Search Results - "Kaun, Karla R."

Competing dopamine neurons drive oviposition choice for ethanol in Drosophila by Azanchi, Reza, Kaun, Karla R., Heberlein, Ulrike

“…The neural circuits that mediate behavioral choice evaluate and integrate information from the environment with internal demands and then initiate a behavioral…”
Get full text

A Subset of Serotonergic Neurons Evokes Hunger in Adult Drosophila by Albin, Stephanie D., Kaun, Karla R., Knapp, Jon-Michael, Chung, Phuong, Heberlein, Ulrike, Simpson, Julie H.

“…Hunger is a complex motivational state that drives multiple behaviors. The sensation of hunger is caused by an imbalance between energy intake and expenditure…”
Get full text

Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila by Aso, Yoshinori, Sitaraman, Divya, Ichinose, Toshiharu, Kaun, Karla R, Vogt, Katrin, Belliart-Guérin, Ghislain, Plaçais, Pierre-Yves, Robie, Alice A, Yamagata, Nobuhiro, Schnaitmann, Christopher, Rowell, William J, Johnston, Rebecca M, Ngo, Teri-T B, Chen, Nan, Korff, Wyatt, Nitabach, Michael N, Heberlein, Ulrike, Preat, Thomas, Branson, Kristin M, Tanimoto, Hiromu, Rubin, Gerald M

“…Animals discriminate stimuli, learn their predictive value and use this knowledge to modify their behavior. In Drosophila, the mushroom body (MB) plays a key…”
Get full text

Alcohol Activates Scabrous-Notch to Influence Associated Memories by Petruccelli, Emily, Feyder, Michael, Ledru, Nicolas, Jaques, Yanabah, Anderson, Edward, Kaun, Karla R.

“…Drugs of abuse, like alcohol, modulate gene expression in reward circuits and consequently alter behavior. However, the in vivo cellular mechanisms through…”
Get full text

Automated real-time quantification of group locomotor activity in Drosophila melanogaster by Scaplen, Kristin M., Mei, Nicholas J., Bounds, Hayley A., Song, Sophia L., Azanchi, Reza, Kaun, Karla R.

“…Recent advances in neurogenetics have highlighted Drosophila melanogaste r as an exciting model to study neural circuit dynamics and complex behavior…”
Get full text

Transsynaptic mapping of Drosophila mushroom body output neurons by Scaplen, Kristin M, Talay, Mustafa, Fisher, John D, Cohn, Raphael, Sorkaç, Altar, Aso, Yoshi, Barnea, Gilad, Kaun, Karla R

“…The mushroom body (MB) is a well-characterized associative memory structure within the brain. Analyzing MB connectivity using multiple approaches is critical…”
Get full text

Circuits that encode and guide alcohol-associated preference by Scaplen, Kristin M, Talay, Mustafa, Nunez, Kavin M, Salamon, Sarah, Waterman, Amanda G, Gang, Sydney, Song, Sophia L, Barnea, Gilad, Kaun, Karla R

“…A powerful feature of adaptive memory is its inherent flexibility. Alcohol and other addictive substances can remold neural circuits important for memory to…”
Get full text

Sir2/Sirt1 Links Acute Inebriation to Presynaptic Changes and the Development of Alcohol Tolerance, Preference, and Reward by Engel, Gregory L, Marella, Sunanda, Kaun, Karla R, Wu, Julia, Adhikari, Pratik, Kong, Eric C, Wolf, Fred W

“…Acute ethanol inebriation causes neuroadaptive changes in behavior that favor increased intake. Ethanol-induced alterations in gene expression, through…”
Get full text

Cue-Induced Ethanol Seeking in Drosophila melanogaster Is Dose-Dependent by Nunez, Kavin M, Azanchi, Reza, Kaun, Karla R

“…Alcohol use disorder generates devastating social, medical and economic burdens, making it a major global health issue. The persistent nature of memories…”
Get full text

EGFR and FGFR pathways have distinct roles in Drosophila mushroom body development and ethanol-induced behavior by King, Ian F G, Eddison, Mark, Kaun, Karla R, Heberlein, Ulrike

“…Epidermal Growth Factor Receptor (EGFR) signaling has a conserved role in ethanol-induced behavior in flies and mice, affecting ethanol-induced sedation in…”
Get full text

Natural variation in plasticity of glucose homeostasis and food intake by Kaun, Karla R, Chakaborty-Chatterjee, Munmun, Sokolowski, Marla B

“…Balancing the acquisition, allocation and storage of energy during periods of food deprivation is critical for survival. We show that natural variation in the…”
Get full text

The small GTPase Rheb affects central brain neuronal morphology and memory formation in Drosophila by Brown, Heather L D, Kaun, Karla R, Edgar, Bruce A

“…Mutations in either of two tumor suppressor genes, TSC1 or TSC2, cause tuberous sclerosis complex (TSC), a syndrome resulting in benign hamartomatous tumors…”
Get full text

Alcohol, neuronal plasticity, and mitochondrial trafficking by Hernandez, John, Kaun, Karla R

Get full text

What do the mushroom bodies do for the insect brain? Twenty-five years of progress by Fiala, André, Kaun, Karla R

“…In 1998, a special edition of was published with a discrete focus of synthesizing the state of the field to provide an overview of the function of the insect…”
Get full text

cGMP-dependent protein kinase: linking foraging to energy homeostasis by Kaun, Karla R, Sokolowski, Marla B

“…Successful foraging is necessary for procurement of nutritional resources essential for an animal's survival. Maintenance of foraging and food acquisition is…”
Get more information

Dopaminergic rules of engagement for memory in Drosophila by Kaun, Karla R, Rothenfluh, Adrian

“…Graphical abstract…”
Get full text

Dopamine determines how reward overrides risk by Scaplen, Kristin M., Kaun, Karla R.

“…Why do animals pursue reward in the face of punishment? Dopamine-releasing neurons that promote reward-seeking behaviour indirectly impair those that encode…”
Get full text

Alcohol Causes Lasting Differential Transcription in Drosophila Mushroom Body Neurons by Petruccelli, Emily, Brown, Tariq, Waterman, Amanda, Ledru, Nicolas, Kaun, Karla R

“…Abstract Cues associated with intoxication can elicit cravings for alcohol, leading to increased consumption and relapse in people recovering from alcohol use…”
Get full text

Insights from intoxicated Drosophila by Petruccelli, Emily, Kaun, Karla R.

“…Our understanding of alcohol use disorder (AUD), particularly alcohol's effects on the nervous system, has unquestionably benefited from the use of model…”
Get full text

A Drosophila model for alcohol reward by Kaun, Karla R, Heberlein, Ulrike, Azanchi, Reza, Maung, Zaw, Hirsh, Jay

“…This study presents a new assay for investigating alcohol reward in Drosophila . Flies learned to associate cues with ethanol intoxication and developed a…”
Get full text