Search Results - "Kauffman, John F."

Rapid Limit Tests for Metal Impurities in Pharmaceutical Materials by X-ray Fluorescence Spectroscopy Using Wavelet Transform Filtering by Arzhantsev, Sergey, Li, Xiang, Kauffman, John F

“…We introduce a new method for analysis of X-ray fluorescence (XRF) spectra based on continuous wavelet transform filters, and the method is applied to the…”
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Standardization of Raman spectra for transfer of spectral libraries across different instruments by Rodriguez, Jason D, Westenberger, Benjamin J, Buhse, Lucinda F, Kauffman, John F

“…In this paper we evaluate methods for standardization of Raman spectra that are required to improve spectral correlation computations between spectra measured…”
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Raman detected differential scanning calorimetry of polymorphic transformations in acetaminophen by Kauffman, John F., Batykefer, Linda M., Tuschel, David D.

“…Acetaminophen is known to crystallize in three polymorphic forms. Thermally induced transformations between the crystalline forms and the super-cooled liquid…”
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Raman imaging of pharmaceutical materials: Refractive index effects on contrast at buried interfaces by Mecker-Pogue, Laura C., Kauffman, John F.

“…•Raman resolution targets were fabricated to mimic pharmaceutical materials.•Reflection at the PEG/PDMS interface contributes to the Raman signal.•Model based…”
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Raman spectroscopy of coated pharmaceutical tablets and physical models for multivariate calibration to tablet coating thickness by Kauffman, John F., Dellibovi, Marybeth, Cunningham, Charles R.

“…Raman spectra of a set of coated pharmaceutical tablets were analyzed for the purpose of calibrating the spectra to tablet coating thickness. Acetaminophen…”
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Two-Photon Excitation of Substituted Enediynes by Kauffman, John F, Turner, Joseph M, Alabugin, Igor V, Breiner, Boris, Kovalenko, Serguei V, Badaeva, Ekaterina A, Masunov, Artëm, Tretiak, Sergei

“…Electronic spectroscopy of nine benzannelated enediynes and a related fulvene was studied under one-photon and two-photon excitation conditions. We utilize…”
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Elemental Impurities in Pharmaceutical Excipients by Li, Gang, Schoneker, Dave, Ulman, Katherine L, Sturm, Jason J, Thackery, Lisa M, Kauffman, John F

“…Control of elemental impurities in pharmaceutical materials is currently undergoing a transition from control based on concentrations in components of drug…”
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Deep-Ultraviolet Resonance Raman (DUVRR) Spectroscopy of Therapeutic Monoclonal Antibodies Subjected to Thermal Stress by Bueno, Justin, Long, Dianna, Kauffman, John F, Arzhantsev, Sergey

“…The structural assessment of Rituximab, an IgG1 mAb, was investigated with deep-ultraviolet resonance Raman (DUVRR) spectroscopy. DUVRR spectroscopy was used…”
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Selective melamine detection in multiple sample matrices with a portable Raman instrument using surface enhanced Raman spectroscopy-active gold nanoparticles by Mecker, Laura C., Tyner, Katherine M., Kauffman, John F., Arzhantsev, Sergey, Mans, Daniel J., Gryniewicz-Ruzicka, Connie M.

“…[Display omitted] ► Initial work for field deployable screening of melamine in multiple matrices. ► Without extensive sample preparation, colorimetric…”
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Near infrared spectroscopy of magnesium stearate hydrates and multivariate calibration of pseudopolymorph composition by Kauffman, John F, Tumuluri, Venkat, Guo, Changning, Spencer, John A, Doub, William H, Nichols, Gary A, Randle, Scot R, Wu, Stephen

“…Samples of magnesium stearate monohydrate and dihydrate were used to prepare standard mixtures of known pseudopolymorphic composition. Near infrared spectra…”
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Rapid screening of anti-infective drug products for counterfeits using Raman spectral library-based correlation methods by Loethen, Yvette L, Kauffman, John F, Buhse, Lucinda F, Rodriguez, Jason D

“…A new spectral library-based approach that is capable of screening a diverse set of finished drug products using only an active pharmaceutical ingredient…”
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Charge Transfer Kinetics and Solvatochromism of 1-(9-Anthryl)-3-(4-dimethylaniline) Propane in 1,4-Dioxane:  Nonideal Quadrupolar Charge Distribution and the Origin of the Dioxane Anomaly by Khajehpour, Mazdak, Kauffman, John F

“…The solvent 1,4-dioxane behaves like a polar solvent even though its dielectric constant is small. This excess polarity is referred to as the “dioxane…”
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Quantitative Evaluation of the Sensitivity of Library-Based Raman Spectral Correlation Methods by Rodriguez, Jason D, Westenberger, Benjamin J, Buhse, Lucinda F, Kauffman, John F

“…Library-based Raman spectral correlation methods are widely used in surveillance applications in multiple areas including the pharmaceutical industry, where…”
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Using a portable ion mobility spectrometer to screen dietary supplements for sibutramine by Dunn, Jamie D., Gryniewicz-Ruzicka, Connie M., Kauffman, John F., Westenberger, Benjamin J., Buhse, Lucinda F.

“…In response to recent incidents of undeclared sibutramine, an appetite suppressant found in dietary supplements, we developed a method to detect sibutramine…”
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Detection of undeclared erectile dysfunction drugs and analogues in dietary supplements by ion mobility spectrometry by Gryniewicz, Connie M., Reepmeyer, John C., Kauffman, John F., Buhse, Lucinda F.

“…An ion mobility spectrometry (IMS) method was developed to screen for the presence of undeclared synthetic erectile dysfunction (ED) drugs or drug analogues in…”
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Libraries, classifiers, and quantifiers: A comparison of chemometric methods for the analysis of Raman spectra of contaminated pharmaceutical materials by Gryniewicz-Ruzicka, Connie M., Rodriguez, Jason D., Arzhantsev, Sergey, Buhse, Lucinda F., Kauffman, John F.

“…► Raman method used to screen sorbitol for the presence of low level adulterants. ► Compared a Raman based library spectral correlation method to chemometric…”
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Assessment of the influence factors on in vitro testing of nasal sprays using Box-Behnken experimental design by Guo, Changning, Stine, Keith J., Kauffman, John F., Doub, William H.

“…The purpose of the research was to investigate the influences of actuation parameters and formulation physical properties on nasal spray delivery performance…”
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Excited State Isomerization Kinetics of 4-(Methanol)Stilbene:  Application of the Isodielectric Kramers−Hubbard Analysis by Wiemers, Kathy L, Kauffman, John F

“…Trans-4-(methanol)stilbene (HMS) is a member of the diphenylpolyene family with a methanol group appended to one of the phenyl rings of stilbene. In previous…”
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Quadrupolar Solvent Effects on Solvation and Reactivity of Solutes Dissolved in Supercritical CO2 by Kauffman, John F

“…This article presents an overview of our recent studies of solvation and unimolecular reactivity in liquids and supercritical fluids. We review our research on…”
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Synthesis and detection of N-sulfonated oversulfated chondroitin sulfate in marketplace heparin by Mans, Daniel J., Ye, Hongping, Dunn, Jamie D., Kolinski, Richard E., Long, Dianna S., Phatak, Nisarga L., Ghasriani, Houman, Buhse, Lucinda F., Kauffman, John F., Keire, David A.

“…N-sulfonated oversulfated chondroitin sulfate (NS–OSCS), recently reported as a potential threat to the heparin supply, was prepared along with its…”
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