Search Results - "Kaushal, Gur P."

Molecular Interactions Between Reactive Oxygen Species and Autophagy in Kidney Disease by Kaushal, Gur P, Chandrashekar, Kiran, Juncos, Luis A

“…Reactive oxygen species (ROS) are highly reactive signaling molecules that maintain redox homeostasis in mammalian cells. Dysregulation of redox homeostasis…”
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Autophagy Function and Regulation in Kidney Disease by Kaushal, Gur P, Chandrashekar, Kiran, Juncos, Luis A, Shah, Sudhir V

“…Autophagy is a dynamic process by which intracellular damaged macromolecules and organelles are degraded and recycled for the synthesis of new cellular…”
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Endoplasmic Reticulum Stress-Induced Autophagy Provides Cytoprotection from Chemical Hypoxia and Oxidant Injury and Ameliorates Renal Ischemia-Reperfusion Injury by Chandrika, Bhavya B, Yang, Cheng, Ou, Yang, Feng, Xiaoke, Muhoza, Djamali, Holmes, Alexandrea F, Theus, Sue, Deshmukh, Sarika, Haun, Randy S, Kaushal, Gur P

“…We examined whether endoplasmic reticulum (ER) stress-induced autophagy provides cytoprotection from renal tubular epithelial cell injury due to oxidants and…”
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ADAM10 Is the Major Sheddase Responsible for the Release of Membrane-associated Meprin A by Herzog, Christian, Haun, Randy S., Ludwig, Andreas, Shah, Sudhir V., Kaushal, Gur P.

“…Meprin A, composed of α and β subunits, is a membrane-bound metalloproteinase in renal proximal tubules. Meprin A plays an important role in tubular epithelial…”
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Carbamylated Low-Density Lipoprotein (cLDL)-Mediated Induction of Autophagy and Its Role in Endothelial Cell Injury by Bose, Chhanda, Shah, Sudhir V, Karaduta, Oleg K, Kaushal, Gur P

“…Patients with chronic kidney disease (CKD) have high risk of cardiovascular complications. Plasma levels of carbamylated proteins produced by urea-derived…”
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Autophagy delays apoptosis in renal tubular epithelial cells in cisplatin cytotoxicity by Kaushal, Gur P., Kaushal, Varsha, Herzog, Christian, Yang, Cheng

“…One of the major side effects of cisplatin chemotherapy is toxic acute kidney injury due to preferential accumulation of cisplatin in renal proximal tubule…”
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Challenges and Advances in the Treatment of AKI by KAUSHAL, Gur P, SHAH, Sudhir V

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Epigenetic regulation of KLK7 gene expression in pancreatic and cervical cancer cells by Raju, Ilangovan, Kaushal, Gur P, Haun, Randy S

“…Kallikrein-related peptidase 7 (KLK7) is a serine protease encoded within the kallikrein gene cluster located on human chromosome region 19q13.3-13.4. KLK7 is…”
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Autophagy in acute kidney injury by Kaushal, Gur P, Shah, Sudhir V

“…Autophagy is a conserved multistep pathway that degrades and recycles damaged organelles and macromolecules to maintain intracellular homeostasis. The…”
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Impact of Hydroxychloroquine on Atherosclerosis and Vascular Stiffness in the Presence of Chronic Kidney Disease by Shukla, Ashutosh M, Bose, Chhanda, Karaduta, Oleg K, Apostolov, Eugene O, Kaushal, Gur P, Fahmi, Tariq, Segal, Mark S, Shah, Sudhir V

“…Cardiovascular disease is the largest cause of morbidity and mortality among patients with chronic kidney disease (CKD) and end-stage kidney disease, with…”
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p53-dependent Caspase-2 Activation in Mitochondrial Release of Apoptosis-inducing Factor and Its Role in Renal Tubular Epithelial Cell Injury by Seth, Rohit, Yang, Cheng, Kaushal, Varsha, Shah, Sudhir V., Kaushal, Gur P.

“…We demonstrate the role of p53-mediated caspase-2 activation in the mitochondrial release of apoptosis-inducing factor (AIF) in cisplatin-treated renal tubular…”
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Apoptotic pathways in ischemic acute renal failure by Kaushal, Gur P., Basnakian, Alexei G., Shah, Sudhir V.

“…Apoptotic pathways in ischemic acute renal failure. The study of cell death has emerged as an important and exciting area of research in cell biology. Although…”
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Autophagy protects proximal tubular cells from injury and apoptosis by Kaushal, Gur P

“…Autophagy is upregulated during ischemia-reperfusion (IR)-induced and cisplatin-induced acute kidney injury (AKI). Proximal tubule-specific Atg7 knockout mice…”
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Fibrate prevents cisplatin-induced proximal tubule cell death by Nagothu, Kiran K., Bhatt, Renu, Kaushal, Gur P., Portilla, Didier

“…Fibrate prevents cisplatin-induced proximal tubule cell death. In previous studies we have shown that cisplatin inhibits peroxisome proliferator-activated…”
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Role and regulation of activation of caspases in cisplatin-induced injury to renal tubular epithelial cells by Kaushal, Gur P., Kaushal, Varsha, Hong, Xiaoman, Shah, Sudhir V.

“…Role and regulation of activation of caspases in cisplatin-induced injury to renal tubular epithelial cells. Cellular and molecular mechanisms responsible for…”
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Disruption of renal peritubular blood flow in lipopolysaccharide-induced renal failure: role of nitric oxide and caspases by Tiwari, Manish M, Brock, Robert W, Megyesi, Judit K, Kaushal, Gur P, Mayeux, Philip R

“…Acute renal failure (ARF) is a frequent and serious complication of endotoxemia caused by lipopolysaccharide (LPS) and contributes significantly to mortality…”
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Challenges and advances in the treatment of AKI by Kaushal, Gur P, Shah, Sudhir V

“…Treating or preventing AKI requires treating or preventing a rise in serum creatinine as well as the immediate and remote clinical consequences associated with…”
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Deletion of LOX-1 attenuates renal injury following angiotensin II infusion by Hu, Changping, Kang, Bum-Yong, Megyesi, Judit, Kaushal, Gur P., Safirstein, Robert L., Mehta, Jawahar L.

“…Angiotensin II upregulates the expression of LOX-1, a recently identified oxidized low-density lipoprotein receptor controlled by redox state which in turn…”
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Autophagy is associated with apoptosis in cisplatin injury to renal tubular epithelial cells by Yang, Cheng, Kaushal, Varsha, Shah, Sudhir V, Kaushal, Gur P

“…Autophagy has emerged as another major "programmed" mechanism to control life and death much like "programmed cell death" is for apoptosis in eukaryotes. We…”
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Role of meprin metalloproteinases in cytokine processing and inflammation by Herzog, Christian, Haun, Randy S., Kaushal, Gur P.

“…•Meprin metalloproteinases comprised of α and β subunits are widely expressed in mammalian cells.•Meprins proteolytically process many inflammatory cytokines…”
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