Search Results - "Kaur, Rajneet"
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1
Head-on collision of nonlinear excitations in electron beam superthermal plasma
Published in The European physical journal. D, Atomic, molecular, and optical physics (01-08-2023)“…This study presents the head-on collision of electron-acoustic (EA) multi-solitons in an unmagnetized plasma with cold electron fluid, an electron beam,…”
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2
Exploring Artificial Intelligence in Drug Discovery: A Comprehensive Review
Published in Archives of computational methods in engineering (01-06-2022)“…Drug discovery and development process is very lengthy, highly expensive and extremely complex in nature. Traditional methods involve expensive techniques and…”
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3
Enhancing biopharmaceutical attributes of phospholipid complex-loaded nanostructured lipidic carriers of mangiferin: Systematic development, characterization and evaluation
Published in International journal of pharmaceutics (25-02-2017)“…[Display omitted] Mangiferin (Mgf), largely expressed out from the leaves and stem bark of Mango, is a potent antioxidant. However, its in vivo activity gets…”
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4
Potential of Natural Biomaterials in Nano-scale Drug Delivery
Published in Current pharmaceutical design (01-01-2018)“…The usage of natural biomaterials or naturally derived materials intended for interface with biological systems has steadily increased in response to the high…”
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5
Engineered Site-specific Vesicular Systems for Colonic Delivery: Trends and Implications
Published in Current pharmaceutical design (01-01-2020)“…Steering drug-loaded, site-specific, coated lipid vesicles to the target receptor sites have the potential of plummeting adverse effects and improving the…”
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6
Impact of Mutations on the Conformational Transition from α‑Helix to β‑Sheet Structures in Arctic-Type Aβ40: Insights from Molecular Dynamics Simulations
Published in ACS omega (15-09-2020)“…The amyloid-β (Aβ) protein aggregation into toxic oligomers and fibrils has been recognized as a key player in the pathogenesis of Alzheimer’s disease. Recent…”
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7
An HPTLC densitometric method for simultaneous quantification of sorafenib tosylate and chrysin: Analytical method development, validation and applications
Published in Microchemical journal (01-03-2021)“…•Combination therapeutic strategy is a cornerstone of cancer therapy.•Sorafenib (SFN) and chrysin (CHR) demonstrate definitive synergistic potential.•Robust…”
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Unveiling the inhibitory mechanism of peptidomimetic inhibitor against Aβ42 aggregation and protofibril disaggregation by molecular dynamics
Published in Journal of molecular liquids (01-08-2021)“…The peptidomimetic compound C1 stabilized the non-aggregation-prone helical conformation of the Aβ42 monomer. C1 destabilized the S-shaped Aβ42 protofibril…”
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9
Studies on Effect of Stress Preconditioning in Restrain Stress-induced Behavioral Alterations
Published in YAKUGAKU ZASSHI (01-02-2010)“…Stress preconditioning has been documented to confer on gastroprotective effects on stress-induced gastric ulcerations. However, the effects of prior exposure…”
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10
Emerging Strategies and Challenges for Controlled Delivery of Taxanes: A Comprehensive Review
Published in Current drug metabolism (01-01-2015)“…Taxanes introduction in the mid 90 s leads to significant advancement as well as superlative improvement in the treatment of cancer. Since then, several…”
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11
Discovery of EGFR kinase’s T790M variant inhibitors through molecular dynamics simulations, PCA-based dimension reduction, and hierarchical clustering
Published in Structural chemistry (01-12-2022)“…Deregulation of epidermal growth factor receptors is one of the major causes of lung cancers, and its kinase has been targeted in associated therapy. Often,…”
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12
How L17A/F19A Double Mutation Diminish Aβ40 Aggregation in Alzheimer's Disease: Key Insights from Molecular Dynamics Simulations
Published in Biophysical journal (07-02-2020)Get full text
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13
Targeting Human Islet Amyloid Polypeptide Aggregation and Toxicity in Type 2 Diabetes: An Overview of Peptide-Based Inhibitors
Published in Chemical research in toxicology (16-11-2020)“…Type 2 diabetes (T2D) is a chronic metabolic disease characterized by insulin resistance and a progressive loss of pancreatic islet β-cell mass, which leads to…”
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14
Overtaking Between Ion Acoustic Multisolitons in an Ion-Beam Plasma
Published in IEEE transactions on plasma science (01-07-2024)“…In this investigation, the propagation characteristics and interaction of ion acoustic multisolitons in an unmagnetized plasma composed of fluid positive ions,…”
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15
Strategizing biodegradable polymeric nanoparticles to cross the biological barriers for cancer targeting
Published in International journal of pharmaceutics (30-06-2019)“…[Display omitted] The biological barriers in the body have been fabricated by nature to protect the body from foreign molecules. The successful delivery of…”
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16
Periodic Inertial Alfvén Waves and Overtaking Between Multisolitons in an Electron-Depleted Dusty Plasma
Published in IEEE transactions on plasma science (01-07-2024)“…The evolution of periodic dust inertial Alfvén (DInA) waves in an electron-depleted dusty plasma has been presented in two fluids plasma consisting of…”
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17
Electron Acoustic Shocks in an Electron Beam Plasma
Published in IEEE transactions on plasma science (01-07-2024)“…Nonlinear analysis for the electron acoustic waves (EAWs) is examined in a multicomponent plasma composed of an electron beam, inertial cold electron,…”
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18
Higher Order Corrections to Kinetic Alfvén Waves in Nonthermal Plasma
Published in IEEE transactions on plasma science (01-07-2024)“…In this investigation, the formation of kinetic Alfvén (KA) solitons in nonthermal electron-positron-ion (e-p-i) plasma has been illustrated. The Korteweg-de…”
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19
Higher-order shock wave structures and phase plane analysis in multicomponent dusty plasma
Published in Europhysics letters (01-03-2023)“…In this investigation, dust acoustic (DA) shocks and dressed shocks formed due to the contribution of higher-order effects in a non-Maxwellian plasma have been…”
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20
Molecular insights into Aβ42 protofibril destabilization with a fluorinated compound D744: A molecular dynamics simulation study
Published in Journal of molecular recognition (01-12-2017)“…The aggregation of amyloid β‐peptide (Aβ42) into toxic oligomers, fibrils, has been identified as a key process in Alzheimer's disease (AD) progression. The…”
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