Search Results - "Katunuma, N"

Invasiveness of transformed human breast epithelial cell lines is related to cathepsin B and inhibited by cysteine proteinase inhibitors by Bervar, Ales, Zajc, Irena, Sever, Natasa, Katunuma, Nobuhiko, Sloane, Bonnie F, Lah, Tamara T

“…The activities'of the lysosomal cysteine proteinases cathepsin B and L are regulated by their endogenous inhibitors, stefins A and B, and cystatin C, and their…”
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Detection of protease inhibitors by a reverse zymography method, performed in a tris(hydroxymethyl)aminomethane–Tricine buffer system by Le, Q.T, Katunuma, N

“…A new detecting method for protease inhibitors, especially for low-molecular-weight inhibitors, is reported. Inhibitor samples were separated on a protein…”
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The refined 2.15 A X‐ray crystal structure of human liver cathepsin B: the structural basis for its specificity by Musil, D., Zucic, D., Turk, D., Engh, R.A., Mayr, I., Huber, R., Popovic, T., Turk, V., Towatari, T., Katunuma, N.

“…From the lysosomal cysteine proteinase cathepsin B, isolated from human liver in its two‐chain form, monoclinic crystals were obtained which contain two…”
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Insights into the roles of cathepsins in antigen processing and presentation revealed by specific inhibitors by Katunuma, Nobuhiko, Matsunaga, Yoichi, Himeno, Kunisuke, Hayashi, Yoshio

“…Eleven human cathepsins have been identified, however, the in vivo roles of individual cathepsins are still largely unknown. In this brief review we will…”
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New functions of lactoferrin and β-casein in mammalian milk as cysteine protease inhibitors by Ohashi, A, Murata, E, Yamamoto, K, Majima, E, Sano, E, Le, Q.T, Katunuma, N

“…We found new inhibitory function of lactoferrin and β-casein in milk against cysteine proteases using reverse zymography. The inhibition of cathepsin L by…”
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Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivo by Katunuma, N., Murata, E., Kakegawa, H., Matsui, A., Tsuzuki, H., Tsuge, H., Turk, D., Turk, V., Fukushima, M., Tada, Y., Asao, T.

“…Specific inhibitors for cathepsin L and cathepsin S have been developed with the help of computer-graphic modeling based on the stereo-structure. The common…”
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Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: A basis for the design of specific epoxysuccinyl inhibitors by Turk, D, Podobnik, M, Popovic, T, Katunuma, N, Bode, W, Huber, R, Turk, V

“…Crystals of cysteine protease human cathepsin B inhibited with CA030 (ethyl ester of epoxysuccinyl-Ile-Pro-OH) [Murata, M., et al. (1991) FEBS Lett. 280,…”
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Double-layer fluorescent zymography for processing protease detection by Katunuma, N., Le, Q.T., Miyauchi, R., Hirose, S.

“…We have developed a novel double-layer zymographic method for the detection of specific processing proteases of a target proprotease using a specific…”
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Structure-Based Design of Specific Cathepsin Inhibitors and Their Application to Protection of Bone Metastases of Cancer Cells by Katunuma, N., Tsuge, H., Nukatsuka, M., Asao, T., Fukushima, M.

“…We report the antihypercalcemic and antimetastatic effects of CLIK-148 in vivo, which is a specific inhibitor of cathepsin L. The decalcification during bone…”
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Lysosomal cathepsin B plays an important role in antigen processing, while cathepsin D is involved in degradation of the invariant chain in
ovalbumin‐immunized mice by Zhang, T., Maekawa, Y., Hanba, J., Dainichi, T., Nashed, B. F., Hisaeda, H., Sakai, T, Asao, T, Himeno, K., Good, R. A., Katunuma, N.

“…Summary We previously reported that CA074, a specific inhibitor of cathepsin B, modulates specific immune responses from the T helper 2 (Th2) type to Th1 type…”
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Structure-Based Development of Pyridoxal Propionate Derivatives as Specific Inhibitors of Cathepsin K in Vitro and in Vivo by Katunuma, N., Matsui, A., Inubushi, T., Murata, E., Kakegawa, H., Ohba, Y., Turk, D., Turk, V., Tada, Y., Asao, T.

“…We found that pyridoxal phosphate shows considerable inhibition of cathepsins. CLIK-071, in which the phosphate ester of position 3 of pyridoxal phosphate was…”
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Isolation and characterization of a novel trypsin-like protease found in rat bronchiolar epithelial Clara cells. A possible activator of the viral fusion glycoprotein by KIDO, H, YOKOGOSHI, Y, SAKAI, K, TASHIRO, M, KISHINO, Y, FUKUTOMI, A, KATUNUMA, N

“…A novel trypsin-like protease associated with rat bronchiolar epithelial Clara cells, named Tryptase Clara, was purified to homogeneity from rat lung by a…”
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Invasion of ras-transformed breast epithelial cells depends on the proteolytic activity of cysteine and aspartic proteinases by Premzl, A, Puizdar, V, Zavasnik-Bergant, V, Kopitar-Jerala, N, Lah, T T, Katunuma, N, Sloane, B F, Turk, V, Kos, J

“…It has been suggested that the lysosomal proteinases cathepsin B, L and D participate in tumour invasion and metastasis. Whereas for cathepsins B and L the…”
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Isolation and characterization of a novel and potent inhibitor of Arg-gingipain from Streptomyces sp. strain FA-70 by Kadowaki, Tomoko, Kitano, Shizuo, Baba, Atsuyo, Takii, Ryosuke, Hashimoto, Munetaka, Katunuma, Nobuhiko, Yamamoto, Kenji

“…Arg-gingipain (Rgp) is a major cysteine proteinase produced by the oral bacterium Porphyromonas gingivalis, which is a major pathogen of advanced periodontal…”
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Chondroitin sulfate proteoglycan is a potent enhancer in the processing of procathepsin L by Kihara, Motohiro, Kakegawa, Hisao, Matano, Yuko, Murata, Etsuko, Tsuge, Hideaki, Kido, Hiroshi, Katunuma, Nobuhiko

“…The acceleration effect of chondroitin-4-sulfate(CS-) proteoglycan on the processing of procathepsin L in vitro was investigated using enzyme purified from the…”
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Kunitz-type protease inhibitor found in rat mast cells. Purification, properties, and amino acid sequence by Kido, H, Yokogoshi, Y, Katunuma, N

“…A low molecular weight serine protease inhibitor, named trypstatin, was purified from rat peritoneal mast cells. It is a single polypeptide with 61 amino acid…”
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Processing protease for gp160 human immunodeficiency virus type I envelope glycoprotein precursor in human T4+ lymphocytes. Purification and characterization by Kido, H, Kamoshita, K, Fukutomi, A, Katunuma, N

“…A processing protease for the human immunodeficiency virus type I (HIV-I) envelope glycoprotein gp160 precursor has been purified to homogeneity from the…”
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Effect of dietary vitamin B6 contents on antibody production by Inubushi, T., Okada, M., Matsui, A., Hanba, J., Murata, E., Katunuma, N.

“…When mice were placed on diets extreme deficient in vitamin B6, ovalbumin‐dependent antibody productions (IgE, IgG1, IgG2a) were significantly suppressed, and…”
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Nomenclature and classification of the proteins homologous with the cysteine-proteinase inhibitor chicken cystatin by Barrett, A J, Fritz, H, Grubb, A, Isemura, S, Järvinen, M, Katunuma, N, Machleidt, W, Müller-Esterl, W, Sasaki, M, Turk, V

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A novel membrane-bound serine esterase in human T4+ lymphocytes immunologically reactive with antibody inhibiting syncytia induced by HIV-1. Purification and characterization by Kido, H, Fukutomi, A, Katunuma, N

“…A novel membrane-bound serine esterase, named tryptase TL2, which is immunologically reactive with the antibody inhibiting induction of syncytia by human…”
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