Search Results - "Katsnelson, Lizabeth"

Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF by Ramalingam, Pradeep, Poulos, Michael G., Lazzari, Elisa, Gutkin, Michael C., Lopez, David, Kloss, Christopher C., Crowley, Michael J., Katsnelson, Lizabeth, Freire, Ana G., Greenblatt, Matthew B., Park, Christopher Y., Butler, Jason M.

“…Inflammatory signals arising from the microenvironment have emerged as critical regulators of hematopoietic stem cell (HSC) function during diverse processes…”
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Proteogenomic analysis of cancer aneuploidy and normal tissues reveals divergent modes of gene regulation across cellular pathways by Cheng, Pan, Zhao, Xin, Katsnelson, Lizabeth, Camacho-Hernandez, Elaine M, Mermerian, Angela, Mays, Joseph C, Lippman, Scott M, Rosales-Alvarez, Reyna Edith, Moya, Raquel, Shwetar, Jasmine, Grun, Dominic, Fenyo, David, Davoli, Teresa

“…How cells control gene expression is a fundamental question. The relative contribution of protein-level and RNA-level regulation to this process remains…”
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Proteogenomics unveils mechanistic insights to precision oncology by Dou, Yongchao, Katsnelson, Lizabeth, Zhang, Bing, Fenyö, David, Liu, Tao

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The Impact of Chromosome-Specific Aneuploidies on Immune Evasion in Cancer by Katsnelson, Lizabeth

“…Aneuploidy, an imbalance of chromosome number, is detrimental to normal cell fitness and rarely occurs at the organism level. Paradoxically, about 90% of solid…”
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Integration and Analysis of CPTAC Proteomics Data in the Context of Cancer Genomics in the cBioPortal[S] by Wu, Pamela, Heins, Zachary J., Muller, James T., Katsnelson, Lizabeth, de Bruijn, Ino, Abeshouse, Adam A., Schultz, Nikolaus, Fenyö, David, Gao, Jianjiong

“…Integration of the CPTAC mass spectrometry-based proteomics data into the cBioPortal, consisting of 77 breast, 95 colorectal, and 174 ovarian tumors that…”
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Spatial profiling of mismatch repair deficient endometrial tumors identifies patterns associated with recurrence and response to immune checkpoint therapy by Hermann, Catherine, Hollenberg, Michelle, Katsnelson, Lizabeth, Liu, Wenke, Tan, Jimin, Adler, Esther, Selvaraj, Priya, Loomis, Cynthia, Boyd, Leslie, Fenyo, David

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KaryoCreate: A CRISPR-based technology to study chromosome-specific aneuploidy by targeting human centromeres by Bosco, Nazario, Goldberg, Aleah, Zhao, Xin, Mays, Joseph C., Cheng, Pan, Johnson, Adam F., Bianchi, Joy J., Toscani, Cecilia, Di Tommaso, Elena, Katsnelson, Lizabeth, Annuar, Dania, Mei, Sally, Faitelson, Roni E., Pesselev, Ilan Y., Mohamed, Kareem S., Mermerian, Angela, Camacho-Hernandez, Elaine M., Gionco, Courtney A., Manikas, Julie, Tseng, Yi-Shuan, Sun, Zhengxi, Fani, Somayeh, Keegan, Sarah, Lippman, Scott M., Fenyö, David, Giunta, Simona, Santaguida, Stefano, Davoli, Teresa

“…Aneuploidy, the presence of chromosome gains or losses, is a hallmark of cancer. Here, we describe KaryoCreate (karyotype CRISPR-engineered aneuploidy…”
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Endothelial mTOR maintains hematopoiesis during aging by Ramalingam, Pradeep, Poulos, Michael G, Gutkin, Michael C, Katsnelson, Lizabeth, Freire, Ana G, Lazzari, Elisa, Butler, Jason M

“…Aging leads to a decline in hematopoietic stem and progenitor cell (HSPC) function. We recently discovered that aging of bone marrow endothelial cells (BMECs)…”
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Proteogenomic insights suggest druggable pathways in endometrial carcinoma by Dou, Yongchao, Katsnelson, Lizabeth, Gritsenko, Marina A., Hu, Yingwei, Reva, Boris, Hong, Runyu, Wang, Yi-Ting, Kolodziejczak, Iga, Lu, Rita Jui-Hsien, Tsai, Chia-Feng, Bu, Wen, Liu, Wenke, An, Eunkyung, Chu, Rosalie K., Davoli, Teresa, Demicco, Elizabeth G., Devereaux, Kelly, Dhanasekaran, Saravana M., Dottino, Peter, Hermann, Catherine E., Hiltke, Tara, Hostetter, Galen, Jędryka, Marcin, Jewell, Scott D., Kahn, Andrea G., Ku, Amy T., Kumar-Sinha, Chandan, Lazar, Alexander J., Li, Yi, Lih, Tung-Shing M., McKerrow, Wilson, Mesri, Mehdi, Monroe, Matthew E., Moon, Jamie, Newton, Chelsea, Omelchenko, Tatiana, Payne, Samuel H., Robles, Ana I., Rodriguez, Henry, Ruggles, Kelly V., Rykunov, Dmitry, Shi, Tujin, Shi, Zhiao, Tan, Jimin, Wang, Joshua M., Wen, Bo, Yi, Xinpei, Zhang, Xu, Zhao, Rui, Mutch, David, Nesvizhskii, Alexey I., Mani, D.R., Zhang, Hui, Anderson, Matthew L., Rodland, Karin D., Zhang, Bing, Antczak, Andrzej, Birrer, Michael J., Borucki, Melissa, Calinawan, Anna, Cerda, Sandra, Chesla, David, Cottingham, Sandra, Dhir, Rajiv, Domagalski, Marcin J., Edwards, Nathan J., Ellis, Matthew J., Eschbacher, Jennifer, Fam, Mina, Francis, Jesse, Freymann, John, Gabriel, Stacey, Gillette, Michael A., Godwin, Andrew K., Grady, Pamela, Hafron, Jason, Hindenach, Barbara, Hoadley, Katherine A., Huang, Jasmine, Johnson, Ashlie, Jones, Corbin D., Le, Toan, Ma'ayan, Avi, Madan, Rashna, Mareedu, Sailaja, McGarvey, Peter B., Modugno, Francesmary, Montgomery, Rebecca, Paulovich, Amanda G., Pruetz, Barbara L., Richey, Shannon, Shutack, Yvonne, Singh, Shilpi, Smith, Michael, Tobin, Matt, Um, Ki Sung, Wilson, George D., Zaalishvili, Kakhaber, Zhang, Zhen, Zhao, Grace

“…We characterized a prospective endometrial carcinoma (EC) cohort containing 138 tumors and 20 enriched normal tissues using 10 different omics platforms…”
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Asf1 facilitates dephosphorylation of Rad53 after DNA double-strand break repair by Tsabar, Michael, Waterman, David P, Aguilar, Fiona, Katsnelson, Lizabeth, Eapen, Vinay V, Memisoglu, Gonen, Haber, James E

“…To allow for sufficient time to repair DNA double-stranded breaks (DSBs), eukaryotic cells activate the DNA damage checkpoint. In budding yeast, Rad53…”
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Abstract 955: Proteogenomic insights suggest druggable pathways in endometrial cancer by Katsnelson, Lizabeth, Dou, Yongchao, Gritsenko, Marina A., Anderson, Matthew L., Rodland, Karin D., Zhang, Bing, Liu, Tao, Fenyö, David

“…Abstract Endometrial carcinoma (EC) is the most common gynecologic cancer diagnosed in developed countries, with incidence on the rise globally. Over the past…”
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Complementary and Inducible creER T2 Mouse Models for Functional Evaluation of Endothelial Cell Subtypes in the Bone Marrow by Poulos, Michael G, Ramalingam, Pradeep, Winiarski, Agatha, Gutkin, Michael C, Katsnelson, Lizabeth, Carter, Cody, Pibouin-Fragner, Laurence, Eichmann, Anne, Thomas, Jean-Leon, Miquerol, Lucile, Butler, Jason M

“…In the adult bone marrow (BM), endothelial cells (ECs) are an integral component of the hematopoietic stem cell (HSC)-supportive niche, which modulates HSC…”
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Abstract 445: Integrated proteogenomic characterization across seven histological types of pediatric brain tumors by Petralia, Francesca, Tignor, Nicole, Reva, Boris, Raman, Pichai, Chowdhury, Shrabanti, Rykunov, Dmitry, Krek, Azra, Ma, Weiping, Ji, Jiayi, Song, Xiaoyu, Zhu, Yuankun, Rokita, Jo Lynne, Colaprico, Antonio, Calinawan, Anna, Whiteaker, Jeffrey R., Ivey, Richard G., Gumus, Zeynep, Kalayci, Selim, Garcia, Gonzalo L., Yoo, Seungyeul, Katsnelson, Lizabeth, Wang, Ying, Kennedy, Jacob J., Voytovich, Uliana J., Zhao, Lei, Leprevost, Felipe, Chang, Hui-Yin, Gaonkar, Krutika S., Appert, Elizabeth M., Cuellar, Ximena, Lilly, Jena, Zhu, Jun, Schadt, Eric E., Mesri, Medhi, Boja, Emily, Hiltka, Tara, Rodriguez, Henry, Ding, Li, Iavarone, Antonio, Wiznerowicz, Maciej, Nesvizhskii, Alexey I., Fenyo, David, Gygi, Steven, Paulovich, Amanda, Resnick, Adam C., Storm, Phillip B., Rood, Brian, Wang, Pei

“…Abstract We performed a comprehensive proteogenomic analysis across seven major types of childhood brain tumors for a deeper understanding of their functional…”
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Deep learning integrates histopathology and proteogenomics at a pan-cancer level by Wang, Joshua M, Hong, Runyu, Demicco, Elizabeth G, Tan, Jimin, Lazcano, Rossana, Moreira, Andre L, Li, Yize, Calinawan, Anna, Razavian, Narges, Schraink, Tobias, Gillette, Michael A, Omenn, Gilbert S, An, Eunkyung, Rodriguez, Henry, Tsirigos, Aristotelis, Ruggles, Kelly V, Ding, Li, Robles, Ana I, Mani, D R, Rodland, Karin D, Lazar, Alexander J, Liu, Wenke, Fenyö, David

“…We introduce a pioneering approach that integrates pathology imaging with transcriptomics and proteomics to identify predictive histology features associated…”
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Integration and Analysis of CPTAC Proteomics Data in the Context of Cancer Genomics in the cBioPortal by Wu, Pamela, Heins, Zachary J, Muller, James T, Katsnelson, Lizabeth, de Bruijn, Ino, Abeshouse, Adam A, Schultz, Nikolaus, Fenyö, David, Gao, Jianjiong

“…The Clinical Proteomic Tumor Analysis Consortium (CPTAC) has produced extensive mass spectrometry-based proteomics data for selected breast, colon, and ovarian…”
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