Search Results - "Kauffman, R E"

A randomized comparison of ketorolac tromethamine and morphine for postoperative analgesia in critically ill children by Lieh-Lai, Mary W, Kauffman, Ralph E, Uy, Herbert G, Danjin, Millie, Simpson, Pippa M

“…OBJECTIVES:To evaluate the efficacy of a single dose of ketorolac compared with morphine for the relief of pain in children, and to determine the safety of…”
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Identity-by-descent and association mapping of a recessive gene for Hirschsprung disease on human chromosome 13q22 by Puffenberger, E G, Kauffman, E R, Bolk, S, Matise, T C, Washington, S S, Angrist, M, Weissenbach, J, Garver, K L, Mascari, M, Ladda, R

“…Hirschsprung disease (HSCR) is a congenital disorder of unknown etiology characterized by the absence of enteric ganglia in the distal colon. We have…”
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Essential drugs for infants and children : North American perspective by KAUFFMAN, R. E

“…A coordinated effort must be made to review many commonly used drugs and formulate an appropriate dosage for children. About 80% of the prescription drugs in…”
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Enantiomer-selective pharmacokinetics and metabolism of ketorolac in children by Kauffman, Ralph E., Lieh‐Lai, Mary W., Uy, Herbert G., Aravind, M. K.

“…Objective To compare the pharmacokinetics and metabolism of R (+)‐ and S (−)‐ ketorolac in children. Methods Children from 3 to 18 years old received 0.6 mg/kg…”
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Is the "therapeutic orphan" about to be adopted? by Coté, C J, Kauffman, R E, Troendle, G J, Lambert, G H

“…In this issue of Pediatrics, the Committee on Drugs (COD) has examined the continued problem of the "unapproved" use of "approved" medications in pediatrics.1…”
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Flumazenil in children after esophagogastroduodenoscopy by Peters, John M, Tolia, Vasu, Simpson, Pippa, Aravind, Manaphanath K, Kauffman, Ralph E

“…Our aim was to evaluate if the routine use of the benzodiazepine antagonist flumazenil would shorten postprocedure recovery times after…”
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Pharmacokinetic studies in paediatric patients: clinical and ethical considerations by KAUFFMAN, R. E, KEARNS, G. L

“…Important advances in paediatric clinical pharmacology have been made over the past 2 decades. However, there remains a reluctance to pursue pharmacodynamic…”
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Adverse drug reactions in children leading to hospital admission by MITCHELL, A. A, LACOUTURE, P. G, SHEEHAN, J. E, KAUFFMAN, R. E, SHAPIRO, S

“…To provide information regarding pediatric hospital admissions prompted by adverse drug reactions, data were reviewed from an intensive drug surveillance…”
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Effect of age on ibuprofen pharmacokinetics and antipyretic response by Kauffman, R E, Nelson, M V

“…The effect of age on ibuprofen pharmacokinetics and antipyretic effect was studied in 49 infants and children aged 3 months to 10.4 years. The relationship of…”
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Clinical trials in children: problems and pitfalls by Kauffman, R E

“…Recent initiatives by the US Congress and the Food and Drug Administration have provided effective incentives to develop new drugs for children leading to a…”
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Comparison of simultaneous esophageal pH monitoring and scintigraphy in infants with gastroesophageal reflux by Tolia, V, Kuhns, L, Kauffman, R E

“…Twenty-nine infants under 1 yr of age were studied by simultaneous esophageal pH monitoring and scintigraphy for evaluation of gastroesophageal reflux (GER)…”
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Rifapentine pharmacokinetics in adolescents by MARSHALL, JAMES D, ABDEL-RAHMAN, SUSAN, JOHNSON, KATHY, KAUFFMAN, RALPH E, KEARNS, GREGORY L

“…OBJECTIVE.Determination of rifapentine pharmacokinetics in healthy adolescent children. DESIGN.Prospective Phase II clinical trial. SETTING.Clinical research…”
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Drug trials in children: ethical, legal, and practical issues by Kauffman, R E

“…Technical limitations, logistic challenges, and ethical constraints no longer provide excuses for not conducting well-designed studies of therapeutic agents in…”
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Pharmacokinetic and pharmacodynamic study of midazolam in children during esophagogastroduodenoscopy by Tolia, V, Brennan, S, Aravind, M K, Kauffman, R E

“…We undertook a prospective study to evaluate the relationship between the onset and degree of sedation and the midazolam plasma concentration in children…”
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Developmental pharmacology: Drug disposition, action, and therapy in infants and children by KEARNS, Gregory L, ABDEL-RAHMAN, Susan M, ALANDER, Sarah W, BLOWEY, Douglas L, LEEDER, J. Steven, KAUFFMAN, Ralph E

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Status of drug approval processes and regulation of medications for children by Kauffman, R E

“…The term therapeutic orphan was coined in 1968 to describe the exclusion of infants and children from approved indications for use of the majority of drugs…”
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Guidelines for the Ethical Conduct of Studies to Evaluate Drugs in Pediatric Populations by Kauffman, Ralph E, Banner, William Jr, Berlin, Cheston M, Blumer, Jeffrey L

“…These guidelines are designed to provide a format allowing for the protection of child subjects in drug research. Research involving children carries with it…”
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The transfer of drugs and other chemicals into human milk by Kauffman, Ralph E, Banner, William Jr, Berlin, Cheston M, Blumer, Jeffrey L

“…This statement revises the 1983 and 1989 positions of the American Academy of Pediatrics, Committee on Drugs. It provides tables listing agents transferred…”
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Capillary Blood Collection by Paper for Lead Analysis by Graphite Furnace Atomic Absorption Spectrometry by Yee, H.Y., Srivuthana, K., Elton, R., Bhambhani, K., Kauffman, R.E.

“…A lead testing method is described that utilizes fingerstick capillary blood collected on Schleicher & Schuell 903 paper. The dried blood is eluted by…”
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Pharmacokinetics of erythropoietin following single-dose subcutaneous administration in preterm infants by Krishnan, R, Shankaran, S, Krishnan, M, Kauffman, R E, Kumar, P, Lucena, J

“…The pharmacokinetics of recombinant human erythropoietin was studied in 12 very low birth weight preterm infants < 32 weeks of gestation after subcutaneous…”
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