Search Results - "Katz, Ben Zion"

Pursuing the elusive footsteps of malaria in peripheral blood smears utilizing artificial intelligence by Katz, Ben‐Zion, Karny, Shahar

“…For over a century, the need to identify malaria in the peripheral blood has been the driving force behind the development of fundamental clinical microscopy…”
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Differential diagnosis of malignant mononuclear cells in the cerebrospinal fluid: Merkel carcinoma cells by Benisty, Dan, Kay, Sigi, Rund, Deborah, Katz, Ben‐Zion

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Evaluation of Scopio Labs X100 Full Field PBS: The first high‐resolution full field viewing of peripheral blood specimens combined with artificial intelligence‐based morphological analysis by Katz, Ben‐Zion, Feldman, Michael D., Tessema, Minychel, Benisty, Dan, Toles, Grace Stewart, Andre, Alicia, Shtreker, Bronka, Paz, Fatima Maria, Edwards, Joshua, Jengehino, Darrin, Bagg, Adam, Avivi, Irit, Pozdnyakova, Olga

“…Background Current digital cell imaging systems perform peripheral blood smear (PBS) analysis in limited regions of the PBS and require the support of manual…”
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Lymphocyte activation gene 3: a novel therapeutic target in chronic lymphocytic leukemia by Shapiro, Mika, Herishanu, Yair, Katz, Ben-Zion, Dezorella, Nili, Sun, Clare, Kay, Sigi, Polliack, Aaron, Avivi, Irit, Wiestner, Adrian, Perry, Chava

“…A novel therapeutic approach in cancer, attempting to stimulate host anti-tumor immunity, involves blocking of immune checkpoints. Lymphocyte activation gene 3…”
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Spatial organization and early signaling of the B-cell receptor in CLL by Shorer Arbel, Yamit, Bronstein, Yotam, Dadosh, Tali, Kamdjou, Talia, Tsuriel, Shlomo, Shapiro, Mika, Katz, Ben-Zion, Herishanu, Yair

“…Most chronic lymphocytic leukemia (CLL) clones express B-cell receptors (BcR) of both IgM/IgD isotypes; however, 5%–10% of CLL cases express isotype-switched…”
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Fragility of sub-cellular structures in chronic lymphocytic leukemia by Katz, Ben-Zion, Herishanu, Yair

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Proteolysis Targeting Chimeras for BTK Efficiently Inhibit B-Cell Receptor Signaling and Can Overcome Ibrutinib Resistance in CLL Cells by Shorer Arbel, Yamit, Katz, Ben-Zion, Gabizon, Ronen, Shraga, Amit, Bronstein, Yotam, Kamdjou, Talia, Globerson Levin, Anat, Perry, Chava, Avivi, Irit, London, Nir, Herishanu, Yair

“…Proteolysis targeting chimeras (PROTACs) are small molecules that form ternary complexes between their target and E3 ligase, resulting in ubiquitination and…”
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Low FXIII activity levels in intensive care unit hospitalized COVID-19 patients by Lichter, Yael, Badelbayov, Tanya, Shalev, Irina, Schvartz, Reut, Szekely, Yishay, Benisty, Dan, Goldiner, Ilana, Kagarlyk, Maxim, Asraf, Keren, Doolman, Ram, Luttwak, Efrat, Kirgner, Ilya, Avivi, Irit, Adi, Nimrod, Katz, Ben-Zion

“…Abstract Background COVID-19 infection is associated with a hypercoagulable state. Severe COVID-19 patients present with high plasma fibrinogen levels,…”
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SLP76 integrates into the B-cell receptor signaling cascade in chronic lymphocytic leukemia cells and is associated with an aggressive disease course by Dezorella, Nili, Katz, Ben-Zion, Shapiro, Mika, Polliack, Aaron, Perry, Chava, Herishanu, Yair

“…I In the last decade, the B-cell receptor has emerged as a pivotal stimulus in the pathogenesis of chronic lymphocytic leukemia, and a very feasible…”
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Measurement of lymphocyte aggregation by flow cytometry-physiological implications in chronic lymphocytic leukemia by Dezorella, Nili, Kay, Sigi, Baron, Shoshana, Shapiro, Mika, Porat, Ziv, Deutsch, Varda, Herishanu, Yair, Katz, Ben-Zion

“…Background Cellular aggregation is a physiological response of lymphocytes to various extracellular stimuli. Currently, lymphocytes aggregation is only…”
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Daratumumab in combination with proteasome inhibitors, rapidly decreases polyclonal immunoglobulins and increases infection risk among relapsed multiple myeloma patients: a single center retrospective study by Vitkon, Roy, Netanely, Dan, Levi, Shai, Ziv-Baran, Tomer, Ben-Yzak, Ronit, Katz, Ben-Zion, Benyamini, Noam, Trestman, Svetlana, Mittelman, Moshe, Cohen, Yael, Avivi, Irit

“…Background: Daratumumab (Dara) is generally well tolerated, but is associated with increased risk of infection. Methods: We investigated hypogammaglobinemia…”
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Comparing Intraperitoneal and Intravenous Personalized ErbB2CAR-T for the Treatment of Epithelial Ovarian Cancer by Deshet-Unger, Naamit, Horn, Galit, Rawet-Slobodkin, Moran, Waks, Tova, Laskov, Ido, Michaan, Nadav, Raz, Yael, Bar, Vered, Zundelevich, Adi, Aharon, Sara, Turovsky, Lubov, Mallel, Giuseppe, Salpeter, Seth, Neev, Guy, Hollander, Kenneth Samuel, Katz, Ben-Zion, Grisaru, Dan, Globerson Levin, Anat

“…High-grade serous ovarian carcinoma (HGSOC) is the most common type of epithelial ovarian cancer. The majority of cases are diagnosed at advanced stages, when…”
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Shear flow-induced formation of tubular cell protrusions in multiple myeloma cells by Porat, Ziv, Yaron, Itamar, Katz, Ben-Zion, Kam, Zvi, Geiger, Benjamin

“…Exposure of live cells to shear flow induces major changes in cell shape, adhesion to the extracellular matrix, and migration. In the present study, we show…”
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Physical state of the extracellular matrix regulates the structure and molecular composition of cell-matrix adhesions by Katz, B Z, Zamir, E, Bershadsky, A, Kam, Z, Yamada, K M, Geiger, B

“…This study establishes that the physical state of the extracellular matrix can regulate integrin-mediated cytoskeletal assembly and tyrosine phosphorylation to…”
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Dynamics and segregation of cell-matrix adhesions in cultured fibroblasts by Zamir, Eli, Katz, Menachem, Posen, Yehudit, Erez, Noam, Yamada, Kenneth M, Katz, Ben-Zion, Lin, Shin, Lin, Diane C, Bershadsky, Alexander, Kam, Zvi, Geiger, Benjamin

“…Here we use time-lapse microscopy to analyse cell-matrix adhesions in cells expressing one of two different cytoskeletal proteins, paxillin or tensin, tagged…”
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Efficient Targeted Degradation via Reversible and Irreversible Covalent PROTACs by Gabizon, Ronen, Shraga, Amit, Gehrtz, Paul, Livnah, Ella, Shorer, Yamit, Gurwicz, Neta, Avram, Liat, Unger, Tamar, Aharoni, Hila, Albeck, Shira, Brandis, Alexander, Shulman, Ziv, Katz, Ben-Zion, Herishanu, Yair, London, Nir

“…Proteolysis targeting chimeras (PROTACs) represent an exciting inhibitory modality with many advantages, including substoichiometric degradation of targets…”
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Mimicking the haematopoietic niche microenvironment provides a novel strategy for expansion of haematopoietic and megakaryocyte‐progenitor cells from cord blood by Deutsch, Varda, Hubel, Einav, Kay, Sigi, Ohayon, Tal, Katz, Ben‐Zion, Many, Ariel, Zander, Axel, Naparstek, Elizabeth, Grisaru, Dan

“…Summary Severe neutropenia and protracted thrombocytopenia remain serious clinical problems following cord blood transplantation (CBT) due to the paucity of…”
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Heparanase, heparin and the coagulation system in cancer progression by Vlodavsky, Israel, Ilan, Neta, Nadir, Yona, Brenner, Benjamin, Katz, Ben-Zion, Naggi, Annamaria, Torri, Giangiacomo, Casu, Benito, Sasisekharan, Ram

“…Abstract Heparanase is an endoglycosidase which cleaves heparan sulfate (HS) and hence participates in degradation and remodeling of the extracellular matrix…”
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Adhesion molecules—The lifelines of multiple myeloma cells by Katz, Ben-Zion

“…Abstract Multiple myeloma is an incurable hematological malignancy of terminally differentiated immunoglobulin-producing plasma cells. As a common presentation…”
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Therapeutic targeting of CD19 in hematological malignancies: past, present, future and beyond by Katz, Ben-Zion, Herishanu, Yair

“…Abstract During the past few decades, CD19 has been at the center of various scientific/translational endeavors to develop targeted therapeutics against B-cell…”
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