Search Results - "Kaulich, K."

EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance by Depner, C., zum Buttel, H., Böğürcü, N., Cuesta, A. M., Aburto, M. R., Seidel, S., Finkelmeier, F., Foss, F., Hofmann, J., Kaulich, K., Barbus, S., Segarra, M., Reifenberger, G., Garvalov, B. K., Acker, T., Acker-Palmer, A.

“…Diffuse invasion of the surrounding brain parenchyma is a major obstacle in the treatment of gliomas with various therapeutics, including anti-angiogenic…”
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Longitudinal stability of molecular alterations and drug response profiles in tumor spheroid cell lines enables reproducible analyses by Nickel, A.C., Picard, D., Qin, N., Wolter, M., Kaulich, K., Hewera, M., Pauck, D., Marquardt, V., Torga, G., Muhammad, S., Zhang, W., Schnell, O., Steiger, H.-J., Hänggi, D., Fritsche, E., Her, N.-G., Nam, D.-H., Carro, M.S., Remke, M., Reifenberger, G., Kahlert, U.D.

“…The utility of patient-derived tumor cell lines as experimental models for glioblastoma has been challenged by limited representation of the in vivo tumor…”
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Multicenter validation of cancer gene panel-based next-generation sequencing for translational research and molecular diagnostics by Hirsch, B., Endris, V., Lassmann, S., Weichert, W., Pfarr, N., Schirmacher, P., Kovaleva, V., Werner, M., Bonzheim, I., Fend, F., Sperveslage, J., Kaulich, K., Zacher, A., Reifenberger, G., Köhrer, K., Stepanow, S., Lerke, S., Mayr, T., Aust, D. E., Baretton, G., Weidner, S., Jung, A., Kirchner, T., Hansmann, M. L., Burbat, L., von der Wall, E., Dietel, M., Hummel, M.

“…The simultaneous detection of multiple somatic mutations in the context of molecular diagnostics of cancer is frequently performed by means of amplicon-based…”
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Frequent loss of chromosome 9, homozygous CDKN2A/p14(ARF)/CDKN2B deletion and low TSC1 mRNA expression in pleomorphic xanthoastrocytomas by Weber, R G, Hoischen, A, Ehrler, M, Zipper, P, Kaulich, K, Blaschke, B, Becker, A J, Weber-Mangal, S, Jauch, A, Radlwimmer, B, Schramm, J, Wiestler, O D, Lichter, P, Reifenberger, G

“…The molecular pathogenesis of pleomorphic xanthoastrocytoma (PXA), a rare astrocytic brain tumor with a relatively favorable prognosis, is still poorly…”
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Frequent loss of chromosome 9, homozygous CDKN2A/p14ARF/CDKN2B deletion and low TSC1 mRNA expression in pleomorphic xanthoastrocytomas by WEBER, R. G, HOISCHEN, A, SCHRAMM, J, WIESTLER, O. D, LICHTER, P, REIFENBERGER, G, EHRLER, M, ZIPPER, P, KAULICH, K, BLASCHKE, B, BECKER, A. J, WEBER-MANGAL, S, JAUCH, A, RADLWIMMER, B

“…The molecular pathogenesis of pleomorphic xanthoastrocytoma (PXA), a rare astrocytic brain tumor with a relatively favorable prognosis, is still poorly…”
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P04.21 MOLECULAR DIAGNOSTICS OF MALIGNANT GLIOMAS USING NEXT-GENERATION GENE PANEL SEQUENCING by Veiser, A., Kaulich, K., Stepanow, S., Wolter, M., Kohrer, K., Reifenberger, G.

“…Gliomas are histologically classified according to the World Health Organization (WHO) classification of central nervous system tumors into distinct tumor…”
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Expression of the CD34 antigen in pleomorphic xanthoastrocytomas by REIFENBERGER, G, KAULICH, K, WIESTLER, O. D, BLÜMCKE, I

“…Pleomorphic xanthoastrocytoma (PXA) is a rare, superficially located astrocytic glioma of children and young adults, which is associated with a relatively…”
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Lipoastrocytoma: a rare low-grade astrocytoma variant of pediatric age by GIANGASPERO, F, KAULICH, K, CENACCHI, G, CERASOLI, S, LERCH, K.-D, BREU, H, REUTER, T, REIFENBERGER, G

“…We report on two children with cerebral gliomas showing extensive lipomatous change of tumor cells. One tumor was a large mass occupying the temporal and…”
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Mosaic structure of the cox2 gene in the petite negative yeast Schizosaccharomyces pombe: a group II intron is inserted at the same location as the otherwise unrelated group II introns in the mitochondria of higher plants by Schäfer, B, Kaulich, K, Wolf, K

“…In contrast to homologous genes in other fungal mitochondrial genomes, the gene encoding subunit 2 of cytochrome oxidase ( cox2) in several Schizosaccharomyces…”
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Genome-wide methylation profiling of glioblastoma cell-derived extracellular vesicle DNA allows tumor classification by Maire, Cecile L, Fuh, Marceline M, Kaulich, Kerstin, Fita, Krystian D, Stevic, Ines, Heiland, Dieter H, Welsh, Joshua A, Jones, Jennifer C, Görgens, André, Ricklefs, Tammo, Dührsen, Lasse, Sauvigny, Thomas, Joosse, Simon A, Reifenberger, Guido, Pantel, Klaus, Glatzel, Markus, Miklosi, Andras G, Felce, James H, Caselli, Marco, Pereno, Valerio, Reimer, Rudolph, Schlüter, Hartmut, Westphal, Manfred, Schüller, Ulrich, Lamszus, Katrin, Ricklefs, Franz L

“…Abstract Background Genome-wide DNA methylation profiling has recently been developed into a tool that allows tumor classification in central nervous system…”
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P10.07.A A CLINICALLY COMPATIBLE IN VITRO DRUG-SCREENING PLATFORM IDENTIFIES THERAPEUTIC VULNERABILITIES IN PRIMARY CULTURES OF BRAIN METASTASES by Jeising, S, Trübel, J, Felsberg, J, Picard, D, Wolter, M, Kaulich, K, Häberle, L, Esposito, I, Steinmann, J, Cornelius, J, Beez, T, Rapp, M, Sabel, M, Nickel, A, Remke, M, Reifenberger, G, Qin, N

“…Abstract BACKGROUND Approximately 20% of cancer patients (including lung, melanoma, breast, renal, and colorectal cancer patients) develop brain metastases…”
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P11.45 Synergistic growth inhibition mediated by dual PI3K/mTOR pathway targeting and genetic or direct pharmacological AKT inhibition in human glioblastoma models by von Achenbach, C, Weller, M, Kaulich, K, Gramatzki, D, Zacher, A, Fabbro, D, Reifenberger, G, Szabó, E

“…Abstract BACKGROUND Molecular genetic aberrations in the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway…”
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P04.21MOLECULAR DIAGNOSTICS OF MALIGNANT GLIOMAS USING NEXT-GENERATION GENE PANEL SEQUENCING by Veiser, A., Kaulich, K., Stepanow, S., Wolter, M., Köhrer, K., Reifenberger, G.

“…Gliomas are histologically classified according to the World Health Organization (WHO) classification of central nervous system tumors into distinct tumor…”
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P10.07.A A CLINICALLY COMPATIBLEIN VITRODRUG-SCREENING PLATFORM IDENTIFIES THERAPEUTIC VULNERABILITIES IN PRIMARY CULTURES OF BRAIN METASTASES by Jeising, S, Trübel, J, Felsberg, J, Picard, D, Wolter, M, Kaulich, K, Häberle, L, Esposito, I, Steinmann, J, Cornelius, J, Beez, T, Rapp, M, Sabel, M, Nickel, A, Remke, M, Reifenberger, G, Qin, N

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AI-28 RECURRENT GLIOBLASTOMAS AFTER TREATMENT WITH BEVACIZUMAB by Tabatabai, G., Felsberg, J., Sabel, M., Kaulich, K., Hofer, S., Westphal, M., Weller, M., Reifenberger, G.

“…Bevacizumab, a humanized monoclonal antibody to vascular endothelial growth factor, has been evaluated in the treatment of patients with primary or recurrent…”
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MOLECULAR GENETIC DETERMINANTS OF LONG-TERM SURVIVAL WITH GLIOBLASTOMA by Weller, M., Weber, R. G., Riehmer, V., Kaulich, K., Willscher, E., Wirth, H., Gietzelt, J., Hentschel, B., Westphal, M., Simon, M., Schackert, G., Schramm, J., Matschke, J., Sabel, M. C., Gramatzki, D., Felsberg, J., Hartmann, C., Steinbach, J. P., Schlegel, U., Wick, W., Radlwimmer, B., Pietsch, T., Tonn, J. C., von Deimling, A., Binder, H., Loeffler, M., Reifenberger, G.

“…BACKGROUND: The prognosis of glioblastoma, the most malignant type of glioma, is still poor, with only a minority of patients showing long-term survival of…”
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PROGNOSTIC SIGNIFICANCE OF CLINICAL, HISTOPATHOLOGICAL, AND MOLECULAR CHARACTERISTICS OF MEDULLOBLASTOMAS IN THE PROSPECTIVE HIT2000 MULTICENTER CLINICAL TRIAL COHORT by Pietsch, T., Schmidt, R., Remke, M., Korshunov, A., Hovestadt, V., Jones, D. T., Felsberg, J., Kaulich, K., Goschzik, T., Kool, M., Northcott, P. A., von Hoff, K., von Bueren, A. O., Friedrich, C., Skladny, H., Fleischhack, G., Taylor, M. D., Cremer, F., Lichter, P., Faldum, A., Reifenberger, G., Rutkowski, S., Pfister, S. M.

“…BACKGROUND: This study aimed to prospectively evaluate clinical, histopathological and molecular variables for outcome prediction in medulloblastoma patients…”
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Liver function indicators in patients with breast cancer before and after detection of hepatic metastases-a retrospective study by Leser, Carmen, Dorffner, Georg, Marhold, Maximilian, Rutter, Anemone, Döger, Mert, Singer, Christian, König-Castillo, Deirdre Maria, Deutschmann, Christine, Holzer, Iris, König-Castillo, Daniel, Gschwantler-Kaulich, Daphne

“…Liver metastases are common in patients with breast cancer, and determining the factors associated with such metastases may improve both their early detection…”
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Genetic Alterations Commonly Found in Diffusely Infiltrating Cerebral Gliomas Are Rare or Absent in Pleomorphic Xanthoastrocytomas by KAULICH, KERSTIN, BLASCHKE, BRITTA, NÜMANN, ASTRID, DEIMLING, ANDREAS VON, WIESTLER, OTMAR D, WEBER, RUTHILD G, REIFENBERGER, GUIDO

“…Pleomorphic xanthoastrocytoma (PXA) is a rare, usually well-circumscribed and superficially located neoplasm that preferentially arises in the cerebral cortex…”
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Frequent loss of chromosome 9, homozygous CDKN2A/p14 super(ARF)/CDKN2B deletion and low TSC1 mRNA expression in pleomorphic xanthoastrocytomas by Weber, R G, Hoischen, A, Ehrler, M, Zipper, P, Kaulich, K, Blaschke, B, Becker, A J, Weber-Mangal, S, Jauch, A, Radlwimmer, B, Schramm, J, Wiestler, O D, Lichter, P, Reifenberger, G

“…The molecular pathogenesis of pleomorphic xanthoastrocytoma (PXA), a rare astrocytic brain tumor with a relatively favorable prognosis, is still poorly…”
Get full text