Search Results - "Katz, Jonathan P."

Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma by Natsuizaka, Mitsuteru, Whelan, Kelly A., Kagawa, Shingo, Tanaka, Koji, Giroux, Veronique, Chandramouleeswaran, Prasanna M., Long, Apple, Sahu, Varun, Darling, Douglas S., Que, Jianwen, Yang, Yizeng, Katz, Jonathan P., Wileyto, E. Paul, Basu, Devraj, Kita, Yoshiaki, Natsugoe, Shoji, Naganuma, Seiji, Klein-Szanto, Andres J., Diehl, J. Alan, Bass, Adam J., Wong, Kwok-Kin, Rustgi, Anil K., Nakagawa, Hiroshi

“…Notch1 transactivates Notch3 to drive terminal differentiation in stratified squamous epithelia. Notch1 and other Notch receptor paralogs cooperate to act as a…”
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WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation by Xu, Mingang, Horrell, Jeremy, Snitow, Melinda, Cui, Jiawei, Gochnauer, Heather, Syrett, Camille M., Kallish, Staci, Seykora, John T., Liu, Fei, Gaillard, Dany, Katz, Jonathan P., Kaestner, Klaus H., Levin, Brooke, Mansfield, Corinne, Douglas, Jennifer E., Cowart, Beverly J., Tordoff, Michael, Liu, Fang, Zhu, Xuming, Barlow, Linda A., Rubin, Adam I., McGrath, John A., Morrisey, Edward E., Chu, Emily Y., Millar, Sarah E.

“…Human WNT10A mutations are associated with developmental tooth abnormalities and adolescent onset of a broad range of ectodermal defects. Here we show that…”
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KLF4 Initiates Acinar Cell Reprogramming and Is Essential for the Early Stages of Pancreatic Carcinogenesis by Maddipati, Ravikanth, Katz, Jonathan P.

“…Pancreatic ductal adenocarcinoma (PDA) has a dismal prognosis and is minimally responsive to current chemotherapies. In this issue of Cancer Cell, Xie et al…”
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HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity by Szigety, Katherine M, Liu, Fang, Yuan, Chase Y, Moran, Deborah J, Horrell, Jeremy, Gochnauer, Heather R, Cohen, Ronald N, Katz, Jonathan P, Kaestner, Klaus H, Seykora, John T, Tobias, John W, Lazar, Mitchell A, Xu, Mingang, Millar, Sarah E

“…Chromatin modifiers play critical roles in epidermal development, but the functions of histone deacetylases in this context are poorly understood. The class I…”
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Deletion of p120-Catenin Results in a Tumor Microenvironment with Inflammation and Cancer that Establishes It as a Tumor Suppressor Gene by Stairs, Douglas B., Bayne, Lauren J., Rhoades, Ben, Vega, Maria E., Waldron, Todd J., Kalabis, Jiri, Klein-Szanto, Andres, Lee, Ju-Seog, Katz, Jonathan P., Diehl, J. Alan, Reynolds, Albert B., Vonderheide, Robert H., Rustgi, Anil K.

“…p120-catenin (p120ctn) interacts with E-cadherin, but to our knowledge, no formal proof that p120ctn functions as a bona fide tumor suppressor gene has emerged…”
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KLF4 activates NFκB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF by Shaverdashvili, Khvaramze, Padlo, Jennie, Weinblatt, Daniel, Jia, Yang, Jiang, Wenpeng, Rao, Divya, Laczkó, Dorottya, Whelan, Kelly A, Lynch, John P, Muir, Amanda B, Katz, Jonathan P

“…Understanding the regulatory mechanisms within esophageal epithelia is essential to gain insight into the pathogenesis of esophageal diseases, which are among…”
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Neutrophils in Cancer and Potential Therapeutic Strategies Using Neutrophil-Derived Exosomes by Dutta, Abhishek, Bhagat, Shrikrishna, Paul, Swastika, Katz, Jonathan P, Sengupta, Debomita, Bhargava, Dharmendra

“…Neutrophils are the most abundant immune cells and make up about 70% of white blood cells in human blood and play a critical role as the first line of defense…”
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Restoring KLF5 in Esophageal Squamous Cell Cancer Cells Activates the JNK Pathway Leading to Apoptosis and Reduced Cell Survival by Tarapore, Rohinton S, Yang, Yizeng, Katz, Jonathan P

“…Abstract Esophageal cancer is the eighth most common cancer in the world and has an extremely dismal prognosis, with a 5-year survival of less than 20%…”
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The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation by Feinberg, Mark W, Wara, Akm Khyrul, Cao, Zhuoxiao, Lebedeva, Maria A, Rosenbauer, Frank, Iwasaki, Hiromi, Hirai, Hideyo, Katz, Jonathan P, Haspel, Richard L, Gray, Susan, Akashi, Koichi, Segre, Julie, Kaestner, Klaus H, Tenen, Daniel G, Jain, Mukesh K

“…Monocyte differentiation involves the participation of lineage‐restricted transcription factors, although the mechanisms by which this process occurs are…”
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KLF5 and p53 comprise an incoherent feed-forward loop directing cell-fate decisions following stress by Yang, Yizeng, Bhargava, Dharmendra, Chen, Xiao, Zhou, Taicheng, Dursuk, Gizem, Jiang, Wenpeng, Wang, Jinshen, Zong, Zhen, Katz, Sharyn I., Lomberk, Gwen A., Urrutia, Raul A., Katz, Jonathan P.

“…In response to stress, cells make a critical decision to arrest or undergo apoptosis, mediated in large part by the tumor suppressor p53. Yet the mechanisms of…”
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All‐Trans Retinoic Acid Promotes a Tumor Suppressive OTUD6B‐β‐TrCP‐SNAIL Axis in Esophageal Squamous Cell Carcinoma and Enhances Immunotherapy by Li, Lei, Zhu, Rui, Zhou, Honghong, Cui, Chun‐Ping, Yu, Xiao, Liu, Yuhao, Yin, Yin, Li, Yang, Feng, Riyue, Katz, Jonathan P., Zhao, Yahui, Zhang, Yun, Zhang, Lingqiang, Liu, Zhihua

“…β‐TrCP is an E3 ubiquitin ligase that plays important roles in multiple human cancers including esophageal squamous cell carcinoma (ESCC). Analysis of ESCC…”
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NOTCH1 and NOTCH3 Coordinate Esophageal Squamous Differentiation Through a CSL-Dependent Transcriptional Network by Ohashi, Shinya, Natsuizaka, Mitsuteru, Yashiro–Ohtani, Yumi, Kalman, Ross A, Nakagawa, Momo, Wu, Lizi, Klein–Szanto, Andres J, Herlyn, Meenhard, Diehl, J. Alan, Katz, Jonathan P, Pear, Warren S, Seykora, John T, Nakagawa, Hiroshi

“…Background & Aims The Notch receptor family regulates cell fate through cell-cell communication. CSL ( C BF-1/RBP-jκ, S u(H), L ag-1) drives canonical…”
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KLF4 transcriptionally activates non-canonical WNT5A to control epithelial stratification by Tetreault, Marie-Pier, Weinblatt, Daniel, Shaverdashvili, Khvaramze, Yang, Yizeng, Katz, Jonathan P.

“…Epithelial differentiation and stratification are essential for normal homeostasis, and disruption of these processes leads to both injury and cancer. The…”
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Krüppel-like factor 5 protects against murine colitis and activates JAK-STAT signaling in vivo by Tetreault, Marie-Pier, Alrabaa, Rami, McGeehan, Megan, Katz, Jonathan P

“…Inflammatory bowel disease (IBD), which is characterized by chronic or recurring inflammation of the gastrointestinal tract, affects 1.4 million persons in the…”
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The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon by Katz, Jonathan P, Perreault, Nathalie, Goldstein, Bree G, Lee, Catherine S, Labosky, Patricia A, Yang, Vincent W, Kaestner, Klaus H

“…Klf4 (formerly GKLF) is a zinc-finger transcription factor expressed in the epithelia of the skin, lungs, gastrointestinal tract and several other organs. In…”
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Krüppel-like factors in cancer by Tetreault, Marie-Pier, Yang, Yizeng, Katz, Jonathan P.

“…Key Points The Krüppel-like factors (KLFs) are a family of transcriptional regulators linked by a triple zinc finger DNA-binding domain. In normal tissues,…”
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Conditional Deletion of the Mouse Klf4 Gene Results in Corneal Epithelial Fragility, Stromal Edema, and Loss of Conjunctival Goblet Cells by Swamynathan, Shivalingappa K., Katz, Jonathan P., Kaestner, Klaus H., Ashery-Padan, Ruth, Crawford, Mary A., Piatigorsky, Joram

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach by Katz, Jonathan P., Perreault, Nathalie, Goldstein, Bree G., Actman, Lori, McNally, Sara R., Silberg, Debra G., Furth, Emma E., Kaestner, Klaus H.

“…Background & Aims: The epithelial zinc-finger transcription factor Klf4 (formerly GKLF) regulates cellular proliferation and differentiation in vitro. Klf4…”
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Loss of Transcription Factor KLF5 in the Context of p53 Ablation Drives Invasive Progression of Human Squamous Cell Cancer by YIZENG YANG, NAKAGAWA, Hiroshi, TETREAULT, Marie-Pier, BILLIG, Janelle, VICTOR, Noel, GOYAL, Abha, SEPULVEDA, Antonia R, KATZ, Jonathan P

“…Squamous cell cancers account for more than half of all human cancers, and esophageal cancer is the sixth leading cause of cancer death worldwide. The majority…”
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p53 mutation alters the effect of the esophageal tumor suppressor KLF5 on keratinocyte proliferation by Yang, Yizeng, Tarapore, Rohinton S., Jarmel, Melissa H., Tetreault, Marie-Pier, Katz, Jonathan P.

“…Krüppel-like factor 5 (KLF5) is a key transcriptional regulator that is typically pro-proliferative in non-transformed epithelial cells but inhibits…”
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