Search Results - "Kauvar, Lawrence"

Human antibody repertoire frequently includes antibodies to a bacterial biofilm associated protein by Ryser, Stefan, Tenorio, Edgar, Estellés, Angeles, Kauvar, Lawrence M

“…We have previously described a native human monoclonal antibody, TRL1068, that disrupts bacterial biofilms by extracting from the biofilm matrix key…”
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Advances in the Development of Therapeutics for Cytomegalovirus Infections by Acosta, Edward, Bowlin, Terry, Brooks, Jennifer, Chiang, Lillian, Hussein, Islam, Kimberlin, David, Kauvar, Lawrence M, Leavitt, Randi, Prichard, Mark, Whitley, Richard

“…Abstract The development of therapeutics for cytomegalovirus (CMV) infections, while progressing, has not matched the pace of new treatments of human…”
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A Native Human Monoclonal Antibody Targeting HCMV gB (AD-2 Site I) by McVoy, Michael M, Tenorio, Edgar, Kauvar, Lawrence M

“…Hyperimmune globulin (HIG) has shown efficacy against human cytomegalovirus (HCMV) for both transplant and congenital transmission indications. Replicating…”
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Role of Type I Interferon (IFN) in the Respiratory Syncytial Virus (RSV) Immune Response and Disease Severity by Hijano, Diego R, Vu, Luan D, Kauvar, Lawrence M, Tripp, Ralph A, Polack, Fernando P, Cormier, Stephania A

“…Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract disease in children <2 years of age. Increased morbidity and mortality…”
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Respiratory Syncytial Virus: Targeting the G Protein Provides a New Approach for an Old Problem by Tripp, Ralph A, Power, Ultan F, Openshaw, Peter J M, Kauvar, Lawrence M

“…Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection (LRTI) annually affecting >2 million children in the United States <5…”
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Intrauterine Growth Restriction Caused by Underlying Congenital Cytomegalovirus Infection by Pereira, Lenore, Petitt, Matthew, Fong, Alex, Tsuge, Mitsuru, Tabata, Takako, Fang-Hoover, June, Maidji, Ekaterina, Zydek, Martin, Zhou, Yan, Inoue, Naoki, Loghavi, Sanam, Pepkowitz, Samuel, Kauvar, Lawrence M., Ogunyemi, Dotun

“…Background. Human cytomegalovirus (HCMV) is the major viral etiology of congenital infection and birth defects. Fetal transmission is high (30%-40%) in primary…”
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High affinity anti-TIM-3 and anti-KIR monoclonal antibodies cloned from healthy human individuals by Ryser, Stefan, Estellés, Angeles, Tenorio, Edgar, Kauvar, Lawrence M, Gishizky, Mikhail L

“…We report here the cloning of native high affinity anti-TIM-3 and anti-KIR IgG monoclonal antibodies (mAbs) from peripheral blood mononuclear cells (PBMC) of…”
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Conformational Flexibility in Respiratory Syncytial Virus G Neutralizing Epitopes by Fedechkin, Stanislav O, George, Natasha L, Nuñez Castrejon, Ana M, Dillen, Joshua R, Kauvar, Lawrence M, DuBois, Rebecca M

“…Respiratory syncytial virus (RSV) is a top cause of severe lower respiratory tract disease and mortality in infants and the elderly. Currently, no vaccine or…”
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Impact of Antibodies and Strain Polymorphisms on Cytomegalovirus Entry and Spread in Fibroblasts and Epithelial Cells by Cui, Xiaohong, Freed, Daniel C, Wang, Dai, Qiu, Ping, Li, Fengsheng, Fu, Tong-Ming, Kauvar, Lawrence M, McVoy, Michael A

“…Cytomegalovirus (CMV) entry into fibroblasts differs from entry into epithelial cells. CMV also spreads cell to cell and can induce syncytia. To gain insights…”
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Human cytomegalovirus infection interferes with the maintenance and differentiation of trophoblast progenitor cells of the human placenta by Tabata, Takako, Petitt, Matthew, Zydek, Martin, Fang-Hoover, June, Larocque, Nicholas, Tsuge, Mitsuru, Gormley, Matthew, Kauvar, Lawrence M, Pereira, Lenore

“…Human cytomegalovirus (HCMV) is a major cause of birth defects that include severe neurological deficits, hearing and vision loss, and intrauterine growth…”
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Inhibition of human cytomegalovirus entry into mucosal epithelial cells by He, Li, Hertel, Laura, James, Claire D., Morgan, Iain M., Klingelhutz, Aloysius J., Fu, Tong-Ming, Kauvar, Lawrence M., McVoy, Michael A.

“…Human cytomegalovirus (CMV) causes serious developmental disabilities in newborns infected in utero following oral acquisition by the mother. Thus,…”
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Structure-Based Design and Antigenic Validation of Respiratory Syncytial Virus G Immunogens by Nuñez Castrejon, Ana M, O'Rourke, Sara M, Kauvar, Lawrence M, DuBois, Rebecca M

“…Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract disease of children, the elderly, and immunocompromised individuals…”
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HCMV infection of human trophoblast progenitor cells of the placenta is neutralized by a human monoclonal antibody to glycoprotein B and not by antibodies to the pentamer complex by Zydek, Martin, Petitt, Matthew, Fang-Hoover, June, Adler, Barbara, Kauvar, Lawrence M, Pereira, Lenore, Tabata, Takako

“…Human cytomegalovirus (HCMV) is the major viral cause of congenital infection and birth defects. Primary maternal infection often results in virus…”
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Phase 1 study of the pharmacokinetics and clinical proof-of-concept activity of a biofilm-disrupting human monoclonal antibody in patients with chronic prosthetic joint infection of the knee or hip by Conway, Janet, Delanois, Ronald E, Mont, Michael A, Stavrakis, Alexandra, McPherson, Edward, Stolarski, Edward, Incavo, Stephen, Oakes, Daniel, Salvagno, Ralph, Adams, John S, Kisch-Hancock, Adriane, Tenorio, Edgar, Leighton, Anton, Ryser, Stefan, Kauvar, Lawrence M, Bernthal, Nicholas M

“…We report the results of a first-in-human phase 1 clinical study to evaluate TRL1068, a native human monoclonal antibody that disrupts bacterial biofilms with…”
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Anti-G protein antibodies targeting the RSV G protein CX3C chemokine region improve the interferon response by Bergeron, Harrison C., Kauvar, Lawrence M., Tripp, Ralph A.

“…Background: Respiratory syncytial virus (RSV) is a poor inducer of antiviral interferon (IFN) responses which result in incomplete immunity and RSV disease…”
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Native Human Antibody to Shr Promotes Mice Survival After Intraperitoneal Challenge With Invasive Group A Streptococcus by Chatterjee, Nilanjana, Huang, Ya-Shu, Lyles, Kristin V, Morgan, Julie E, Kauvar, Lawrence M, Greer, Susanna F, Eichenbaum, Zehava

“…Abstract Background A vaccine against group A Streptococcus (GAS) has been actively pursued for decades. The surface receptor Shr is vital in GAS heme uptake…”
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Native Human Monoclonal Antibodies with Potent Cross-Lineage Neutralization of Influenza B Viruses by Vigil, Adam, Estélles, Angeles, Kauvar, Lawrence M, Johnson, Scott K, Tripp, Ralph A, Wittekind, Michael

“…Although antibodies that effectively neutralize a broad set of influenza viruses exist in the human antibody repertoire, they are rare. We used a single-cell…”
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A High-Affinity Native Human Antibody Disrupts Biofilm from Staphylococcus aureus Bacteria and Potentiates Antibiotic Efficacy in a Mouse Implant Infection Model by Estellés, Angeles, Woischnig, Anne-Kathrin, Liu, Keyi, Stephenson, Robert, Lomongsod, Evelene, Nguyen, Da, Zhang, Jianzhong, Heidecker, Manfred, Yang, Yifan, Simon, Reyna J, Tenorio, Edgar, Ellsworth, Stote, Leighton, Anton, Ryser, Stefan, Gremmelmaier, Nina Khanna, Kauvar, Lawrence M

“…Many serious bacterial infections are difficult to treat due to biofilm formation, which provides physical protection and induces a sessile phenotype…”
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A Human Biofilm-Disrupting Monoclonal Antibody Potentiates Antibiotic Efficacy in Rodent Models of both Staphylococcus aureus and Acinetobacter baumannii Infections by Xiong, Yan Q, Estellés, Angeles, Li, L, Abdelhady, W, Gonzales, R, Bayer, Arnold S, Tenorio, Edgar, Leighton, Anton, Ryser, Stefan, Kauvar, Lawrence M

“…Many serious bacterial infections are antibiotic refractory due to biofilm formation. A key structural component of biofilm is extracellular DNA, which is…”
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Immune Prophylaxis Targeting the Respiratory Syncytial Virus (RSV) G Protein by Bergeron, Harrison C, Murray, Jackelyn, Arora, Aakash, Nuñez Castrejon, Ana M, DuBois, Rebecca M, Anderson, Larry J, Kauvar, Lawrence M, Tripp, Ralph A

“…The respiratory syncytial virus (RSV) causes significant respiratory disease in young infants and the elderly. Immune prophylaxis in infants is currently…”
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