Search Results - "Kaufman, J J"

The impact of the endoplasmic reticulum protein-folding environment on cancer development by Wang, Miao, Kaufman, Randal J.

“…Key Points Defective protein folding in the endoplasmic reticulum (ER) and unfolded protein response (UPR) activation are documented in many human cancer…”
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The role of ER stress in lipid metabolism and lipotoxicity by Han, Jaeseok, Kaufman, Randal J.

“…The endoplasmic reticulum (ER) is a cellular organelle important for regulating calcium homeostasis, lipid metabolism, protein synthesis, and posttranslational…”
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Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease by Cao, Stewart Siyan, Kaufman, Randal J

“…The endoplasmic reticulum (ER) is a specialized organelle for the folding and trafficking of proteins, which is highly sensitive to changes in intracellular…”
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Mechanisms, regulation and functions of the unfolded protein response by Hetz, Claudio, Zhang, Kezhong, Kaufman, Randal J.

“…Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at the endoplasmic reticulum (ER) is emerging as a possible driver of…”
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The impact of the unfolded protein response on human disease by Wang, Shiyu, Kaufman, Randal J

“…A central function of the endoplasmic reticulum (ER) is to coordinate protein biosynthetic and secretory activities in the cell. Alterations in ER homeostasis…”
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Endoplasmic Reticulum Stress and Type 2 Diabetes by Back, Sung Hoon, Kaufman, Randal J

“…Given the functional importance of the endoplasmic reticulum (ER), an organelle that performs folding, modification, and trafficking of secretory and membrane…”
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Vitamin D supplementation in elderly or postmenopausal women: a 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) by Rizzoli, R., Boonen, S., Brandi, M.-L., Bruyère, O., Cooper, C., Kanis, J.A., Kaufman, J.-M., Ringe, J.D., Weryha, G., Reginster, J.-Y.

“…Abstract Background:Vitamin D insufficiency has deleterious consequences on health outcomes. In elderly or postmenopausal women, it may exacerbate…”
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Is there a role for menopausal hormone therapy in the management of postmenopausal osteoporosis? by Rozenberg, S., Al-Daghri, N., Aubertin-Leheudre, M., Brandi, M.-L., Cano, A., Collins, P., Cooper, C., Genazzani, A. R., Hillard, T., Kanis, J.A., Kaufman, J.-M., Lambrinoudaki, I., Laslop, A., McCloskey, E., Palacios, S., Prieto-Alhambra, D., Reginster, J.-Y., Rizzoli, R., Rosano, G., Trémollieres, F., Harvey, N.C.

“…We provide an evidence base and guidance for the use of menopausal hormone therapy (MHT) for the maintenance of skeletal health and prevention of future…”
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Physiological/pathological ramifications of transcription factors in the unfolded protein response by Han, Jaeseok, Kaufman, Randal J

“…Numerous environmental, physiological, and pathological insults disrupt protein-folding homeostasis in the endoplasmic reticulum (ER), referred to as ER…”
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Frailty and sarcopenia: definitions and outcome parameters by Cooper, C., Dere, W., Evans, W., Kanis, J. A., Rizzoli, R., Sayer, A. A., Sieber, C. C., Kaufman, J.-M., Abellan van Kan, G., Boonen, S., Adachi, J., Mitlak, B., Tsouderos, Y., Rolland, Y., Reginster, J.-Y. L.

“…An operational definition of musculoskeletal decline in older people is needed to allow development of interventions for prevention or treatment, as was…”
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The mammalian unfolded protein response by Schröder, Martin, Kaufman, Randal J

“…In the endoplasmic reticulum (ER), secretory and transmembrane proteins fold into their native conformation and undergo posttranslational modifications…”
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Bone Mass, Bone Geometry, and Body Composition in Female-to-Male Transsexual Persons after Long-Term Cross-Sex Hormonal Therapy by Van Caenegem, E, Wierckx, K, Taes, Y, Dedecker, D, Van de Peer, F, Toye, K, Kaufman, J.-M, T'Sjoen, G

“…Context: Female-to-male transsexual persons (transsexual men) undergo extreme hormonal changes due to ovariectomy and testosterone substitution, allowing…”
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Prevalence of cardiovascular disease and cancer during cross-sex hormone therapy in a large cohort of trans persons: a case–control study by Wierckx, K, Elaut, E, Declercq, E, Heylens, G, De Cuypere, G, Taes, Y, Kaufman, J M, T'Sjoen, G

“…ObjectiveThis study evaluated the short- and long-term cardiovascular- and cancer-related morbidities during cross-sex hormone therapy in a large sample of…”
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Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? by Malhotra, Jyoti D, Kaufman, Randal J

“…The endoplasmic reticulum (ER) is a well-orchestrated protein-folding machine composed of protein chaperones, proteins that catalyze protein folding, and…”
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ER stress and its functional link to mitochondria: role in cell survival and death by Malhotra, Jyoti D, Kaufman, Randal J

“…The endoplasmic reticulum (ER) is the primary site for synthesis and folding of secreted and membrane-bound proteins. Proteins are translocated into ER lumen…”
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Orchestrating the unfolded protein response in health and disease by Kaufman, Randal J

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From acute ER stress to physiological roles of the Unfolded Protein Response by Wu, J, Kaufman, R J

“…When protein folding in the endoplasmic reticulum (ER) is disrupted by alterations in homeostasis in the ER lumen, eucaryotic cells activate a series of signal…”
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Strain stiffening in collagen I networks by Motte, Stéphanie, Kaufman, Laura J.

“…Biopolymer gels exhibit strain stiffening that is generally not seen in synthetic gels. Here, we investigate the strain‐stiffening behavior in collagen I gels…”
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Osteoporosis in young adults: pathophysiology, diagnosis, and management by Ferrari, S., Bianchi, M. L., Eisman, J. A., Foldes, A. J., Adami, S., Wahl, D. A., Stepan, J. J., de Vernejoul, M.-C., Kaufman, J.-M.

“…Postmenopausal osteoporosis is mainly caused by increased bone remodeling resulting from estrogen deficiency. Indications for treatment are based on low areal…”
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Assessment of Cardiovascular Safety of Anti-Osteoporosis Drugs by Fuggle, N. R., Cooper, C., Harvey, N. C., Al-Daghri, N., Brandi, M.-L., Bruyere, O., Cano, A., Dennison, E. M., Diez-Perez, A., Kaufman, J.-M., Palacios, S., Prieto-Alhambra, D., Rozenberg, S., Thomas, T., Tremollieres, F., Rizzoli, R., Kanis, J. A., Reginster, J. Y.

“…The incidence of osteoporosis and cardiovascular disease increases with age, and there are potentially shared mechanistic associations between the two…”
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