Search Results - "Katsumura, Koichi R."

The GATA factor revolution in hematology by Katsumura, Koichi R., Bresnick, Emery H.

“…The discovery of the GATA binding protein (GATA factor) transcription factor family revolutionized hematology. Studies of GATA proteins have yielded vital…”
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GATA Factor-Dependent Positive-Feedback Circuit in Acute Myeloid Leukemia Cells by Katsumura, Koichi R., Ong, Irene M., DeVilbiss, Andrew W., Sanalkumar, Rajendran, Bresnick, Emery H.

“…The master regulatory transcription factor GATA-2 triggers hematopoietic stem and progenitor cell generation. GATA2 haploinsufficiency is implicated in…”
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Human GATA2 mutations and hematologic disease: how many paths to pathogenesis? by Bresnick, Emery H., Jung, Mabel M., Katsumura, Koichi R.

“…The surge of human genetic information, enabled by increasingly facile and economically feasible genomic technologies, has accelerated discoveries on the…”
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Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program by Mehta, Charu, Johnson, Kirby D., Gao, Xin, Ong, Irene M., Katsumura, Koichi R., McIver, Skye C., Ranheim, Erik A., Bresnick, Emery H.

“…Hematopoietic development requires the transcription factor GATA-2, and GATA-2 mutations cause diverse pathologies, including leukemia. GATA-2-regulated…”
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Pathogenic human variant that dislocates GATA2 zinc fingers disrupts hematopoietic gene expression and signaling networks by Jung, Mabel Minji, Shen, Siqi, Botten, Giovanni A, Olender, Thomas, Katsumura, Koichi R, Johnson, Kirby D, Soukup, Alexandra A, Liu, Peng, Zhang, Qingzhou, Jensvold, Zena D, Lewis, Peter W, Beagrie, Robert A, Low, Jason Kk, Yang, Lihua, Mackay, Joel P, Godley, Lucy A, Brand, Marjorie, Xu, Jian, Keles, Sunduz, Bresnick, Emery H

“…Although certain human genetic variants are conspicuously loss of function, decoding the impact of many variants is challenging. Previously, we described a…”
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Molecular basis of crosstalk between oncogenic Ras and the master regulator of hematopoiesis GATA-2 by Katsumura, Koichi R, Yang, Chenxi, Boyer, Meghan E, Li, Lingjun, Bresnick, Emery H

“…Disease mutations provide unique opportunities to decipher protein and cell function. Mutations in the master regulator of hematopoiesis GATA‐2 underlie an…”
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Exosome complex orchestrates developmental signaling to balance proliferation and differentiation during erythropoiesis by McIver, Skye C, Katsumura, Koichi R, Davids, Elsa, Liu, Peng, Kang, Yoon-A, Yang, David, Bresnick, Emery H

“…Since the highly conserved exosome complex mediates the degradation and processing of multiple classes of RNAs, it almost certainly controls diverse biological…”
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Restricting genomic actions of innate immune mediators on fetal hematopoietic progenitor cells by Tran, Vu L., Liu, Peng, Katsumura, Koichi R., Kim, Erin, Schoff, Bjorn M., Johnson, Kirby D., Bresnick, Emery H.

“…Innate immune signaling protects against pathogens, controls hematopoietic development, and functions in oncogenesis, yet the relationship between these…”
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Pathogenic GATA2 genetic variants utilize an obligate enhancer mechanism to distort a multilineage differentiation program by Katsumura, Koichi R, Liu, Peng, Kim, Jeong-Ah, Mehta, Charu, Bresnick, Emery H

“…Mutations in genes encoding transcription factors inactivate or generate ectopic activities to instigate pathogenesis. By disrupting hematopoietic…”
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Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies by Bresnick, Emery H, Katsumura, Koichi R, Lee, Hsiang-Ying, Johnson, Kirby D, Perkins, Archibald S

“…Numerous examples exist of how disrupting the actions of physiological regulators of blood cell development yields hematologic malignancies. The master…”
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Constructing and deconstructing GATA2-regulated cell fate programs to establish developmental trajectories by Johnson, Kirby D, Conn, Daniel J, Shishkova, Evgenia, Katsumura, Koichi R, Liu, Peng, Shen, Siqi, Ranheim, Erik A, Kraus, Sean G, Wang, Weixin, Calvo, Katherine R, Hsu, Amy P, Holland, Steven M, Coon, Joshua J, Keles, Sunduz, Bresnick, Emery H

“…Stem and progenitor cell fate transitions constitute key decision points in organismal development that enable access to a developmental path or actively…”
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Human leukemia mutations corrupt but do not abrogate GATA-2 function by Katsumura, Koichi R., Mehta, Charu, Hewitt, Kyle J., Soukup, Alexandra A., de Andrade, Isabela Fraga, Ranheim, Erik A., Johnson, Kirby D., Bresnick, Emery H.

“…By inducing the generation and function of hematopoietic stem and progenitor cells, the master regulator of hematopoiesis GATA-2 controls the production of all…”
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Breaking the spatial constraint between neighboring zinc fingers: a new germline mutation in GATA2 deficiency syndrome by Cavalcante de Andrade Silva, Marcela, Katsumura, Koichi R., Mehta, Charu, Velloso, Elvira D. R. P., Bresnick, Emery H., Godley, Lucy A.

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GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia by Hewitt, Kyle J., Katsumura, Koichi R., Matson, Daniel R., Devadas, Prithvia, Tanimura, Nobuyuki, Hebert, Alexander S., Coon, Joshua J., Kim, Jin-Soo, Dewey, Colin N., Keles, Sunduz, Hao, Siyang, Paulson, Robert F., Bresnick, Emery H.

“…An enhancer with amalgamated E-box and GATA motifs (+9.5) controls expression of the regulator of hematopoiesis GATA-2. While similar GATA-2-occupied elements…”
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Epigenetic Determinants of Erythropoiesis: Role of the Histone Methyltransferase SetD8 in Promoting Erythroid Cell Maturation and Survival by DeVilbiss, Andrew W., Sanalkumar, Rajendran, Hall, Bryan D. R., Katsumura, Koichi R., de Andrade, Isabela Fraga, Bresnick, Emery H.

“…Erythropoiesis, in which committed progenitor cells generate millions of erythrocytes daily, involves dramatic changes in the chromatin structure and…”
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Transcriptional mechanisms underlying hemoglobin synthesis by Katsumura, Koichi R, DeVilbiss, Andrew W, Pope, Nathaniel J, Johnson, Kirby D, Bresnick, Emery H

“…The physiological switch in expression of the embryonic, fetal, and adult β-like globin genes has garnered enormous attention from investigators interested in…”
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Linking GATA2 Deficiency to Dysregulated Innate Immune Signaling by Tran, Vu L., Johnson, Kirby D., Katsumura, Koichi R., Bresnick, Emery H.

“…Cell type-specific transcription factors governing hematopoietic stem and progenitor cell transitions establish networks containing hundreds of genes and…”
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Spacing Constraints of Neighboring Zinc Finger Modules within GATA2 by Jung, Mabel M., Katsumura, Koichi R., Liu, Peng, Johnson, Kirby D., Mackay, Joel P., Godley, Lucy A., Bresnick, Emery H.

“…Genomic analyses in clinical and experimental contexts have accelerated discoveries of human genetic variants. While elucidating the consequences of…”
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