐2a study to reverse platinum resistance through use of a hypomethylating agent, azacitidine, in patients with platinum‐resistant or platinum‐refractory epithelial ovarian cancer by Fu, Siqing, Hu, Wei, Iyer, Revathy, Kavanagh, John J., Coleman, Robert L., Levenback, Charles F., Sood, Anil K., Wolf, Judith K., Gershenson, David M., Markman, Maurie, Hennessy, Bryan T., Kurzrock, Razelle, Bast, Robert C.

“…BACKGROUND: Sequential treatment with azacitidine can induce re‐expression of epigenetically silenced genes through genomic DNA hypomethylation and reverse…”
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Phase 2 study of canfosfamide in combination with pegylated liposomal doxorubicin in platinum and paclitaxel refractory or resistant epithelial ovarian cancer by Kavanagh, John J, Levenback, Charles F, Ramirez, Pedro T, Wolf, Judith L, Moore, Carla L, Jones, Marsha R, Meng, Lisa, Brown, Gail L, Bast, Jr, Robert C

“…Canfosfamide is a novel glutathione analog activated by glutathione S-transferase P1-1. This study evaluated the safety and efficacy of canfosfamide in…”
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Proteomic identification of heat shock protein 70 as a candidate target for enhancing apoptosis induced by farnesyl transferase inhibitor by Hu, Wei, Wu, WeiGuo, Verschraegen, Claire F., Chen, Ling, Mao, Li, Yeung, Sai-Ching Jim, Kudelka, Andrzej P., Freedman, Ralph S., Kavanagh, John J.

“…Farnesyl transferase inhibitors (FTIs) are novel antitumor drugs with clinical activity. FTIs inhibit cell growth not only by preventing direct Ras…”
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Sustained Complete Response after Maintenance Therapy with Topotecan and Erlotinib for Recurrent Cervical Cancer with Distant Metastases by Callegaro-Filho, Donato, Kavanagh, John J., Nick, Alpa M., Ramirez, Pedro T., Schmeler, Kathleen M.

“…Introduction: Recurrent cervical cancer is associated with a poor prognosis. Most treatment responses are partial and of short duration. The development of new…”
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