Search Results - "Katzenelenbogen, Yonatan"

In Synergy: Optimizing CAR T Development and Personalizing Patient Care Using Single-Cell Technologies by Barboy, Oren, Katzenelenbogen, Yonatan, Shalita, Rotem, Amit, Ido

“…Chimeric antigen receptor (CAR) T therapies hold immense promise to revolutionize cancer treatment. Nevertheless, key challenges, primarily in solid tumor…”
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Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer by Katzenelenbogen, Yonatan, Sheban, Fadi, Yalin, Adam, Yofe, Ido, Svetlichnyy, Dmitry, Jaitin, Diego Adhemar, Bornstein, Chamutal, Moshe, Adi, Keren-Shaul, Hadas, Cohen, Merav, Wang, Shuang-Yin, Li, Baoguo, David, Eyal, Salame, Tomer-Meir, Weiner, Assaf, Amit, Ido

“…Cell function and activity are regulated through integration of signaling, epigenetic, transcriptional, and metabolic pathways. Here, we introduce INs-seq, an…”
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Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma by Kirschenbaum, Daniel, Xie, Ken, Ingelfinger, Florian, Katzenelenbogen, Yonatan, Abadie, Kathleen, Look, Thomas, Sheban, Fadi, Phan, Truong San, Li, Baoguo, Zwicky, Pascale, Yofe, Ido, David, Eyal, Mazuz, Kfir, Hou, Jinchao, Chen, Yun, Shaim, Hila, Shanley, Mayra, Becker, Soeren, Qian, Jiawen, Colonna, Marco, Ginhoux, Florent, Rezvani, Katayoun, Theis, Fabian J, Yosef, Nir, Weiss, Tobias, Weiner, Assaf, Amit, Ido

“…Deciphering the cell-state transitions underlying immune adaptation across time is fundamental for advancing biology. Empirical in vivo genomic technologies…”
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Determinants of Response to Anti CD-19 CAR-T Cells for Diffuse Large B-Cell Lymphoma in Pre-Treatment Peripheral Blood Mononuclear Cells Using Single-Cell RNA-Seq by Ram, Ron, Katzenelenbogen, Yonatan, Gurevich Shapiro, Anna, Winter, Eitan, Barboy, Oren, Zada, Mor, Halevi, Shahar, David, Eyal, Avivi Mazza, Irit, Amit, Ido

“…Background: Chimeric antigen receptor T (CAR-T) cell therapy has become the standard of care in patients with relapsed/refractory diffuse large cell lymphoma…”
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p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells by Majewska, Julia, Agrawal, Amit, Mayo, Avi, Roitman, Lior, Chatterjee, Rishita, Sekeresova Kralova, Jarmila, Landsberger, Tomer, Katzenelenbogen, Yonatan, Meir-Salame, Tomer, Hagai, Efrat, Sopher, Ilanit, Perez-Correa, Juan-Felipe, Wagner, Wolfgang, Maimon, Avi, Amit, Ido, Alon, Uri, Krizhanovsky, Valery

“…The accumulation of senescent cells promotes ageing and age-related diseases, but molecular mechanisms that senescent cells use to evade immune clearance and…”
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Targeted delivery of tumor necrosis factor in combination with CCNU induces a T cell-dependent regression of glioblastoma by Look, Thomas, Puca, Emanuele, Bühler, Marcel, Kirschenbaum, Daniel, De Luca, Roberto, Stucchi, Riccardo, Ravazza, Domenico, Di Nitto, Cesare, Roth, Patrick, Katzenelenbogen, Yonatan, Weiner, Assaf, Rindlisbacher, Lukas, Becher, Burkhard, Amit, Ido, Weller, Michael, Neri, Dario, Hemmerle, Teresa, Weiss, Tobias

“…Glioblastoma is the most aggressive primary brain tumor with an unmet need for more effective therapies. Here, we investigated combination therapies based on…”
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Bispecific antibodies increase the therapeutic window of CD40 agonists through selective dendritic cell targeting by Salomon, Ran, Rotem, Hagar, Katzenelenbogen, Yonatan, Weiner, Assaf, Cohen Saban, Noy, Feferman, Tali, Amit, Ido, Dahan, Rony

“…Therapeutic use of agonistic anti-CD40 antibodies is a potentially powerful approach for activation of the immune response to eradicate tumors. However, the…”
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Unraveling the Mechanism of Action of Bispecific T-Cell Engagers in B-Cell Acute Lymphoblastic Leukemia Using Advanced Single-Cell Multiomics by Gurevich Shapiro, Anna, Winter, Eitan, Moshe, Yakir, Katzenelenbogen, Yonatan, Jaitin, Diego, Zada, Mor, Barboy, Oren, Yofe, Ido, Chalan, Paulina, Truong Phan, San, Giladi, Amir, Shapiro, Michael, Robinson, Renana, Kugler, Eitan, Wolach, Ofir, Avivi Mazza, Irit, Amit, Ido

“…Background Bispecific T-cell engagers (BiTEs) stimulate T lymphocytes proximate to tumor cells, inducing T-cell stimulation and tumor killing. Blinatumomab, an…”
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Abstract 84: Single-cell transcriptional analysis of multiple myeloma bone marrow aspirates using particle-templated instant partition sequencing (PIPseq) by Katzenelenbogen, Yonatan, Zada, Mor, Meltzer, Robert, Fontanez, Kristina, Amit, Ido

“…Abstract Single-cell RNA-seq technologies have dramatically evolved in recent years. Despite these advances, the field faces some significant limitations in…”
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Abstract 7122: A novel USP1 inhibitor coupled with a novel proteomic response biomarker for precision oncology therapy by Alchanati, Iris, Morley, Andrew, Hay-Koren, Avital, Fierro, Fabrizio, Otonin, Galina, Herman, Shay, Shtrikman, Alon, Katzenelenbogen, Yonatan, Arad, Gali, Tivon, Barr, Pevzner, Kirill, Seger, Eran

“…Abstract Ubiquitin-specific protease 1 (USP1) is a well-characterized deubiquitinating enzyme (DUB) that plays a critical role in DNA damage repair (DDR). It…”
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Abstract 5130: Phospho-proteomic dynamics reveal DNA damage and repair signatures of drug sensitivity by Arad, Gali, Hay-Koren, Avital, Simchi, Nitzan, Kovalerchik, Dimitri, Daitchman, Dina, Manor, Amit, Givton, Ofer, Lezmi, Elyad, Alchanati, Iris, Katzenelenbogen, Yonatan, Herman, Shay, Shtrikman, Alon, Otonin, Galina, Seger, Eran, Pevzner, Kirill

“…Abstract There are numerous drug development efforts of DNA damage response (DDR) targets, such as PARP, ATR, ATM, CHK1, where the ability to accurately…”
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Modeling T cell temporal response to cancer immunotherapy rationalizes development of combinatorial treatment protocols by Barboy, Oren, Bercovich, Akhiad, Li, Hanjie, Eyal-Lubling, Yaniv, Yalin, Adam, Shapir Itai, Yuval, Abadie, Kathleen, Zada, Mor, David, Eyal, Shlomi-Loubaton, Shir, Katzenelenbogen, Yonatan, Jaitin, Diego Adhemar, Gur, Chamutal, Yofe, Ido, Feferman, Tali, Cohen, Merav, Dahan, Rony, Newell, Evan W, Lifshitz, Aviezer, Tanay, Amos, Amit, Ido

“…Successful immunotherapy relies on triggering complex responses involving T cell dynamics in tumors and the periphery. Characterizing these responses remains…”
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