Search Results - "Kaul, Dhananjay K."

Sickle cell biomechanics by Barabino, Gilda A, Platt, Manu O, Kaul, Dhananjay K

“…As the predominant cell type in blood, red blood cells (RBCs) and their biomechanical properties largely determine the rheological and hemodynamic behavior of…”
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Sickle Red Cell-Endothelium Interactions by Kaul, Dhananjay K., Finnegan, Eileen, Barabino, Gilda A.

“…Periodic recurrence of painful vaso-occlusive crisis is the defining feature of sickle cell disease. Among multiple pathologies associated with this disease,…”
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Arginine therapy of transgenic-knockout sickle mice improves microvascular function by reducing non-nitric oxide vasodilators, hemolysis, and oxidative stress by Kaul, Dhananjay K, Zhang, Xiaoqin, Dasgupta, Trisha, Fabry, Mary E

“…In sickle cell disease, nitric oxide (NO) depletion by cell-free plasma hemoglobin and/or oxygen radicals is associated with arginine deficiency, impaired NO…”
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Protective effect of arginine on oxidative stress in transgenic sickle mouse models by Dasgupta, Trisha, Hebbel, Robert P., Kaul, Dhananjay K.

“…Sickle cell disease (SCD) is characterized by reperfusion injury and chronic oxidative stress. Oxidative stress and hemolysis in SCD result in inactivation of…”
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Antisickling property of fetal hemoglobin enhances nitric oxide bioavailability and ameliorates organ oxidative stress in transgenic-knockout sickle mice by Dasgupta, Trisha, Fabry, Mary E, Kaul, Dhananjay K

“…In sickle cell disease (SCD), the events originating from hemoglobin S polymerization and intravascular sickling lead to reperfusion injury, hemolysis,…”
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Antisickling fetal hemoglobin reduces hypoxia-inducible factor-1α expression in normoxic sickle mice: microvascular implications by Kaul, Dhananjay K, Fabry, Mary E, Suzuka, Sandra M, Zhang, Xiaoqin

“…Chronic inflammation is a salient feature of sickle cell disease (SCD) and transgenic-knockout sickle (BERK) mice. Inflammation is implicated in the activation…”
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RBC Adhesion to Vascular Endothelial Cells: More Potent than RBC Aggregation in Inducing Circulatory Disorders by Yedgar, Saul, Kaul, Dhananjay K., Barshtein, Gregory

“…Growing evidence has suggested that the adhesion of red blood cells (RBCs) to blood vessel wall endothelial cells (ECs) is a potent catalyst of…”
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Effect of fetal hemoglobin on microvascular regulation in sickle transgenic-knockout mice by Kaul, Dhananjay K, Liu, Xiao-du, Chang, Hee-Yoon, Nagel, Ronald L, Fabry, Mary E

“…In sickle cell disease, intravascular sickling and attendant flow abnormalities underlie the chronic inflammation and vascular endothelial abnormalities…”
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Anti-inflammatory therapy ameliorates leukocyte adhesion and microvascular flow abnormalities in transgenic sickle mice by Kaul, Dhananjay K, Liu, Xiao-Du, Choong, Stephana, Belcher, John D, Vercellotti, Gregory M, Hebbel, Robert P

“…In sickle cell disease, inflammatory activation of vascular endothelium and increased leukocyte-endothelium interaction may play an important role in the…”
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Small-molecule cyclic alpha V beta 3 antagonists inhibit sickle red cell adhesion to vascular endothelium and vasoocclusion by Finnegan, Eileen M, Barabino, Gilda A, Liu, Xiao-du, Chang, Hee-Yoon, Jonczyk, Alfred, Kaul, Dhananjay K

“…Abnormal adhesion of sickle red blood cells (SS RBCs) to vascular endothelium may play an important role in vasoocclusion in sickle cell disease. Accruing…”
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Inhibition of sickle red cell adhesion and vasoocclusion in the microcirculation by antioxidants by Kaul, Dhananjay K, Liu, Xiao-du, Zhang, Xiaoqin, Ma, Li, Hsia, Carleton J C, Nagel, Ronald L

“…In sickle cell anemia (SCA), inflammatory (i.e., intravascular sickling and transient vasoocclusive) events result in chronic endothelial activation. In…”
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In Vivo Studies of Sickle Red Blood Cells by KAUL, DHANANJAY K., FABRY, MARY E.

“…The defining clinical feature of sickle cell anemia is periodic occurrence of painful vasoocclusive crisis. Factors that promote trapping and sickling of red…”
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A transgenic mouse model expressing exclusively human hemoglobin E: Indications of a mild oxidative stress by Chen, Qiuying, Fabry, Mary E., Rybicki, Anne C., Suzuka, Sandra M., Balazs, Tatiana C., Etzion, Zipora, de Jong, Kitty, Akoto, Edna K., Canterino, Joseph E., Kaul, Dhananjay K., Kuypers, Frans A., Lefer, David, Bouhassira, Eric E., Hirsch, Rhoda Elison

“…Hemoglobin (Hb) E (β26 Glu→Lys) is the most common abnormal hemoglobin (Hb) variant in the world. Homozygotes for HbE are mildly thalassemic as a result of the…”
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Robust Vascular Protective Effect of Hydroxamic Acid Derivatives in a Sickle Mouse Model of Inflammation by Kaul, Dhananjay K., Kollander, Rahn, Mahaseth, Hemchandra, Liu, Xiao-Du, Solovey, Anna, Belcher, John, Kelm, Robert J., Vercellotti, Gregory M., Hebbel, Robert P.

“…Objective: Clinically, the vascular pathobiology of human sickle cell disease includes an abnormal state of chronic inflammation and activation of the…”
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Quels sont les effets pathologiques de la drépanocytose sur la biologie vasculaire ? by KAUL, Dhananjay K

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Ameliorating effects of fluorocarbon emulsion on sickle red blood cell–induced obstruction in an ex vivo vasculature by Kaul, Dhananjay K., Liu, Xiao-du, Nagel, Ronald L.

“…In sickle cell (SS) vaso-occlusion, the culminating event is blockage of blood vessels by sickled red blood cells (SS RBCs). As shown in animal models, SS…”
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Differential gene expression in the kidney of sickle cell transgenic mice: upregulated genes by Rybicki, Anne C, Fabry, Mary E, Does, Mark D, Kaul, Dhananjay K, Nagel, Ronald L

“…The S+S-Antilles transgenic mouse used in this study has renal defects similar to those seen in sickle cell anemia patients: congested glomeruli, medullary…”
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Sickle mouse red cells activate endothelium by heme‐mediated peroxide generation and promote red cell and leukocyte adhesion by Kaul, Dhananjay K., Shah, Janki, Suzuka, Sandra, Fabry, Mary E.

“…Abstract only Sickle red blood cells (SS RBCs) are known to generate reactive oxygen species due to autoxidation of hemoglobin S (HbS). We hypothesize that HbS…”
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Protective Effect of Fetal Hemoglobin On Inflammation-Induced Expression of Hypoxia-Inducible Factor-1α (HIF-1α) in Sickle Mice: Microvascular Implications by Kaul, Dhananjay K., Fabry, Mary E., Suzuka, Sandra M, Shah, Janki

“…Abstract 3250 Chronic inflammation is a salient feature of human sickle cell disease (SCD) and transgenic-knockout sickle (BERK) mouse model. Although tissue…”
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Anti-Interleukin-1β Antibody-Based Therapy Ameliorates Endothelial Activation and Inflammation in Sickle Mice by Kaul, Dhananjay K., Thangaswamy, Sangeetha, Suzuka, Sandra M., Fabry, Mary E., Wanderer, Alan A., Gram, Hermann

“…Abstract 848 Inflammation is a recognized feature of sickle cell disease (SCD). Reperfusion injury (caused by vaso-occlusive events) and elevated levels of…”
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