Analysis of anti-obesity and anti-diabetic effects of acacia bark-derived proanthocyanidins in type 2 diabetes model KKAy mice

Analysis of anti-obesity and anti-diabetic effects of acacia bark-derived proanthocyanidins in type 2 diabetes model KKAy mice

The acacia bark extract derived from Acacia mearnsii De Wild is rich in proanthocyanidins, whose constituent units are robinetinidol, fisetinidol, catechin, and gallocatechin. In this study, we examined the effect of proanthocyanidins on obesity and diabetes using KKAy mice, a type 2 diabetes model....

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Bibliographic Details
Published in:Journal of natural medicines Vol. 75; no. 4; pp. 893 - 906
Main Authors: Kashiwada, Mayumi, Nakaishi, Saho, Usuda, Ayumi, Miyahara, Yumi, Katsumoto, Kenta, Katsura, Kyoko, Terakado, Izumi, Jindo, Makiko, Nakajima, Shihori, Ogawa, Sosuke, Sugiyama, Kiyoshi, Ochiai, Wataru
Format: Journal Article
Language:English
Published: Singapore Springer Singapore 01-09-2021
Springer Nature B.V
Subjects:
Adiponectin
Adipose tissue
Antidiabetics
Bark
Biological products
Biomedical and Life Sciences
Biomedicine
Blood glucose
Body weight
Body weight gain
Catechin
Complementary & Alternative Medicine
Diabetes
Diabetes mellitus (non-insulin dependent)
Diet
Fasting
Gluconeogenesis
High fat diet
Insulin
Laboratory testing
Low fat diet
Medicinal Chemistry
Nutrient deficiency
Obesity
Original Paper
Pharmacology/Toxicology
Pharmacy
Plant extracts
Plant Sciences
Proanthocyanidins
Skeletal muscle
Obesity
Proanthocyanidin
Acacia bark
KKAy mouse
Diabetes
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Summary:The acacia bark extract derived from Acacia mearnsii De Wild is rich in proanthocyanidins, whose constituent units are robinetinidol, fisetinidol, catechin, and gallocatechin. In this study, we examined the effect of proanthocyanidins on obesity and diabetes using KKAy mice, a type 2 diabetes model. KKAy mice were fed either a low-fat diet, a high-fat diet, or a high-fat diet mixed with an acacia bark extract, a proanthocyanidins fraction, and other fraction for 7 weeks. Monitoring the changes in the body weight revealed that acacia bark extract and proanthocyanidins fraction could prevent excessive weight gain resulting from a high-fat diet. In addition, increases in the fasting blood glucose level due to high-fat diet intake were found to be suppressed by acacia bark extract and proanthocyanidins fraction. Furthermore, proanthocyanidins derived from acacia bark were found to increase the expression of adiponectin in white adipose tissue, which enhances the action of insulin. In addition, acacia bark-derived proanthocyanidins suppressed gluconeogenesis and fatty acid synthesis in the liver, as well as suppressing the decrease in energy production under pathological conditions in skeletal muscle. In addition, acacia bark-derived proanthocyanidins showed AMPK activation and DPP-4 inhibitory action. Therefore, it was suggested that acacia bark-derived proanthocyanidins lowered fasting blood glucose levels through the above mechanism. These results suggest that proanthocyanidins derived from acacia bark are the active ingredients of the anti-obesity and anti-diabetic effects of acacia bark extract. Graphic abstract
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-021-01537-7