Search Results - "Katsara, Maria"

True colors: A literature review on the spatial distribution of eye and hair pigmentation by Katsara, Maria-Alexandra, Nothnagel, Michael

“…•Compilation of spatial prevalence information on eye and hair pigmentation.•Combination of recent and older sources, together with an uncertainty…”
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Multiple Sclerosis: Immunopathology and Treatment Update by Dargahi, Narges, Katsara, Maria, Tselios, Theodore, Androutsou, Maria-Eleni, de Courten, Maximilian, Matsoukas, John, Apostolopoulos, Vasso

“…The treatment of multiple sclerosis (MS) has changed over the last 20 years. All immunotherapeutic drugs target relapsing remitting MS (RRMS) and it still…”
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Evaluation of supervised machine-learning methods for predicting appearance traits from DNA by Katsara, Maria-Alexandra, Branicki, Wojciech, Walsh, Susan, Kayser, Manfred, Nothnagel, Michael

“…The prediction of human externally visible characteristics (EVCs) based solely on DNA information has become an established approach in forensic and…”
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Imputation-powered whole-exome analysis identifies genes associated with kidney function and disease in the UK Biobank by Wuttke, Matthias, König, Eva, Katsara, Maria-Alexandra, Kirsten, Holger, Farahani, Saeed Khomeijani, Teumer, Alexander, Li, Yong, Lang, Martin, Göcmen, Burulca, Pattaro, Cristian, Günzel, Dorothee, Köttgen, Anna, Fuchsberger, Christian

“…Genome-wide association studies have discovered hundreds of associations between common genotypes and kidney function but cannot comprehensively investigate…”
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Anti-CD20 Agents for Multiple Sclerosis: Spotlight on Ocrelizumab and Ofatumumab by Florou, Despoina, Katsara, Maria, Feehan, Jack, Dardiotis, Efthimios, Apostolopoulos, Vasso

“…Until recently, in the pathogenesis of Multiple Sclerosis (MS), the contribution of B cells has been largely underestimated, and the disease was considered a…”
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Testing the impact of trait prevalence priors in Bayesian-based genetic prediction modeling of human appearance traits by Katsara, Maria-Alexandra, Branicki, Wojciech, Pośpiech, Ewelina, Hysi, Pirro, Walsh, Susan, Kayser, Manfred, Nothnagel, Michael

“…•Predicting appearance phenotypes from genotypes is of forensic and other relevance.•Trait prevalence priors may improve appearance prediction but were not…”
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Harm-to-Benefit Ratio of Fecal Immunochemical Test–Based Screening for Colorectal Cancer Given Prior Fecal Hemoglobin Concentrations by Toes-Zoutendijk, Esther, van de Schootbrugge-Vandermeer, Hilliene J., Katsara, Maria A., de Jonge, Lucie, Spaander, Manon C.W., van Vuuren, Anneke J., van Kemenade, Folkert J., Dekker, Evelien, Nagtegaal, Iris D., van Leerdam, Monique E., Lansdorp-Vogelaar, Iris, Meester, Reinier G.S.

“…This study aimed to provide evidence on the harm-to-benefit ratio of fecal immunochemical test (FIT)–based colorectal cancer (CRC) screening by previous fecal…”
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Round and round we go: cyclic peptides in disease by Katsara, Maria, Tselios, Theodore, Deraos, Spyros, Deraos, George, Matsoukas, Minos-Timotheos, Lazoura, Eliada, Matsoukas, John, Apostolopoulos, Vasso

“…There is a need for novel drugs for the treatment of infectious diseases, autoimmunity and cancer. Cyclic peptides constitute a class of compounds that have…”
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Imputation-Powered Whole-Exome Analysis Identifies Rare Coding Variants and Genes Associated With Kidney Function and Disease in the UK Biobank: FR-PO915 by Katsara, Maria-Alexandra, König, Eva, Wuttke, Matthias

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Cyclization of PLP139-151 peptide reduces its encephalitogenic potential in experimental autoimmune encephalomyelitis by Lourbopoulos, Athanasios, Matsoukas, Minos-Timotheos, Katsara, Maria, Deraos, George, Giannakopoulou, Aggeliki, Lagoudaki, Roza, Grigoriadis, Nikolaos, Matsoukas, John, Apostolopoulos, Vasso

“…[Display omitted] We report the novel synthesis of cyclic PLP139-151 (cPLP) and its application in SJL/J mice to study its encephalitogenic effects. Our…”
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Anti-CD20 Agents for Multiple Sclerosis: Spotlight on Ocrelizumab and Ofatumumab by Florou, Despoina, Katsara, Maria, Feehan, Jack, Dardiotis, Efthimios, Apostolopoulos, Vasso

“…Until recently, in the pathogenesis of Multiple Sclerosis (MS), the contribution of B cells has been largely underestimated, and the disease was considered a…”
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Design of Novel Cyclic Altered Peptide Ligands of Myelin Basic Protein MBP83−99 That Modulate Immune Responses in SJL/J Mice by Katsara, Maria, Deraos, George, Tselios, Theodore, Matsoukas, John, Apostolopoulos, Vasso

“…The use of antagonist peptides derived from the myelin sheath constitutes a promising therapeutic approach for multiple sclerosis (MS). Cyclization of peptide…”
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The good, the bad and the ugly: how altered peptide ligands modulate immunity by Katsara, Maria, Minigo, Gabriela, Plebanski, Magdalena, Apostolopoulos, Vasso

“…The basis of T cell immune responses is the specific recognition of an immunogenic peptide epitope by a T cell receptor. Peptide alterations of such T cell…”
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Design and Synthesis of a Cyclic Double Mutant Peptide (cyclo(87−99)[A91,A96]MBP87−99) Induces Altered Responses in Mice after Conjugation to Mannan: Implications in the Immunotherapy of Multiple Sclerosis by Katsara, Maria, Deraos, George, Tselios, Theodore, Matsoukas, Minos-Timotheos, Friligou, Irene, Matsoukas, John, Apostolopoulos, Vasso

“…Altered peptide ligands that alter immune responses are a promising approach to the immunotherapy of multiple sclerosis. Cyclic peptides are of interest…”
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Citrullination of Linear and Cyclic Altered Peptide Ligands from Myelin Basic Protein (MBP87−99) Epitope Elicits a Th1 Polarized Response by T Cells Isolated from Multiple Sclerosis Patients: Implications in Triggering Disease by Deraos, George, Chatzantoni, Kokona, Matsoukas, Minos-Timotheos, Tselios, Theodore, Deraos, Spyros, Katsara, Maria, Papathanasopoulos, Panagiotis, Vynios, Demitrios, Apostolopoulos, Vasso, Mouzaki, Athanasia, Matsoukas, John

“…Derangement of cellular immunity is central in the pathophysiology of multiple sclerosis (MS) and is often manifested by abnormal cytokine production. We…”
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Altered peptide ligands of myelin basic protein (MBP₈₇₋₉₉) conjugated to reduced mannan modulate immune responses in mice by Katsara, Maria, Yuriev, Elizabeth, Ramsland, Paul A, Tselios, Theodore, Deraos, George, Lourbopoulos, Athanasios, Grigoriadis, Nikolaos, Matsoukas, John, Apostolopoulos, Vasso

“…Mutations of peptides to generate altered peptide ligands, capable of switching immune responses from T helper 1 (Th1) to T helper 2 (Th2), are promising…”
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A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity by Gartlan, Kate H, Belz, Gabrielle T, Tarrant, Jacqueline M, Minigo, Gabriela, Katsara, Maria, Sheng, Kuo-Ching, Sofi, Mariam, van Spriel, Annemiek B, Apostolopoulos, Vasso, Plebanski, Magdalena, Robb, Lorraine, Wright, Mark D

“…The cooperative nature of tetraspanin-tetraspanin interactions in membrane organization suggests functional overlap is likely to be important in tetraspanin…”
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A double mutation of MBP83–99 peptide induces IL-4 responses and antagonizes IFN-γ responses by Katsara, Maria, Yuriev, Elizabeth, Ramsland, Paul A, Deraos, George, Tselios, Theodore, Matsoukas, John, Apostolopoulos, Vasso

“…Abstract A number of treatment options are available to multiple sclerosis patients, however this needs to be improved. Herein, we designed and synthesized a…”
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Immune responses of linear and cyclic PLP139-151 mutant peptides in SJL/J mice: peptides in their free state versus mannan conjugation by Katsara, Maria, Deraos, Spyros, Tselios, Theodore V, Pietersz, Geoffrey, Matsoukas, John, Apostolopoulos, Vasso

“…The predominant proteins of the CNS are myelin basic protein, proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein. PLP139-151 is one of the major…”
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Mannosylation of mutated MBP83-99 peptides diverts immune responses from Th1 to Th2 by Katsara, Maria, Yuriev, Elizabeth, Ramsland, Paul A, Deraos, George, Tselios, Theodore, Matsoukas, John, Apostolopoulos, Vasso

“…Multiple sclerosis (MS) is an autoimmune demyelinating disease mediated primarily by CD4+ T cells. The design of peptide mutants of disease-associated myelin…”
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