Search Results - "Katsuhiro Miyajima"

Effects of Siraitia grosvenorii extract on nonalcoholic steatohepatitis-like lesions in Sprague Dawley rats fed a choline-deficient, methionine-lowered, l-amino acid-defined diet by Uno, Kinuko, Miyajima, Katsuhiro, Ogawa, Shuji, Suzuki-Kemuriyama, Noriko, Nakae, Dai

“…Siraitia grosvenorii is the fruit of a cucurbitaceous vine endemic to China. Its extract has been used as a sweetener and exhibits various anti-inflammatory…”
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CD44 expression in the bile duct epithelium is related to hepatic fibrosis in nonalcoholic steatohepatitis rats induced by a choline-deficient, methionine-lowered, L-amino acid diet by Uno, Kinuko, Miyajima, Katsuhiro, Toma, Marika, Suzuki-Kemuriyama, Noriko, Nakae, Dai

“…Nonalcoholic steatohepatitis is a lifestyle-related disease and an increasing threat worldwide. Hepatic fibrosis, which results from chronic hepatic diseases…”
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Effects of salt supplementation in uninephrectomized KK-Ay mice: Examining the potential of a diabetic kidney disease model by Sano, Ryuhei, Ryu, Kanjiro, Sasase, Tomohiko, Shinozaki, Yuichi, Teoh, Soon Hui, Yamaguchi, Ayane, Uno, Kinuko, Maekawa, Tatsuya, Ohta, Takeshi, Miyajima, Katsuhiro

“…Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD). Although current therapeutic strategies for DKD, including sodium-glucose…”
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Effects of excessive sodium chloride loading in the spontaneously diabetic torii (SDT) fatty rats, a preclinical model of type 2 diabetes mellitus by Teoh, Soon Hui, Miyajima, Katsuhiro, Shinozaki, Yuichi, Shinohara, Masami, Ohata, Keiichi, Briand, François, Morimoto, Rika, Nakamura, Yuka, Uno, Kinuko, Kemuriyama, Noriko, Nakae, Dai, Ohta, Takeshi, Maekawa, Tatsuya

“…Type 2 diabetes mellitus represents an international health concern with its growing number of patients worldwide. At the same time, excessive salt consumption…”
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Case analysis of kinetics investigations in toxicity studies of pesticides to identify the nonlinearity of internal exposure and the influences of nonlinearity on the toxicological interpretation of pesticide residue by Machino, Satoshi, Yokoyama, Yoko, Egawa, Toyohiro, Satoh, Hiroshi, Miyajima, Katsuhiro, Yoshida, Midori, Asano, Satoshi, Ozawa, Shogo

“…The nonlinearity of internal exposure to 8 pesticides was investigated in toxicity studies using kinetics to identify nonlinearity visually and to investigate…”
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Diabetic Complications in Obese Type 2 Diabetic Rat Models by Katsuda, Yoshiaki, Ohta, Takeshi, Miyajima, Katsuhiro, Kemmochi, Yusuke, Sasase, Tomohiko, Tong, Bin, Shinohara, Masami, Yamada, Takahisa

“…We overviewed the pathophysiological features of diabetes and its complications in obese type 2 diabetic rat models: Otsuka Long-Evans Tokushima fatty (OLETF)…”
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Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice by Suzuki-Kemuriyama, Noriko, Matsuzaka, Takashi, Kuba, Motoko, Ohno, Hiroshi, Han, Song-Iee, Takeuchi, Yoshinori, Isaka, Masaaki, Kobayashi, Kazuto, Iwasaki, Hitoshi, Yatoh, Shigeru, Suzuki, Hiroaki, Miyajima, Katsuhiro, Nakae, Dai, Yahagi, Naoya, Nakagawa, Yoshimi, Sone, Hirohito, Yamada, Nobuhiro, Shimano, Hitoshi

“…Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, can progress to steatohepatitis (NASH) and advanced liver damage,…”
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Mycotoxin Deoxynivalenol Has Different Impacts on Intestinal Barrier and Stem Cells by Its Route of Exposure by Hanyu, Hikaru, Yokoi, Yuki, Nakamura, Kiminori, Ayabe, Tokiyoshi, Tanaka, Keisuke, Uno, Kinuko, Miyajima, Katsuhiro, Saito, Yuki, Iwatsuki, Ken, Shimizu, Makoto, Tadaishi, Miki, Kobayashi-Hattori, Kazuo

“…The different effects of deoxynivalenol (DON) on intestinal barrier and stem cells by its route of exposure remain less known. We explored the toxic effects of…”
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Correction to: A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a cholinedeficient, methionine-lowered, L-amino acid-defined, high-fat diet by Suzuki-Kemuriyama, Noriko, Abe, Akari, Uno, Kinuko, Ogawa, Shuji, Watanabe, Atsushi, Sano, Ryuhei, Yuki, Megumi, Miyajima, Katsuhiro, Nakae, Dai

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Animal Models of Diabetes and Related Metabolic Diseases by Sasase, Tomohiko, Fatchiyah, Fatchiyah, Miyajima, Katsuhiro, Koide, Masayo

“…In the article entitled “Spontaneously Diabetic Torii (SDT) Fatty Rat, a Novel Animal Model of Type 2 Diabetes Mellitus, Shows Blunted Circadian Rhythms and…”
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A case of spontaneous Zymbal’s gland carcinoma with lung metastasis in an aged Fischer 344 rat by Maeno, Ai, Sakamoto, Yoshimitsu, Hojo, Motoki, Tada, Yukie, Suzuki, Jin, Inomata, Akiko, Moriyasu, Takako, Hirose, Akihiko, Kemuriyama, Noriko, Miyajima, Katsuhiro, Nakae, Dai

“…Zymbal’s gland neoplasms are induced in rats through the administration of various carcinogens, but spontaneous neoplasia is rare. This report describes a…”
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Pathophysiological profiles of SDT fatty rats, a potential new diabetic peripheral neuropathy model by Maekawa, Tatsuya, Tadaki, Hironobu, Sasase, Tomohiko, Motohashi, Yu, Miyajima, Katsuhiro, Ohta, Takeshi, Kume, Shinichi

“…To establish an animal model for diabetic peripheral neuropathy (DPN) at an earlier stage, we performed functional and pathophysiological evaluations in…”
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Impact of altered dietary calcium–phosphorus ratio caused by high-phosphorus diets in a rat chronic kidney disease (CKD) model created by partial ligation of the renal arteries by Watanabe, Atsushi, Koizumi, Toshinori, Horikawa, Takumi, Sano, Yusuke, Uki, Haruka, Miyajima, Katsuhiro, Kemuriyama, Noriko, Anzai, Reo, Iwata, Hijiri, Anzai, Takayuki, Nakagawa, Kenshi, Nakae, Dai

“…This study aimed to establish a rat chronic kidney disease (CKD) model by studying the effects of a high-phosphorus diet in rats that had undergone partial…”
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A histopathological analysis of spontaneous neoplastic and non-neoplastic lesions in aged male RccHan:WIST rats by Hojo, Motoki, Sakamoto, Yoshimitsu, Maeno, Ai, Tayama, Kuniaki, Tada, Yukie, Yuzawa, Katsuhiro, Ando, Hiroshi, Kubo, Yoshikazu, Nagasawa, Akemichi, Tanaka, Kazuyoshi, Yano, Norio, Kaihoko, Fujifumi, Hasegawa, Yuko, Suzuki, Toshinari, Inomata, Akiko, Moriyasu, Takako, Miyajima, Katsuhiro, Nakae, Dai

“…Histopathological information about spontaneous lesions in aged Hannover Wistar rats is limited. In this study, we describe spontaneous lesions found in 39…”
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Investigation of pharmacological responses to anti-diabetic drugs in female Spontaneously Diabetic Torii (SDT) fatty rats, a new nonalcoholic steatohepatitis (NASH) model by TORINIWA, Yasufumi, SAITO, Tomoyuki, MIYAJIMA, Katsuhiro, ISHII, Yukihito, UNO, Kinuko, MAEKAWA, Tatsuya, MATSUI, Tohru, KUME, Shinichi, YAMADA, Takahisa, OHTA, Takeshi

“…Nonalcoholic steatohepatitis (NASH) is a progressive liver disease, and some patients develop hepatic cirrhosis/carcinoma. Animal models play key roles in the…”
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A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet by Suzuki-Kemuriyama, Noriko, Abe, Akari, Uno, Kinuko, Ogawa, Shuji, Watanabe, Atsushi, Sano, Ryuhei, Yuki, Megumi, Miyajima, Katsuhiro, Nakae, Dai

“…Nonalcoholic steatohepatitis (NASH) is a form of liver disease characterized by steatosis, necroinflammation, and fibrosis, resulting in cirrhosis and cancer…”
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Hepatic lesions induced by feeding Western diets to Zucker fatty rats, an insulin-resistant model by Saito, Tomoyuki, Toriniwa, Yasufumi, Ishii, Yukihito, Uemura, Atsuhiro, Miyajima, Katsuhiro, Uno, Kinuko, Shirai, Yuki, Nakae, Dai, Ohta, Takeshi

“…Metabolic diseases including nonalcoholic steatohepatitis develop due to various environmental factors. In particular, the westernization of food is closely…”
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Extracts of black and brown rice powders improve hepatic lipid accumulation via the activation of PPARα in obese and diabetic model mice by Felix, Angelina DR, Takahashi, Nobuyuki, Takahashi, Mami, Katsumata-Tsuboi, Rie, Satoh, Ryo, Soon Hui, Teoh, Miyajima, Katsuhiro, Nakae, Dai, Inoue, Hirofumi, Uehara, Mariko

“…Rice powder extract (RPE) from black and brown rice (Oryza sativa L. indica) improves hepatic lipid accumulation in obese and diabetic model mice via…”
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JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, ameliorates lipid metabolism and attenuates atherosclerosis in hyperlipidemic animal models by Mera, Yasuko, Kawai, Takashi, Ogawa, Naoto, Odani, Naoya, Sasase, Tomohiko, Miyajima, Katsuhiro, Ohta, Takeshi, Kakutani, Makoto

“…JTT-130 was developed as an intestine-specific MTP inhibitor designed to rapidly catabolize after absorption to avoid causing hepatotoxicity due to hepatic MTP…”
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Nonobese mice with nonalcoholic steatohepatitis fed on a choline‐deficient, l‐amino acid‐defined, high‐fat diet exhibit alterations in signaling pathways by Suzuki‐Kemuriyama, Noriko, Abe, Akari, Nakane, Sae, Uno, Kinuko, Ogawa, Shuji, Watanabe, Atsushi, Sano, Ryuhei, Yuki, Megumi, Miyajima, Katsuhiro, Nakae, Dai

“…Nonalcoholic steatohepatitis (NASH) is often associated with obesity, but some patients develop NASH without obesity. The physiological processes by which…”
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