Search Results - "Kaufmann, Martin"

Cytochrome P450-mediated metabolism of vitamin D by Jones, Glenville, Prosser, David E., Kaufmann, Martin

“…The vitamin D signal transduction system involves a series of cytochrome P450-containing sterol hydroxylases to generate and degrade the active hormone,…”
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CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo by Zhu, Jinge G., Ochalek, Justin T., Kaufmann, Martin, Jones, Glenville, DeLuca, Hector F.

“…Bioactivation of vitamin D consists of two sequential hydroxylation steps to produce 1α,25-dihydroxyvitamin D ₃. It is clear that the second or…”
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Diagnostic Aspects of Vitamin D: Clinical Utility of Vitamin D Metabolite Profiling by Jones, Glenville, Kaufmann, Martin

“…The assay of vitamin D that began in the 1970s with the quantification of one or two metabolites, 25‐OH‐D or 1,25‐(OH)2D, continues to evolve with the…”
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A kidney-specific genetic control module in mice governs endocrine regulation of the cytochrome P450 gene Cyp27b1 essential for vitamin D3 activation by Meyer, Mark B., Benkusky, Nancy A., Kaufmann, Martin, Lee, Seong Min, Onal, Melda, Jones, Glenville, Pike, J. Wesley

“…The vitamin D endocrine system regulates mineral homeostasis through its activities in the intestine, kidney, and bone. Terminal activation of vitamin D3 to…”
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Autosomal-Recessive Mutations in SLC34A1 Encoding Sodium-Phosphate Cotransporter 2A Cause Idiopathic Infantile Hypercalcemia by Schlingmann, Karl P, Ruminska, Justyna, Kaufmann, Martin, Dursun, Ismail, Patti, Monica, Kranz, Birgitta, Pronicka, Ewa, Ciara, Elzbieta, Akcay, Teoman, Bulus, Derya, Cornelissen, Elisabeth A M, Gawlik, Aneta, Sikora, Przemysław, Patzer, Ludwig, Galiano, Matthias, Boyadzhiev, Veselin, Dumic, Miroslav, Vivante, Asaf, Kleta, Robert, Dekel, Benjamin, Levtchenko, Elena, Bindels, René J, Rust, Stephan, Forster, Ian C, Hernando, Nati, Jones, Glenville, Wagner, Carsten A, Konrad, Martin

“…Idiopathic infantile hypercalcemia (IIH) is characterized by severe hypercalcemia with failure to thrive, vomiting, dehydration, and nephrocalcinosis…”
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A chromatin-based mechanism controls differential regulation of the cytochrome P450 gene Cyp24a1 in renal and non-renal tissues by Meyer, Mark B., Lee, Seong Min, Carlson, Alex H., Benkusky, Nancy A., Kaufmann, Martin, Jones, Glenville, Pike, J. Wesley

“…Cytochrome P450 family 27 subfamily B member 1 (CYP27B1) and CYP24A1 function to maintain physiological levels of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in the…”
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Randomized trial of two doses of vitamin D3 in preterm infants <32 weeks: Dose impact on achieving desired serum 25(OH)D3 in a NICU population by Anderson-Berry, Ann, Thoene, Melissa, Wagner, Julie, Lyden, Elizabeth, Jones, Glenville, Kaufmann, Martin, Van Ormer, Matthew, Hanson, Corrine

“…Recommendations for vitamin D supplementation for preterm infants span a wide range of doses. Response to vitamin D supplementation and impact on outcomes in…”
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Reliable identification of prostate cancer using mass spectrometry metabolomic imaging in needle core biopsies by Morse, Nicole, Jamaspishvili, Tamara, Simon, David, Patel, Palak G., Ren, Kevin Yi Mi, Wang, Jenny, Oleschuk, Richard, Kaufmann, Martin, Gooding, Robert J., Berman, David M.

“…Metabolomic profiling can aid in understanding crucial biological processes in cancer development and progression and can also yield diagnostic biomarkers…”
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Therapeutic platelet transfusion versus routine prophylactic transfusion in patients with haematological malignancies: an open-label, multicentre, randomised study by Wandt, Hannes, Prof, Schaefer-Eckart, Kerstin, MD, Wendelin, Knut, MD, Pilz, Bettina, Wilhelm, Martin, Prof, Thalheimer, Markus, MD, Mahlknecht, Ulrich, Prof, Ho, Anthony, Prof, Schaich, Markus, Prof, Kramer, Michael, MSc, Kaufmann, Martin, MD, Leimer, Lothar, MD, Schwerdtfeger, Rainer, MD, Conradi, Roland, MD, Dölken, Gottfried, Prof, Klenner, Anne, MD, Hänel, Mathias, MD, Herbst, Regina, MD, Junghanss, Christian, Prof, Ehninger, Gerhard, Prof

“…Summary Background Routine prophylactic platelet transfusion is the standard of care for patients with severe thrombocytopenia. We assessed the effect of a new…”
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Improved Screening Test for Idiopathic Infantile Hypercalcemia Confirms Residual Levels of Serum 24,25‐(OH)2D3 in Affected Patients by Kaufmann, Martin, Morse, Nicole, Molloy, Billy Joe, Cooper, Donald P, Schlingmann, Karl Peter, Molin, Arnaud, Kottler, Marie Laure, Gallagher, J Christopher, Armas, Laura, Jones, Glenville

“…ABSTRACT CYP24A1 mutations are now accepted as a cause of idiopathic infantile hypercalcemia (IIH). A rapid liquid‐chromatography tandem mass spectrometry…”
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A High-Calcium and Phosphate Rescue Diet and VDR-Expressing Transgenes Normalize Serum Vitamin D Metabolite Profiles and Renal Cyp27b1 and Cyp24a1 Expression in VDR Null Mice by Kaufmann, Martin, Lee, Seong Min, Pike, J. Wesley, Jones, Glenville

“…Vitamin D receptor (VDR)-mediated 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)-dependent gene expression is compromised in the VDR null mouse. The biological…”
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Differential diagnosis of vitamin D–related hypercalcemia using serum vitamin D metabolite profiling by Kaufmann, Martin, Schlingmann, Karl‐Peter, Berezin, Linor, Molin, Arnaud, Sheftel, Jesse, Vig, Melanie, Gallagher, John C., Nagata, Akiko, Masoud, Shadi Sedghi, Sakamoto, Ryota, Nagasawa, Kazuo, Uesugi, Motonari, Kottler, Marie Laure, Konrad, Martin, Jones, Glenville

“…ABSTRACT Genetic causes of vitamin D–related hypercalcemia are known to involve mutation of 25‐hydroxyvitamin D‐24‐hydroxylase CYP24A1 or the sodium phosphate…”
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Vitamin D and Diseases of Mineral Homeostasis: A Cyp24a1 R396W Humanized Preclinical Model of Infantile Hypercalcemia Type 1 by St-Arnaud, René, Arabian, Alice, Kavame, Dila, Kaufmann, Martin, Jones, Glenville

“…Infantile hypercalcemia type 1 (HCINF1), previously known as idiopathic infantile hypercalcemia, is caused by mutations in the 25-hydroxyvitamin D…”
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Significance of serum 24,25-dihydroxyvitamin D in the assessment of vitamin D status: a double-edged sword? by Cashman, Kevin D, Hayes, Aoife, Galvin, Karen, Merkel, Joyce, Jones, Glenville, Kaufmann, Martin, Hoofnagle, Andrew N, Carter, Graham D, Durazo-Arvizu, Ramon A, Sempos, Christopher T

“…24,25-Dihydroxyvitamin D [24,25(OH)2D] in serum may be both a nuisance and nutritionally valuable. We investigated the impact of 24,25(OH)2D3 on the…”
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An Efficient Calibration System of Optical Interferometer for Measuring Middle and Upper Atmospheric Wind by Zhu, Guangyi, Zhu, Yajun, Kaufmann, Martin, Wang, Tiancai, Liu, Weijun, Xu, Jiyao

“…Detection of the Doppler shift of airglow radiation in the middle and upper atmosphere is one of the most important methods for remote sensing of the…”
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Long-term outcomes and renal responses following autologous hematopoietic stem cell transplantation for light chain deposition disease: a retrospective study on behalf of the Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation by Garderet, Laurent, Gras, Luuk, Koster, Linda, De Wreede, Liesbeth, Montserrat, Rovira, Vincent, Laure, Fenk, Roland, Karunanithi, Kamaraj, Deeren, Dries, Kaufmann, Martin, Kuball, Jürgen, Ozdogu, Hakan, Cascon, Maria Jesus Pascual, Passweg, Jakob, Rye, Adam, Salmenniemi, Urpu, Snowden, John, Hansen, Charlotte Toftmann, Leleu, Xavier, Gastaud, Lauris, Sokolowska, Joanna Drozd, Raj, Kavita, Beksac, Meral, Schönland, Stefan, Hayden, Patrick, McLornan, Donal

“…There is little long-term outcome data on the efficacy of autologous hematopoietic stem cell transplantation (ASCT) in light chain deposition disease (LCDD)…”
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Small-molecule metabolome identifies potential therapeutic targets against COVID-19 by Bennet, Sean, Kaufmann, Martin, Takami, Kaede, Sjaarda, Calvin, Douchant, Katya, Moslinger, Emily, Wong, Henry, Reed, David E., Ellis, Anne K., Vanner, Stephen, Colautti, Robert I., Sheth, Prameet M.

“…Respiratory viruses are transmitted and acquired via the nasal mucosa, and thereby may influence the nasal metabolome composed of biochemical products produced…”
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Randomized phase III GnG study on two schedules of gemtuzumab ozogamicin as adjunct to intensive induction therapy and double-blinded intensive postremission therapy with or without glasdegib in patients with newly diagnosed acute myeloid leukemia by Jaramillo, Sonia, Krisam, Johannes, Le Cornet, Lucian, Kratzmann, Markus, Baumann, Lukas, Eissymont, Olga, Crysandt, Martina, Görner, Martin, Kayser, Sabine, Krause, Stefan, Schliemann, Christoph, Gaska, Tobias, Kaufmann, Martin, Chemnitz, Jens, Schaich, Markus, Hoellein, Alexander, Platzbecker, Uwe, Kieser, Meinhard, Müller-Tidow, Carsten, Schlenk, Richard F

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Sensor-Based Automated Detection of Electrosurgical Cautery States by Ehrlich, Josh, Jamzad, Amoon, Asselin, Mark, Rodgers, Jessica Robin, Kaufmann, Martin, Haidegger, Tamas, Rudan, John, Mousavi, Parvin, Fichtinger, Gabor, Ungi, Tamas

“…In computer-assisted surgery, it is typically required to detect when the tool comes into contact with the patient. In activated electrosurgery, this is known…”
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Stable and Easily Accessible Functional Dyes: Dihydrotetraazaanthracenes as Versatile Precursors for Higher Acenes by Gampe, Dominique Mario, Kaufmann, Martin, Jakobi, Dörthe, Sachse, Torsten, Presselt, Martin, Beckert, Rainer, Görls, Helmar

“…A series of new dihydrotetraazaanthracenes and one new dihydrotetraazatetracene as substances for applications in organoelectronic devices and as suitable…”
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