Search Results - "Kaufmann, B."

Control of Lead Sources in the United States, 1970-2017: Public Health Progress and Current Challenges to Eliminating Lead Exposure by Dignam, Timothy, Kaufmann, Rachel B, LeStourgeon, Lauren, Brown, Mary Jean

“…During the past 45 years, exposure to lead has declined dramatically in the United States. This sustained decline is measured by blood and environmental lead…”
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Gene therapy on the move by Kaufmann, Kerstin B., Büning, Hildegard, Galy, Anne, Schambach, Axel, Grez, Manuel

“…The first gene therapy clinical trials were initiated more than two decades ago. In the early days, gene therapy shared the fate of many experimental medicine…”
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Distinct routes of lineage development reshape the human blood hierarchy across ontogeny by Notta, Faiyaz, Zandi, Sasan, Takayama, Naoya, Dobson, Stephanie, Gan, Olga I., Wilson, Gavin, Kaufmann, Kerstin B., McLeod, Jessica, Laurenti, Elisa, Dunant, Cyrille F., McPherson, John D., Stein, Lincoln D., Dror, Yigal, Dick, John E.

“…In a classical view of hematopoiesis, the various blood cell lineages arise via a hierarchical scheme starting with multipotent stem cells that become…”
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Constructing Professional Identity: The Role of Work and Identity Learning Cycles in the Customization of Identity among Medical Residents by Pratt, Michael G., Rockmann, Kevin W., Kaufmann, Jeffrey B.

“…Through a six-year qualitative study of medical residents, we build theory about professional identity construction. We found that identity construction was…”
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Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals by Grant, Sarah Schmidt, Kaufmann, Benjamin B, Chand, Nikhilesh S, Haseley, Nathan, Hung, Deborah T

“…During Mycobacterium tuberculosis infection, a population of bacteria likely becomes refractory to antibiotic killing in the absence of genotypic resistance,…”
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Contributions of low molecule number and chromosomal positioning to stochastic gene expression by van Oudenaarden, Alexander, Becskei, Attila, Kaufmann, Benjamin B

“…The presence of low-copy-number regulators and switch-like signal propagation in regulatory networks are expected to increase noise in cellular processes. We…”
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Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal by Xie, Stephanie Z., Garcia-Prat, Laura, Voisin, Veronique, Ferrari, Robin, Gan, Olga I., Wagenblast, Elvin, Kaufmann, Kerstin B., Zeng, Andy G.X., Takayanagi, Shin-ichiro, Patel, Ishita, Lee, Esther K., Jargstorf, Joseph, Holmes, Gareth, Romm, Guy, Pan, Kristele, Shoong, Michelle, Vedi, Aditi, Luberto, Chiara, Minden, Mark D., Bader, Gary D., Laurenti, Elisa, Dick, John E.

“…Cellular stress responses serve as crucial decision points balancing persistence or culling of hematopoietic stem cells (HSCs) for lifelong blood production…”
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Perioperative cytokine profile during lung surgery predicts patients at risk for postoperative complications-A prospective, clinical study by Kaufmann, Kai B, Heinrich, Sebastian, Staehle, Hans Felix, Bogatyreva, Lioudmila, Buerkle, Hartmut, Goebel, Ulrich

“…Postoperative complications after lung surgery are frequent, having a detrimental effect on patients' further course. Complications may lead to an increased…”
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The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells Is Governed by Dynamic 3D Genome Reorganization by Takayama, Naoya, Murison, Alex, Takayanagi, Shin-ichiro, Arlidge, Christopher, Zhou, Stanley, Garcia-Prat, Laura, Chan-Seng-Yue, Michelle, Zandi, Sasan, Gan, Olga I., Boutzen, Héléna, Kaufmann, Kerstin B., Trotman-Grant, Aaron, Schoof, Erwin, Kron, Ken, Díaz, Noelia, Lee, John J.Y., Medina, Tiago, De Carvalho, Daniel D., Taylor, Michael D., Vaquerizas, Juan M., Xie, Stephanie Z., Dick, John E., Lupien, Mathieu

“…Lifelong blood production requires long-term hematopoietic stem cells (LT-HSCs), marked by stemness states involving quiescence and self-renewal, to transition…”
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Optimizing the trade-off between spatial and genetic sampling efforts in patchy populations: towards a better assessment of functional connectivity using an individual-based sampling scheme by Prunier, J. G., Kaufmann, B., Fenet, S., Picard, D., Pompanon, F., Joly, P., Lena, J. P.

“…Genetic data are increasingly used in landscape ecology for the indirect assessment of functional connectivity, that is, the permeability of landscape to…”
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Double-barrel STA-MCA bypass for cerebral revascularization: lessons learned from a 10-year experience by Kan, Peter, Srinivasan, Visish M, Srivatsan, Aditya, Kaufmann, Ascher B, Cherian, Jacob, Burkhardt, Jan-Karl, Johnson, Jeremiah, Duckworth, Edward A M

“…In select patients, extracranial-intracranial (EC-IC) bypass remains an important tool for cerebral revascularization. Traditionally, superficial temporal…”
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miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells by Lechman, Eric R., Gentner, Bernhard, Ng, Stanley W.K., Schoof, Erwin M., van Galen, Peter, Kennedy, James A., Nucera, Silvia, Ciceri, Fabio, Kaufmann, Kerstin B., Takayama, Naoya, Dobson, Stephanie M., Trotman-Grant, Aaron, Krivdova, Gabriela, Elzinga, Janneke, Mitchell, Amanda, Nilsson, Björn, Hermans, Karin G., Eppert, Kolja, Marke, Rene, Isserlin, Ruth, Voisin, Veronique, Bader, Gary D., Zandstra, Peter W., Golub, Todd R., Ebert, Benjamin L., Lu, Jun, Minden, Mark, Wang, Jean C.Y., Naldini, Luigi, Dick, John E.

“…To investigate miRNA function in human acute myeloid leukemia (AML) stem cells (LSC), we generated a prognostic LSC-associated miRNA signature derived from…”
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Response to the Letter by Schenke et al. on “Auditory spatial cueing reduces neglect after righthemispheric stroke: A proof of concept study” by Kaufmann et al., 2022 by Kaufmann, B.C., Cazzoli, D., Bartolomeo, P., Geiser, N., Nef, T., Nyffeler, T.

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The CORM ALF-186 Mediates Anti-Apoptotic Signaling via an Activation of the p38 MAPK after Ischemia and Reperfusion Injury in Retinal Ganglion Cells by Ulbrich, Felix, Kaufmann, Kai B, Meske, Alexander, Lagrèze, Wolf A, Augustynik, Michael, Buerkle, Hartmut, Ramao, Carlos C, Biermann, Julia, Goebel, Ulrich

“…Ischemia and reperfusion injury may induce apoptosis and lead to sustained tissue damage and loss of function, especially in neuronal organs. While carbon…”
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Urbanization without isolation: the absence of genetic structure among cities and forests in the tiny acorn ant Temnothorax nylanderi by Khimoun, A, Doums, C, Molet, M, Kaufmann, B, Peronnet, R, Eyer, P A, Mona, S

“…Urban alteration of neutral and adaptive evolutionary processes is still underexplored. Using a genome-wide SNP dataset, we investigated (i) urban-induced…”
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Addressing the sustainable urbanism paradox: tipping points for the operational reconciliation of dense and green morphologies by Boutreux, T., Bourgeois, M., Bellec, A., Commeaux, F., Kaufmann, B.

“…To improve biodiversity and human living conditions in the Anthropocene, urban forms must reconcile density with vegetation to meet the dual…”
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Surface Functionalization of Orthopedic Titanium Implants with Bone Sialoprotein by Baranowski, Andreas, Klein, Anja, Ritz, Ulrike, Ackermann, Angelika, Anthonissen, Joris, Kaufmann, Kerstin B, Brendel, Christian, Götz, Hermann, Rommens, Pol M, Hofmann, Alexander

“…Orthopedic implant failure due to aseptic loosening and mechanical instability remains a major problem in total joint replacement. Improving osseointegration…”
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Auditory spatial cueing reduces neglect after right-hemispheric stroke: A proof of concept study by Kaufmann, B.C., Cazzoli, D., Bartolomeo, P., Frey, J., Pflugshaupt, T., Knobel, S.E.J., Nef, T., Müri, R.M., Nyffeler, T.

“…Spatial neglect after right-hemispheric stroke, characterized by the failure to attend or respond to the contralesional space, is a strong negative outcome…”
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Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation by Xie, Stephanie Z, Kaufmann, Kerstin B, Wang, Weijia, Chan-Seng-Yue, Michelle, Gan, Olga I, Laurenti, Elisa, Garcia-Prat, Laura, Takayanagi, Shin-Ichiro, Ng, Stanley W K, Xu, ChangJiang, Zeng, Andy G X, Jin, Liqing, McLeod, Jessica, Wagenblast, Elvin, Mitchell, Amanda, Kennedy, James A, Liu, Qiang, Boutzen, Héléna, Kleinau, Melissa, Jargstorf, Joseph, Holmes, Gareth, Zhang, Yang, Voisin, Veronique, Bader, Gary D, Wang, Jean C Y, Hannun, Yusuf A, Luberto, Chiara, Schroeder, Timm, Minden, Mark D, Dick, John E

“…Acute myeloid leukemia (AML) is a caricature of normal hematopoiesis, driven from leukemia stem cells (LSC) that share some hematopoietic stem cell (HSC)…”
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ABT-888 restores sensitivity in temozolomide resistant glioma cells and xenografts by Yuan, Alice L, Ricks, Christian B, Bohm, Alexandra K, Lun, Xueqing, Maxwell, Lori, Safdar, Shahana, Bukhari, Shazreh, Gerber, Amanda, Sayeed, Wajid, Bering, Elizabeth A, Pedersen, Haley, Chan, Jennifer A, Shen, Yaoqing, Marra, Marco, Kaplan, David R, Mason, Warren, Goodman, Lindsey D, Ezhilarasan, Ravesanker, Kaufmann, Ascher B, Cabral, Matthew, Robbins, Steve M, Senger, Donna L, Cahill, Daniel P, Sulman, Erik P, Cairncross, J Gregory, Blough, Michael D

“…Temozolomide (TMZ) is active against glioblastomas (GBM) in which the O6-methylguanine-DNA methyltransferase (MGMT) gene is silenced. However, even in…”
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