Search Results - "Katti, Alyna"

CRISPR in cancer biology and therapy by Katti, Alyna, Diaz, Bianca J., Caragine, Christina M., Sanjana, Neville E., Dow, Lukas E.

“…Over the past decade, CRISPR has become as much a verb as it is an acronym, transforming biomedical research and providing entirely new approaches for…”
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Base editing goes into hyperdrive by Katti, Alyna, Dow, Lukas E.

“…CRISPR base editors can induce single-base-pair changes in the genome, although they are often inefficient. A study now shows that fusion of the DNA-binding…”
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Optimized base editors enable efficient editing in cells, organoids and mice by Zafra, Maria Paz, Schatoff, Emma M, Katti, Alyna, Foronda, Miguel, Breinig, Marco, Schweitzer, Anabel Y, Simon, Amber, Han, Teng, Goswami, Sukanya, Montgomery, Emma, Thibado, Jordana, Kastenhuber, Edward R, Sánchez-Rivera, Francisco J, Shi, Junwei, Vakoc, Christopher R, Lowe, Scott W, Tschaharganeh, Darjus F, Dow, Lukas E

“…The efficiency of base editing is substantially increased by optimizing expression and nuclear localization of the editing enzymes. CRISPR base editing enables…”
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Dietary fructose improves intestinal cell survival and nutrient absorption by Taylor, Samuel R., Ramsamooj, Shakti, Liang, Roger J., Katti, Alyna, Pozovskiy, Rita, Vasan, Neil, Hwang, Seo-Kyoung, Nahiyaan, Navid, Francoeur, Nancy J., Schatoff, Emma M., Johnson, Jared L., Shah, Manish A., Dannenberg, Andrew J., Sebra, Robert P., Dow, Lukas E., Cantley, Lewis C., Rhee, Kyu Y., Goncalves, Marcus D.

“…Fructose consumption is linked to the rising incidence of obesity and cancer, which are two of the leading causes of morbidity and mortality globally 1 , 2 …”
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Strategies to Improve the Engineering of Cancer Associated SNVs with Base Editing by Katti, Alyna

“…Base editing (BE) is a powerful tool for engineering single nucleotide variants (SNVs) and has been used to create targeted mutations in cell lines, organoids,…”
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GO: a functional reporter system to identify and enrich base editing activity by Katti, Alyna, Foronda, Miguel, Zimmerman, Jill, Diaz, Bianca, Zafra, Maria Paz, Goswami, Sukanya, Dow, Lukas E

“…Abstract Base editing (BE) is a powerful tool for engineering single nucleotide variants (SNVs) and has been used to create targeted mutations in cell lines,…”
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Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants by Sánchez-Rivera, Francisco J., Diaz, Bianca J., Kastenhuber, Edward R., Schmidt, Henri, Katti, Alyna, Kennedy, Margaret, Tem, Vincent, Ho, Yu-Jui, Leibold, Josef, Paffenholz, Stella V., Barriga, Francisco M., Chu, Kevan, Goswami, Sukanya, Wuest, Alexandra N., Simon, Janelle M., Tsanov, Kaloyan M., Chakravarty, Debyani, Zhang, Hongxin, Leslie, Christina S., Lowe, Scott W., Dow, Lukas E.

“…Base editing can be applied to characterize single nucleotide variants of unknown function, yet defining effective combinations of single guide RNAs (sgRNAs)…”
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Abstract PHA05: Strategies to improve engineering cancer-associated SNVs with base editing by Katti, Alyna, Foronda, Miguel, Zimmerman, Jill, Diaz, Bianca, Zafra, Maria Paz, Goswami, Sukanya, Piskounova, Elena, Dow, Lukas E.

“…Abstract Base editing (BE) is a powerful tool for engineering single-nucleotide variants (SNVs) and has been used to create targeted mutations in cell lines,…”
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Generation of precision preclinical cancer models using regulated in vivo base editing by Katti, Alyna, Vega-Pérez, Adrián, Foronda, Miguel, Zimmerman, Jill, Zafra, Maria Paz, Granowsky, Elizabeth, Goswami, Sukanya, Gardner, Eric E., Diaz, Bianca J., Simon, Janelle M., Wuest, Alexandra, Luan, Wei, Fernandez, Maria Teresa Calvo, Kadina, Anastasia P., Walker, John A., Holden, Kevin, Lowe, Scott W., Sánchez Rivera, Francisco J., Dow, Lukas E.

“…Although single-nucleotide variants (SNVs) make up the majority of cancer-associated genetic changes and have been comprehensively catalogued, little is known…”
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Functional Common and Rare ERBB2 Germline Variants Cooperate in Familial and Sporadic Cancer Susceptibility by Bao, Riyue, Ng, Anita, Sasaki, Mark, Esai Selvan, Myvizhi, Katti, Alyna, Lee, Hyesan, Huang, Lei, Skol, Andrew D, Lavarino, Cinzia, Salvador, Hector, Klein, Robert J, Gümüş, Zeynep H, Mora, Jaume, Onel, Kenan

“…We investigated a Spanish and Catalan family in which multiple cancer types tracked across three generations, but for which no genetic etiology had been…”
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