Influence of maternal labor time on delta-aminolevulinate dehydratase enzyme activity and markers of oxidative stress in newborns

Influence of maternal labor time on delta-aminolevulinate dehydratase enzyme activity and markers of oxidative stress in newborns

The purpose is to determine markers of oxidative stress related to the longer and shorter duration of labor (DOL) of pregnant women in the umbilical cord blood of neonates, not yet studied. Blood samples from the umbilical cord were collected from pregnant women with normal delivery and classified a...

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Bibliographic Details
Published in:Scandinavian journal of clinical and laboratory investigation Vol. 79; no. 7; pp. 496 - 501
Main Authors: Vendrame, Silmara Ana, de Lucca, Leidiane, de Paula, Hellen Lopes, Stein, Carolina dos Santos, Paz, Monique Soares, Kavalco, Tatiana Frehner, Gallarreta, Francisco Maximiliano Pancich, Moresco, Rafael Noal, Gonçalves, Thissiane de Lima
Format: Journal Article
Language:English
Published: England Taylor & Francis 03-10-2019
Subjects:
childbirth
newborn
Oxidative profile
δ-ALA-D
δ-ALA-D
childbirth
newborn
Oxidative profile
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Summary:The purpose is to determine markers of oxidative stress related to the longer and shorter duration of labor (DOL) of pregnant women in the umbilical cord blood of neonates, not yet studied. Blood samples from the umbilical cord were collected from pregnant women with normal delivery and classified according to DOL in two groups: a group with DOL less than 310 min (n = 33) and a group with DOL greater than or equal to 310 min (n = 35). The oxidative stress parameters were analyzed by the quantification of thiobarbituric acid reactive substances (TBARS), nitrate/nitrite (NOx), protein thiol groups (P-SH) and non-protein (NP-SH), vitamin C and plasma iron reduction capacity (FRAP), in addition to the activity of the enzyme delta-aminolevulinate dehydratase (δ-ALA-D). The activity of the δ-ALA-D enzyme was shown to be decreased in longer DOL, however, the oxidant parameters and antioxidants were higher in the longer DOL, with the exception of NP-SH that was lower. The longer maternal DOL time is related to the alteration of δ-ALA-D enzyme activity and other parameters in neonates, suggesting an increase in the passage of maternal oxidative markers by umbilical cord blood.
ISSN:0036-5513
1502-7686
DOI:10.1080/00365513.2019.1661010