Search Results - "Kauvar, L M"

Tumor efficacy and bone marrow-sparing properties of TER286, a cytotoxin activated by glutathione S-transferase by MORGAN, A. S, SANDERSON, P. E, BROBERG, U, MANNERVIK, B, HENNER, W. D, KAUVAR, L. M, BORCH, R. F, TEW, K. D, NIITSU, Y, TAKAYAMA, T, VON HOFF, D. D, IZBICKA, E, MANGOLD, G, PAUL, C

“…TER286 is a latent drug activated by human glutathione S-transferase (GST) isoforms P1-1 and A1-1 to produce a nitrogen mustard alkylating agent. M7609 human…”
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The engrailed locus of Drosophila: structural analysis of an embryonic transcript by Poole, S J, Kauvar, L M, Drees, B, Kornberg, T

“…cDNA clones originating from the engrailed gene of Drosophila have been isolated from recombinant phage libraries that were made using poly(A)+ RNA extracted…”
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Glutathione-S-transferase Activates Novel Alkylating Agents by Lyttle, Matthew H, Satyam, Apparao, Hocker, Michael D, Bauer, Karin E, Caldwell, Colby G, Hui, Hon C, Morgan, Amy S, Mergia, Alemayehu, Kauvar, Lawrence M

“…Alkylating agents which are activated by glutathion-S-transferases (GSTs) have been designed and synthesized. The model compound…”
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Mutagenesis using trinucleotide beta-cyanoethyl phosphoramidites by Lyttle, M H, Napolitano, E W, Calio, B L, Kauvar, L M

“…There is no easy way to selectively introduce mixtures of codon triplets into mutagenesis libraries. Solid-phase-supported DNA synthesis using successive…”
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Variability of glutathione S-transferase isoenzyme patterns in matched normal and cancer human breast tissue by Kelley, M K, Engqvist-Goldstein, A, Montali, J A, Wheatley, J B, Schmidt, Jr, D E, Kauvar, L M

“…The determination of GST levels in blood has been proposed to a marker of tumour burden in general, whereas level of the P1 isoenzyme has been identified as a…”
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Isozyme specificity of novel glutathione-S-transferase inhibitors by FLATGAARD, J. E, BAUER, K. E, KAUVAR, L. M

“…A systematically diversified set of peptide analogs of the reaction product of glutathione with an electrophilic substrate have been tested as isozyme-specific…”
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Spin dialysis desalting of small protein samples in a membrane-bottomed 96-well microplate by Berry, C O, Kauvar, L M

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Glutathione analogue sorbents selectively bind glutathione S-transferase isoenzymes by CASTRO, V. M, KELLEY, M. K, ENGQVIST-GOLDSTEIN, Å, KAUVAR, L. M

“…Novel affinity sorbents for glutathione S-transferases (GSTs) were created by binding glutathione (GSH) analogues to Sepharose 6B. The GSH molecule was…”
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Defective cyclic adenosine 3':5'-monophosphate phosphodiesterase in the Drosophila memory mutant dunce by Kauvar, LM

“…A detailed characterization of the cyclic nucleotide phosphodiesterase (PDEs) from normal Drosophila melanogaster was made, including purification of the two…”
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Isozyme-specific glutathione S-transferase inhibitors potentiate drug sensitivity in cultured human tumor cell lines by MORGAN, A. S, CIACCIO, P. J, TEW, K. D, KAUVAR, L. M

“…Novel glutathione (GSH) analogs, previously shown to inhibit glutathione S-transferase (GST) activity at about 1 microM in vitro, were tested for their ability…”
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Pharmacological regulation of network kinetics by protein kinase C localization by Mochly-Rosen, Daria, Kauvar, Lawrence M.

“…Protein kinase C (PKC) is a conserved family of 11 serine/threonine kinases. Most cell types express multiple members of the family. Because the catalytic…”
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"Paralogs", sorbent families for protein separations by Benedek, K, Várkonyi, A, Hughes, B, Zabel, K, Kauvar, L M

“…Novel peptide-based (paralog) sorbents are evaluated with respect to performance, reproducibility and reusability in a 96-well test plate screening format, and…”
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Paralog chromatography by Kauvar, L M, Cheung, P Y, Gomer, R H, Fleischer, A A

“…As a mixed mode ligand, a small peptide can mimic an antibody's paratope (antigen recognition site). This report describes the construction of a representative…”
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Amino acid preferences at protein binding sites by Villar, Hugo O., Kauvar, Lawrence M.

“…An analysis of the amino acid distribution at protein binding sites was carried out using 50 diverse macromolecules for which crystallographic data with a…”
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Direct Interaction in T-cells between θPKC and the Tyrosine Kinase p59fyn by Ron, Dorit, Napolitano, Eugene W., Voronova, Anna, Vasquez, Nicki J., Roberts, Doug N., Calio, Brenda L., Caothien, Roger H., Pettiford, Sherrie M., Wellik, Sarah, Mandac, Janis B., Kauvar, Lawrence M.

“…The protein kinase C (PKC) family has been clearly implicated in T-cell activation as have several nonreceptor protein-tyrosine kinases associated with the T-…”
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Deciphering cryptic similarities in protein binding sites by Kauvar, Lawrence M, Villar, Hugo O

“…Rapid expansion in the number of plausible drug targets arising from genomics research has created new pressures for increased efficiency in discovery of high…”
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Glutathione based approaches to improving cancer treatment by Kauvar, Lawrence M, Morgan, Amy S, Sanderson, Polly E, Henner, W.David

“…The use of cytotoxic chemotherapy for cancer therapy has been very successful in the treatment and often cure of patients with particular neoplasms, such as…”
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Peptide mimetic drugs: A comment on progress and prospects by Kauvar, Lawrence M

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Affinity Fingerprinting by Kauvar, Lawrence M

“…We often think that a ligand binding to its target is finding the key that fits a lock. While this simile is useful for describing the complementarity of…”
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The engrailed locus of Drosophila melanogaster: genetic, developmental, and molecular studies by Ali, Z, Drees, B, Coleman, K G, Gustavson, E, Karr, T L, Kauvar, L M, Poole, S J, Soeller, W, Weir, M P, Kornberg, T

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