Fetal bone grafts do not elicit allograft rejection because of protecting anti-Ia alloantibodies. Implications to the immune survival of fetuses in allogeneic mothers

In a previous study we showed that allografts of BN fetal bone, unlike allografts of adult bone, are not rejected by allogeneic recipients of the Lewis strain in spite of the existence of major histocompatibility complex (MHC) incompatibility between donors and hosts. In the present study, we analyz...

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Bibliographic Details
Published in:	Transplantation Vol. 28; no. 2; p. 88
Main Authors:	Segal, S, Siegal, T, Altaraz, H, Lev-El, A, Nevo, Z, Nebel, L, Katzenelson, A, Feldman, M
Format:	Journal Article
Language:	English
Published:	United States 01-08-1979
Subjects:	Animals Antibody Formation Bone and Bones - embryology Bone and Bones - immunology Bone Transplantation Female Fetus - immunology Graft Survival Histocompatibility Isoantibodies - immunology Isoantigens - immunology Mice Pregnancy Rats Transplantation, Homologous
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Summary:	In a previous study we showed that allografts of BN fetal bone, unlike allografts of adult bone, are not rejected by allogeneic recipients of the Lewis strain in spite of the existence of major histocompatibility complex (MHC) incompatibility between donors and hosts. In the present study, we analyzed the relationships existing between the host and fetal tissue that determine graft survival. We found that (1) the fetal BN graft, unlike adult grafts, induces in Lewis recipients a vigorous humoral response consisting mainly in the production of IgG antibody that seems to be directed against antigens of Ia-like specificities. (2) The BN rats are genetically defective in their capacity to respond to determinants and thus are not capable of producing anti-Ia antibodies; in accordance, Lewis fetal bone grafts are rejected by the BN recipients. (3) Chondrocytes isolated from fetal mouse bones do express Ia antigenic determinants. We suggest that the survival of an allogeneic fetal graft in an immunologically intact recipient depends on an active and selective immune response directed against the Ia components associated with the MHC on the embryonic and fetal cells. On the basis of these notions, we propose that the capacity of Ia determinants expressed on cells of the embryo, to elicit anti-Ia and IgG alloantibodies in the pregnant mother, determines the capacity of the embryo to escape rejection by the histoincompatible mother.
ISSN:	0041-1337
DOI:	10.1097/00007890-197908000-00003