Search Results - "Kaufman, David G"

Abasic sites preferentially form at regions undergoing DNA replication by Chastain, Paul D. II, Nakamura, Jun, Rao, Shangbang, Chu, Haitao, Ibrahim, Joseph G, Swenberg, James A, Kaufman, David G

“…We investigated whether apurinic/apyrimidinic (AP/abasic) sites were more frequent in regions of DNA replication in cells and whether their number increased…”
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Beyond the Syndrome: Extensive Congenital Abnormalities in an Infant With Trisomy 21 by Ward, Jeremy D, Sharma, Mahesh S, Pizzuto, Matthew F, Moylan, Vincent J, Askin, Frederic B, Kaufman, David G

“…Herein we discuss the clinical course and subsequent autopsy of a female infant with trisomy 21 with balanced Rastelli Type “C” complete atrioventricular…”
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The need for rapid therapeutic efficacy testing for cancer therapy by Kaufman, David G.

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Temporal differences in DNA replication during the S phase using single fiber analysis of normal human fibroblasts and glioblastoma T98G cells by Frum, Rebecca A., Khondker, Zakaria S., Kaufman, David G.

“…We have recently shown that replication forks pause near origins in normal human fibroblasts (NHF1-hTERT) but not glioblastoma T98G cells.  This observation…”
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FEN1 functions in long patch base excision repair under conditions of oxidative stress in vertebrate cells by Asagoshi, Kenjiro, Tano, Keizo, Chastain, 2nd, Paul D, Adachi, Noritaka, Sonoda, Eiichiro, Kikuchi, Koji, Koyama, Hideki, Nagata, Kenji, Kaufman, David G, Takeda, Shunichi, Wilson, Samuel H, Watanabe, Masami, Swenberg, James A, Nakamura, Jun

“…From in vitro studies, flap endonuclease 1 (FEN1) has been proposed to play a role in the long patch (LP) base excision repair (BER) subpathway. Yet the role…”
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Checkpoint Regulation of Replication Dynamics in UV-Irradiated Human Cells by Chastain II, Paul D., Heffernan, Timothy P., Nevis, Kathleen, Lin, Li, Kaufmann, William K., Kaufman, David G., Cordeiro-Stone, Marila

“…At any moment during S phase, regions of genomic DNA are in various stages of replication (i.e. initiation, chain elongation, and termination). These stages…”
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Decidual Differentiation of Stromal Cells Promotes Proprotein Convertase 5/6 Expression and Lefty Processing by Tang, Meiyi, Mikhailik, Anatoly, Pauli, Ilse, Giudice, Linda C, Fazelabas, Asgerally T, Tulac, Suzana, Carson, Daniel D, Kaufman, David G, Barbier, Claire, Creemers, John W. M, Tabibzadeh, Siamak

“…Lefty/Ebaf polypeptides, novel members of the TGF-β superfamily, are involved in endometrial differentiation and embryo implantation. Recently, we showed that,…”
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DNA replication in early S phase pauses near newly activated origins by Frum, Rebecca A., Chastain II, Paul D., Qu, Pingping, Cohen, Stephanie M., Kaufman, David G.

“…During the S phase of the cell cycle, the entire genome is replicated. There is a high level of orderliness to this process through the temporally and…”
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Expression of Exogenous Human Telomerase in Cultures of Endometrial Stromal Cells Does Not Alter Their Hormone Responsiveness by BARBIER, Claire S, BECKER, Karen A, TROESTER, Melissa A, KAUFMAN, David G

“…In the human endometrium, stromal cells mediate the proliferative response of epithelial cells to the steroid hormones estrogen and progesterone. These…”
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Genome-wide sequence and functional analysis of early replicating DNA in normal human fibroblasts by Cohen, Stephanie M, Furey, Terrence S, Doggett, Norman A, Kaufman, David G

“…The replication of mammalian genomic DNA during the S phase is a highly coordinated process that occurs in a programmed manner. Recent studies have begun to…”
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DNA replication and the GINS complex: localization on extended chromatin fibers by Cohen, Stephanie M, Chastain, 2nd, Paul D, Cordeiro-Stone, Marila, Kaufman, David G

“…The GINS complex is thought to be essential for the processes of initiation and elongation of DNA replication. This complex contains four subunits, one of…”
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A Late Origin of DNA Replication in the Trinucleotide Repeat Region of the Human FMR2 Gene by Chastain, 2nd, Paul D, Cohen, Stephanie M, Brylawski, Bruna P, Cordeiro-Stone, Marila, Kaufman, David G

“…We confirmed that the replication of the fragile-X E site (FRAXE) in human chromosomal band Xq28 occurs at six hours into the eight-hour S phase of normal…”
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SWI/SNF complexes are required for full activation of the DNA-damage response by Smith-Roe, Stephanie L, Nakamura, Jun, Holley, Darcy, Chastain, 2nd, Paul D, Rosson, Gary B, Simpson, Dennis A, Ridpath, John R, Kaufman, David G, Kaufmann, William K, Bultman, Scott J

“…SWI/SNF complexes utilize BRG1 (also known as SMARCA4) or BRM (also known as SMARCA2) as alternative catalytic subunits with ATPase activity to remodel…”
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BRG1 co-localizes with DNA replication factors and is required for efficient replication fork progression by Cohen, Stephanie M, Chastain, Paul D. II, Rosson, Gary B, Groh, Beezly S, Weissman, Bernard E, Kaufman, David G, Bultman, Scott J

“…For DNA replication to occur, chromatin must be remodeled. Yet, we know very little about which proteins alter nucleosome occupancy at origins and replication…”
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Endometrial stromal cells regulate epithelial cell growth in vitro: a new co-culture model by Arnold, Julia T., Kaufman, David G., Seppälä, Markku, Lessey, Bruce A.

“…The regulation of epithelial cell function and morphogenesis by the paracrine effectors from the mesenchyme or stroma has been well established using in-vivo…”
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Re-establishment of gap junctional intercellular communication (GJIC) between human endometrial carcinomas by prostaglandin E2 by Schlemmer, Scott R., Kaufman, David G.

“…Reduced intercellular communication via gap junctions is correlated with carcinogenesis. Gap junctional intercellular communication (GJIC), between normal…”
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Genistein effects on stromal cells determines epithelial proliferation in endometrial co-cultures by Sampey, Brante P., Lewis, Terrence D., Barbier, Claire S., Makowski, Liza, Kaufman, David G.

“…Estrogen is the leading etiologic factor for endometrial cancer. Estrogen-induced proliferation of endometrial epithelial cells normally requires paracrine…”
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Early replication and the apoptotic pathway by Cohen, Stephanie M., Cordeiro-Stone, Marila, Kaufman, David G.

“…In higher eukaryotes there is a link between time of replication and transcription. It is generally accepted that genes that are actively transcribed are…”
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Effect of normal endometrial stroma on growth and differentiation in Ishikawa endometrial adenocarcinoma cells by ARNOLD, Julia T, LESSEY, Bruce A, SEPPÄLÄ, Markku, KAUFMAN, David G

“…Endometrial cancer is characterized by alterations in the stromal cells and the supporting extracellular matrix in addition to the intrinsic alterations of the…”
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Effects of tibolone metabolites on human endometrial cell lines in co-culture by Barbier, Claire, Kloosterboer, Helenius J, Kaufman, David G

“…In human endometrium, cell proliferation is regulated by ovarian steroids through heterotypic interactions between stromal and epithelial cells populating this…”
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