Search Results - "Kaufmann, William K."

Control of skin cancer by the circadian rhythm by Gaddameedhi, Shobhan, Selby, Christopher P, Kaufmann, William K, Smart, Robert C, Sancar, Aziz

“…Skin cancer is the most common form of cancer in the United States. The main cause of this cancer is DNA damage induced by the UV component of sunlight. In…”
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The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts by Saini, Natalie, Roberts, Steven A, Klimczak, Leszek J, Chan, Kin, Grimm, Sara A, Dai, Shuangshuang, Fargo, David C, Boyer, Jayne C, Kaufmann, William K, Taylor, Jack A, Lee, Eunjung, Cortes-Ciriano, Isidro, Park, Peter J, Schurman, Shepherd H, Malc, Ewa P, Mieczkowski, Piotr A, Gordenin, Dmitry A

“…Accumulation of somatic changes, due to environmental and endogenous lesions, in the human genome is associated with aging and cancer. Understanding the…”
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The Human Tim/Tipin Complex Coordinates an Intra-S Checkpoint Response to UV That Slows Replication Fork Displacement by Unsal-Kaçmaz, Keziban, Chastain, Paul D, Qu, Ping-Ping, Minoo, Parviz, Cordeiro-Stone, Marila, Sancar, Aziz, Kaufmann, William K

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Chloroquine Promotes Apoptosis in Melanoma Cells by Inhibiting BH3 Domain–Mediated PUMA Degradation by Lakhter, Alexander J., Sahu, Ravi P., Sun, Yang, Kaufmann, William K., Androphy, Elliot J., Travers, Jeffrey B., Naidu, Samisubbu R.

“…The Bcl homology-3 (BH3)-only protein p53 upregulated modulator of apoptosis (PUMA) counters Bcl-2 family anti-apoptotic proteins and promotes apoptosis…”
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Coupling of Human Circadian and Cell Cycles by the Timeless Protein by Ünsal-Kaçmaz, Keziban, Mullen, Thomas E., Kaufmann, William K., Sancar, Aziz

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Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress by Kemp, Michael G., Akan, Zafer, Yilmaz, Seçil, Grillo, Mary, Smith-Roe, Stephanie L., Kang, Tae-Hong, Cordeiro-Stone, Marila, Kaufmann, William K., Abraham, Robert T., Sancar, Aziz, Ünsal-Kaçmaz, Keziban

“…Mammalian Timeless is a multifunctional protein that performs essential roles in the circadian clock, chromosome cohesion, DNA replication fork protection, and…”
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What's going on at stalled forks? by Kaufmann, William K.

“…Comment on: Trego KS, et al. Cell Cycle 2011; 10:1998-2007…”
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Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells by Bower, Jacquelyn J., Vance, Leah D., Psioda, Matthew, Smith-Roe, Stephanie L., Simpson, Dennis A., Ibrahim, Joseph G., Hoadley, Katherine A., Perou, Charles M., Kaufmann, William K.

“…Genomic instability is a hallmark of breast cancer, contributes to tumor heterogeneity, and influences chemotherapy resistance. Although Gap 2 and mitotic…”
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Extracting gene expression patterns and identifying co-expressed genes from microarray data reveals biologically responsive processes by Chou, Jeff W, Zhou, Tong, Kaufmann, William K, Paules, Richard S, Bushel, Pierre R

“…A common observation in the analysis of gene expression data is that many genes display similarity in their expression patterns and therefore appear to be…”
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An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage by Heffernan, Timothy P., Simpson, Dennis A., Frank, Alexandra R., Heinloth, Alexandra N., Paules, Richard S., Cordeiro-Stone, Marila, Kaufmann, William K.

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Cell-type-specific responses to chemotherapeutics in breast cancer by TROESTER, Melissa A, HOADLEY, Katherine A, SØRLIE, Therese, HERBERT, Brittney-Shea, BØRRESEN-DALE, Anne-Lise, LØNNING, Per Eystein, SHAY, Jerry W, KAUFMANN, William K, PEROU, Charles M

“…Recent microarray studies have identified distinct subtypes of breast tumors that arise from different cell types and that show statistically significant…”
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Timeless functions independently of the Tim-Tipin complex to promote sister chromatid cohesion in normal human fibroblasts by Smith-Roe, Stephanie L., Patel, Shivani S., Simpson, Dennis A., Zhou, Ying Chun, Rao, Shangbang, Ibrahim, Joseph G., Kaiser-Rogers, Kathleen A., Cordeiro-Stone, Marila, Kaufmann, William K.

“…The Timeless-Tipin complex and Claspin are mediators of the ATR-dependent activation of Chk1 in the intra-S checkpoint response to stalled DNA replication…”
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Cdc7-Dbf4 and the Human S Checkpoint Response to UVC by Heffernan, Timothy P., Ünsal-Kaçmaz, Keziban, Heinloth, Alexandra N., Simpson, Dennis A., Paules, Richard S., Sancar, Aziz, Cordeiro-Stone, Marila, Kaufmann, William K.

“…The S checkpoint response to ultraviolet radiation (UVC) that inhibits replicon initiation is dependent on the ATR and Chk1 kinases. Downstream effectors of…”
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Revised genetic requirements for the decatenation G2 checkpoint: The role of ATM by Bower, Jacquelyn J., Zhou, Yingchun, Zhou, Tong, Simpson, Dennis A., Arlander, Sonnet J., Paules, Richard S., Cordeiro-Stone, Marila, Kaufmann, William K.

“…The decatenation G2 checkpoint is proposed to delay cellular progression from G2 into mitosis when intertwined daughter chromatids are insufficiently…”
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Human papilloma virus type16 E6 deregulates CHK1 and sensitizes human fibroblasts to environmental carcinogens independently of its effect on p53 by Chen, Bo, Simpson, Dennis A., Zhou, Yingchun, Mitra, Amritava, Mitchell, David L., Cordeiro-Stone, Marila, Kaufmann, William K.

“…After treatment with ultraviolet radiation (UV), human fibroblasts that express the HPV type 16 E6 oncoprotein display defects in repair of cyclobutane…”
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The human intra-S checkpoint response to UVC-induced DNA damage by KAUFMANN, William K

“…The intra-S checkpoint response to 254 nm light (UVC)-induced DNA damage appears to have dual functions to slow the rate of DNA synthesis and stabilize…”
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Checkpoint Regulation of Replication Dynamics in UV-Irradiated Human Cells by Chastain II, Paul D., Heffernan, Timothy P., Nevis, Kathleen, Lin, Li, Kaufmann, William K., Kaufman, David G., Cordeiro-Stone, Marila

“…At any moment during S phase, regions of genomic DNA are in various stages of replication (i.e. initiation, chain elongation, and termination). These stages…”
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A mathematical model for human nucleotide excision repair: Damage recognition by random order assembly and kinetic proofreading by Kesseler, Kevin J., Kaufmann, William K., Reardon, Joyce T., Elston, Timothy C., Sancar, Aziz

“…A mathematical model of human nucleotide excision repair was constructed and validated. The model incorporates cooperative damage recognition by RPA, XPA, and…”
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A bright Quantum of Time in the Cleaver Laboratory; a Tribute and Retrospective by Kaufmann, William K.

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Melanoma cells show a heterogeneous range of sensitivity to ionizing radiation and are radiosensitized by inhibition of B-RAF with PLX-4032 by Sambade, Maria J, Peters, Eldon C, Thomas, Nancy E, Kaufmann, William K, Kimple, Randall J, Shields, Janiel M

“…Abstract Purpose To assess the relative radiosensitivities of a large collection of melanoma cell lines and to determine whether pharmacologic inhibition of…”
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