Search Results - "Katz, Stephen I."

Gain-of-Function Pyrin Mutations Induce NLRP3 Protein -Independent Interleukin-1β Activation and Severe Autoinflammation in Mice by Chae, Jae Jin, Cho, Young-Hun, Lee, Geun-Shik, Cheng, Jun, Liu, P. Paul, Feigenbaum, Lionel, Katz, Stephen I., Kastner, Daniel L.

“…Missense mutations in the C-terminal B30.2 domain of pyrin cause familial Mediterranean fever (FMF), the most common Mendelian autoinflammatory disease…”
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Histone deacetylase 6 inhibition impairs effector CD8 T-cell functions during skin inflammation by Tsuji, Gaku, MD, PhD, Okiyama, Naoko, MD, PhD, Villarroel, Vadim A., MD, Katz, Stephen I., MD, PhD

“…Background Broad-spectrum histone deacetylase (HDAC) inhibitors are useful in the treatment of allergic and autoimmune diseases and malignancy. However, use of…”
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Interferon regulatory factor 8 integrates T-cell receptor and cytokine-signaling pathways and drives effector differentiation of CD8 T cells by Miyagawa, Fumi, Zhang, Hong, Terunuma, Atshushi, Ozato, Keiko, Tagaya, Yutaka, Katz, Stephen I

“…We recently demonstrated that differentiation of cytotoxic T cells requires cooperation between T-cell receptor (TCR)/costimulation and γc-cytokines. Here we…”
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Commentary: Setting priorities for research funding at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) by Katz, Stephen I., MD, PhD

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Contact Hypersensitivity by Gaspari, Anthony A, Katz, Stephen I, Martin, Stefan F

“…Contact hypersensitivity (CHS) is a simple in vivo assay of cell-mediated immune function in which exposure of epidermal and dermal cells to exogenous haptens…”
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Keratinocytes Function as Accessory Cells for Presentation of Endogenous Antigen Expressed in the Epidermis by Kim, Brian S., Miyagawa, Fumi, Cho, Young-Hun, Bennett, Clare L., Clausen, Björn E., Katz, Stephen I.

“…The precise contribution(s) of skin dendritic cells (DCs) to immune responses in the skin has not been well delineated. We developed an intradermal (i.d.)…”
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Collared mice: A model to assess the effects of scratching by Takeuchi, Satoshi, Yasukawa, Fumiko, Furue, Masutaka, Katz, Stephen I

“…Abstract Background There is no current method to precisely assess pruritus despite its importance as a major symptom in many skin diseases. Pruritus induces…”
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Programmed cell death 1 (PD-1) regulates the effector function of CD8 T cells via PD-L1 expressed on target keratinocytes by Okiyama, Naoko, Katz, Stephen I

“…Abstract Programmed cell death 1 (PD-1) is an inhibitory molecule expressed by activated T cells. Its ligands (PD-L1 and -L2; PD-Ls) are expressed not only by…”
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Generation of a Large Number of Connective Tissue Type Mast Cells by Culture of Murine Fetal Skin Cells by Yamada, Nobuo, Matsushima, Hironori, Tagaya, Yutaka, Shimada, Shinji, Katz, Stephen I.

“…We describe a novel culture system for generating large numbers of murine skin-associated mast cells and distinguish their characteristics from bone…”
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Unity in Action by Katz, Stephen I.

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Dermatitis herpetiformis flare associated with use of triiodomethane packing strips for alveolar osteitis by Katz, Kenneth A., MD, MSc, MSCE, Roseman, Julie E, Roseman, Robert L., MD, Katz, Stephen I., MD, PhD

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Reversal of CD8 T-Cell–Mediated Mucocutaneous Graft-Versus-Host-Like Disease by the JAK Inhibitor Tofacitinib by Okiyama, Naoko, Furumoto, Yasuko, Villarroel, Vadim A., Linton, Jay T., Tsai, Wanxia L., Gutermuth, Jan, Ghoreschi, Kamran, Gadina, Massimo, O'Shea, John J., Katz, Stephen I.

“…The utility of allogeneic hematopoietic stem cell transplantation is limited by graft-versus-host disease (GVHD), a significant cause of morbidity and…”
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PD-1 regulates autoimmune CD8 T cell-mediated mucocutaneous disease of ‘interface dermatitis’ via PD-L1 expressed on target epidermal cells by Okiyama, Naoko, Katz, Stephen I

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The use of mouse models to better understand mechanisms of autoimmunity and tolerance by Miyagawa, Fumi, Gutermuth, Jan, Zhang, Hong, Katz, Stephen I

“…Abstract A major emphasis of our studies has been on developing a better understanding of how and why the skin serves as a target for immune reactions as well…”
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Identification of CD3+CD4−CD8− T Cells as Potential Regulatory Cells in an Experimental Murine Model of Graft-Versus-Host Skin Disease (GVHD) by Miyagawa, Fumi, Okiyama, Naoko, Villarroel, Vadim, Katz, Stephen I.

“…We have developed K14-mOVA transgenic (Tg) mice that express membrane-associated ovalbumin (mOVA) under the control of a K14 promoter, as well as double Tg…”
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CXCR3-Mediated Skin Homing of Autoreactive CD8 T Cells Is a Key Determinant in Murine Graft-Versus-Host Disease by Villarroel, Vadim A., Okiyama, Naoko, Tsuji, Gaku, Linton, Jay T., Katz, Stephen I.

“…The pathomechanisms underlying the development of cutaneous graft-versus-host disease (GVHD) are incompletely defined. We previously reported that K14-mOVA…”
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Activation through CD40 ligation induces functional Fas ligand expression by Langerhans cells by Shibaki, Akihiko, Katz, Stephen I.

“…Langerhans cells (LC) are professional antigen‐presenting cells of dendritic cell (DC) lineage and are critical for the induction of primary immune responses…”
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Training at the NIAMS: Ensuring a Vibrant Future for Musculoskeletal Research by Katz, Stephen I

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Wolfram Sterry: Physician - Scientist - Cosmopolitan by Stingl, Georg, Katz, Stephen I.

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The current status of investigative dermatology II by Katz, Stephen I.

“…:  Major advances in skin biology and skin diseases are heralding new and more specific forms of treatment that are based on better characterization of…”
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