Search Results - "Katzenellenbogen, Benita S."

Endocrine treatment in breast cancer: cure, resistance and beyond by Tryfonidis, Konstantinos, Zardavas, Dimitrios, Katzenellenbogen, Benita S, Piccart, Martine

“…Highlights • Hormone- receptor positive breast cancer constitutes the most frequent subtype • Clinical and molecular research is intense in this subtype •…”
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Targeting the oncogenic transcription factor FOXM1 to improve outcomes in all subtypes of breast cancer by Katzenellenbogen, Benita S, Guillen, Valeria Sanabria, Katzenellenbogen, John A

“…FOXM1 (Forkhead box M1) is an oncogenic transcription factor that is greatly upregulated in breast cancer and many other cancers where it promotes…”
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Highly sensitive quantitative imaging for monitoring single cancer cell growth kinetics and drug response by Mir, Mustafa, Bergamaschi, Anna, Katzenellenbogen, Benita S, Popescu, Gabriel

“…The detection and treatment of cancer has advanced significantly in the past several decades, with important improvements in our understanding of the…”
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Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation by Fanning, Sean W, Mayne, Christopher G, Dharmarajan, Venkatasubramanian, Carlson, Kathryn E, Martin, Teresa A, Novick, Scott J, Toy, Weiyi, Green, Bradley, Panchamukhi, Srinivas, Katzenellenbogen, Benita S, Tajkhorshid, Emad, Griffin, Patrick R, Shen, Yang, Chandarlapaty, Sarat, Katzenellenbogen, John A, Greene, Geoffrey L

“…Somatic mutations in the estrogen receptor alpha (ERα) gene (ESR1), especially Y537S and D538G, have been linked to acquired resistance to endocrine therapies…”
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The forkhead transcription factor FOXM1 promotes endocrine resistance and invasiveness in estrogen receptor-positive breast cancer by expansion of stem-like cancer cells by Bergamaschi, Anna, Madak-Erdogan, Zeynep, Kim, Yu Jin, Choi, Yoon-La, Lu, Hailing, Katzenellenbogen, Benita S

“…The forkhead transcription factor FOXM1 coordinates expression of cell cycle-related genes and plays a pivotal role in tumorigenesis and cancer progression. We…”
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Genomic Collaboration of Estrogen Receptor α and Extracellular Signal-Regulated Kinase 2 in Regulating Gene and Proliferation Programs by Madak-Erdogan, Zeynep, Lupien, Mathieu, Stossi, Fabio, Brown, Myles, Katzenellenbogen, Benita S.

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Non-nuclear estrogen receptor alpha activation in endothelium reduces cardiac ischemia-reperfusion injury in mice by Menazza, Sara, Sun, Junhui, Appachi, Swathi, Chambliss, Ken L, Kim, Sung Hoon, Aponte, Angel, Khan, Sohaib, Katzenellenbogen, John A, Katzenellenbogen, Benita S, Shaul, Philip W, Murphy, Elizabeth

“…Abstract Steroid hormone receptors including estrogen receptors (ER) classically function as ligand-regulated transcription factors. However, estrogens also…”
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Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis by Zhao, Yuechao, Gong, Ping, Chen, Yiru, Nwachukwu, Jerome C, Srinivasan, Sathish, Ko, CheMyong, Bagchi, Milan K, Taylor, Robert N, Korach, Kenneth S, Nettles, Kendall W, Katzenellenbogen, John A, Katzenellenbogen, Benita S

“…Estrogenic and inflammatory components play key roles in a broad range of diseases including endometriosis, a common estrogen-dependent gynecological disorder…”
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Endothelial ERα promotes glucose tolerance by enhancing endothelial insulin transport to skeletal muscle by Sacharidou, Anastasia, Chambliss, Ken, Peng, Jun, Barrera, Jose, Tanigaki, Keiji, Luby-Phelps, Katherine, Özdemir, İpek, Khan, Sohaib, Sirsi, Shashank R., Kim, Sung Hoon, Katzenellenbogen, Benita S., Katzenellenbogen, John A., Kanchwala, Mohammed, Sathe, Adwait A., Lemoff, Andrew, Xing, Chao, Hoyt, Kenneth, Mineo, Chieko, Shaul, Philip W.

“…The estrogen receptor (ER) designated ERα has actions in many cell and tissue types that impact glucose homeostasis. It is unknown if these include mechanisms…”
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Coordinated activation of c-Src and FOXM1 drives tumor cell proliferation and breast cancer progression by Nandi, Ipshita, Smith, Harvey W, Sanguin-Gendreau, Virginie, Ji, Linjia, Pacis, Alain, Papavasiliou, Vasilios, Zuo, Dongmei, Nam, Stella, Attalla, Sherif S, Kim, Sung Hoon, Lusson, Sierra, Kuasne, Hellen, Fortier, Anne-Marie, Savage, Paul, Martinez Ramirez, Constanza, Park, Morag, Katzenellenbogen, John A, Katzenellenbogen, Benita S, Muller, William J

“…Activation of the tyrosine kinase c-Src promotes breast cancer progression and poor outcomes, yet the underlying mechanisms are incompletely understood. Here,…”
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Genome-Wide Analysis of Estrogen Receptor α DNA Binding and Tethering Mechanisms Identifies Runx1 as a Novel Tethering Factor in Receptor-Mediated Transcriptional Activation by Stender, Joshua D., Kim, Kyuri, Charn, Tze Howe, Komm, Barry, Chang, Ken C. N., Kraus, W. Lee, Benner, Christopher, Glass, Christopher K., Katzenellenbogen, Benita S.

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Full antagonism of the estrogen receptor without a prototypical ligand side chain by Srinivasan, Sathish, Nwachukwu, Jerome C, Bruno, Nelson E, Dharmarajan, Venkatasubramanian, Goswami, Devrishi, Kastrati, Irida, Novick, Scott, Nowak, Jason, Cavett, Valerie, Zhou, Hai-Bing, Boonmuen, Nittaya, Zhao, Yuechao, Min, Jian, Frasor, Jonna, Katzenellenbogen, Benita S, Griffin, Patrick R, Katzenellenbogen, John A, Nettles, Kendall W

“…A sulfonamide series lacking the prototypical side chain behave as full antagonists or inverse agonists of estrogen receptor (ERα) signaling in a graded…”
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Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators by Madak‐Erdogan, Zeynep, Charn, Tze‐Howe, Jiang, Yan, Liu, Edison T, Katzenellenbogen, John A, Katzenellenbogen, Benita S

“…The closely related transcription factors (TFs), estrogen receptors ERα and ERβ, regulate divergent gene expression programs and proliferative outcomes in…”
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Whole-genome cartography of estrogen receptor alpha binding sites by Lin, Chin-Yo, Vega, Vinsensius B, Thomsen, Jane S, Zhang, Tao, Kong, Say Li, Xie, Min, Chiu, Kuo Ping, Lipovich, Leonard, Barnett, Daniel H, Stossi, Fabio, Yeo, Ailing, George, Joshy, Kuznetsov, Vladimir A, Lee, Yew Kok, Charn, Tze Howe, Palanisamy, Nallasivam, Miller, Lance D, Cheung, Edwin, Katzenellenbogen, Benita S, Ruan, Yijun, Bourque, Guillaume, Wei, Chia-Lin, Liu, Edison T

“…Using a chromatin immunoprecipitation-paired end diTag cloning and sequencing strategy, we mapped estrogen receptor alpha (ERalpha) binding sites in MCF-7…”
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Integration of molecular profiling and chemical imaging to elucidate fibroblast-microenvironment impact on cancer cell phenotype and endocrine resistance in breast cancer by Holton, Sarah E, Bergamaschi, Anna, Katzenellenbogen, Benita S, Bhargava, Rohit

“…The tumor microenvironment is known to play a key role in altering the properties and behavior of nearby cancer cells. Its influence on resistance to endocrine…”
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Nuclear and Extranuclear Pathway Inputs in the Regulation of Global Gene Expression by Estrogen Receptors by Madak-Erdogan, Zeynep, Kieser, Karen J, Kim, Sung Hoon, Komm, Barry, Katzenellenbogen, John A, Katzenellenbogen, Benita S

“…Whereas estrogens exert their effects by binding to nuclear estrogen receptors (ERs) and directly altering target gene transcription, they can also initiate…”
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The Activation Function-1 of Estrogen Receptor Alpha Prevents Arterial Neointima Development Through a Direct Effect on Smooth Muscle Cells by Smirnova, Natalia F, Fontaine, Coralie, Buscato, Mélissa, Lupieri, Adrien, Vinel, Alexia, Valera, Marie-Cécile, Guillaume, Maeva, Malet, Nicole, Foidart, Jean-Michel, Raymond-Letron, Isabelle, Lenfant, Francoise, Gourdy, Pierre, Katzenellenbogen, Benita S, Katzenellenbogen, John A, Laffargue, Muriel, Arnal, Jean-Francois

“…RATIONALE:17β-Estradiol (E2) exerts numerous beneficial effects in vascular disease. It regulates gene transcription through nuclear estrogen receptor α (ERα)…”
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Estrogen Receptor Alpha Represses Transcription of Early Target Genes via p300 and CtBP1 by Stossi, Fabio, Madak-Erdogan, Zeynep, Katzenellenbogen, Benita S

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NB compounds are potent and efficacious FOXM1 inhibitors in high-grade serous ovarian cancer cells by Liu, Cassie, Vorderbruggen, Makenzie, Muñoz-Trujillo, Catalina, Kim, Sung Hoon, Katzenellenbogen, John A, Katzenellenbogen, Benita S, Karpf, Adam R

“…Genetic studies implicate the oncogenic transcription factor Forkhead Box M1 (FOXM1) as a potential therapeutic target in high-grade serous ovarian cancer…”
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Extranuclear estrogen receptor-α stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis by Wong, Winifred P.S, Tiano, Joseph P, Liu, Suhuan, Hewitt, Sylvia C, Le May, Cedric, Dalle, Stéphane, Katzenellenbogen, John A, Katzenellenbogen, Benita S, Korach, Kenneth S, Mauvais-Jarvis, Franck

“…Estrogen receptors (ERs) protect pancreatic islet survival in mice through rapid extranuclear actions. ERα also enhances insulin synthesis in cultured islets…”
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