Search Results - "Kato, Juran"

An integrative approach using real-world data to identify alternative therapeutic uses of existing drugs by Hosomi, Kouichi, Fujimoto, Mai, Ushio, Kazutaka, Mao, Lili, Kato, Juran, Takada, Mitsutaka

“…Different computational approaches are employed to efficiently identify novel repositioning possibilities utilizing different sources of information and…”
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Inhibitors of Ras/Raf-1 Interaction Identified by Two-Hybrid Screening Revert Ras-Dependent Transformation Phenotypes in Human Cancer Cells by Kato-Stankiewicz, Juran, Hakimi, Irina, Zhi, Gang, Zhang, Jie, Serebriiskii, Ilya, Guo, Lea, Edamatsu, Hironori, Koide, Hiroshi, Menon, Sanjay, Eckl, Robert, Sakamuri, Sukumar, Lu, Yingchun, Chen, Quin-Zene, Agarwal, Seema, Baumbach, William R., Golemis, Erica A., Tamanoi, Fuyuhiko, Khazak, Vladimir

“…The interaction of activated Ras with Raf initiates signaling cascades that contribute to a significant percentage of human tumors, suggesting that agents that…”
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Systematic identification of cellular signals reactivating Kaposi sarcoma-associated herpesvirus by Yu, Fuqu, Harada, Josephine N, Brown, Helen J, Deng, Hongyu, Song, Moon Jung, Wu, Ting-Ting, Kato-Stankiewicz, Juran, Nelson, Christian G, Vieira, Jeffrey, Tamanoi, Fuyuhiko, Chanda, Sumit K, Sun, Ren

“…The herpesvirus life cycle has two distinct phases: latency and lytic replication. The balance between these two phases is critical for viral pathogenesis. It…”
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Activation of the Guanine Nucleotide Exchange Factor Dbl Following ACK1-Dependent Tyrosine Phosphorylation by Kato, Juran, Kaziro, Yoshito, Satoh, Takaya

“…Signals triggered by diverse receptors modulate the activity of Rho family proteins, although the regulatory mechanism remains largely unknown. On the basis of…”
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Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways by Gau, Chia-Ling, Kato-Stankiewicz, Juran, Jiang, Chen, Miyamoto, Susie, Guo, Lea, Tamanoi, Fuyuhiko

“…Farnesyltransferase inhibitors (FTI) have been developed as anticancer drugs and are currently being evaluated in clinical trials. In this study, we have…”
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Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast by Urano, Jun, Comiso, Melissa J., Guo, Lea, Aspuria, Paul‐Joseph, Deniskin, Roman, Tabancay, Angel P., Kato‐Stankiewicz, Juran, Tamanoi, Fuyuhiko

“…Summary Rheb GTPase is a key player in the control of growth, cell cycle and nutrient uptake that is conserved from yeast to humans. To further our…”
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Stimulation of Ras Guanine Nucleotide Exchange Activity of Ras-GRF1/CDC25Mm upon Tyrosine Phosphorylation by the Cdc42-regulated Kinase ACK1 by Kiyono, Mari, Kato, Juran, Kataoka, Tohru, Kaziro, Yoshito, Satoh, Takaya

“…Ras-GRF1 is a brain-specific guanine nucleotide exchange factor (GEF) for Ras, whose activity is regulated in response to Ca2+ influx and G protein-coupled…”
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Epidermal Growth Factor Stimulation of the ACK1/Dbl Pathway in a Cdc42 and Grb2-Dependent Manner by Kato-Stankiewicz, Juran, Ueda, Shuji, Kataoka, Tohru, Kaziro, Yoshito, Satoh, Takaya

“…The tyrosine kinase ACK1 phosphorylates and activates the guanine nucleotide exchange factor Dbl, which in turn directs the Rho family GTP-binding proteins…”
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Design and Synthesis of Novel DFG-Out RAF/Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Inhibitors. 1. Exploration of [5,6]-Fused Bicyclic Scaffolds by Okaniwa, Masanori, Hirose, Masaaki, Imada, Takashi, Ohashi, Tomohiro, Hayashi, Youko, Miyazaki, Tohru, Arita, Takeo, Yabuki, Masato, Kakoi, Kazuyo, Kato, Juran, Takagi, Terufumi, Kawamoto, Tomohiro, Yao, Shuhei, Sumita, Akihiko, Tsutsumi, Shunichirou, Tottori, Tsuneaki, Oki, Hideyuki, Sang, Bi-Ching, Yano, Jason, Aertgeerts, Kathleen, Yoshida, Sei, Ishikawa, Tomoyasu

“…To develop RAF/VEGFR2 inhibitors that bind to the inactive DFG-out conformation, we conducted structure-based drug design using the X-ray cocrystal structures…”
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Farnesylated proteins and cell cycle progression by Tamanoi, Fuyuhiko, Kato-Stankiewicz, Juran, Jiang, Chen, Machado, Iara, Thapar, Nitika

“…Post‐translational modification of proteins by the addition of a farnesyl group is critical for the function of a number of proteins involved in signal…”
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Yeast screens for inhibitors of Ras-Raf interaction and characterization of MCP inhibitors of Ras-Raf interaction by Khazak, Vladimir, Kato-Stankiewicz, Juran, Tamanoi, Fuyu, Golemis, Erica A

“…Because of the central role of Ras in cancer cell signaling, there has been considerable interest in developing small molecule inhibitors of the Ras signaling…”
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A Two-Hybrid Approach to Identify Inhibitors of the RAS–RAF Interaction by Khazak, Vladimir, Eyrisch, Susanne, Kato, Juran, Tamanoi, Fuyuhiko, Golemis, Erica A.

“…MCP compounds were developed with the idea to inhibit RAS/RAF interaction. They were identified by carrying out high-throughput screens of chemical compounds…”
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Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1 by Kiyono, M, Kato, J, Kataoka, T, Kaziro, Y, Satoh, T

“…Ras-GRF1 is a brain-specific guanine nucleotide exchange factor (GEF) for Ras, whose activity is regulated in response to Ca(2+) influx and G protein-coupled…”
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Tyrosine phosphorylation of ACK in response to temperature shift-down, hyperosmotic shock, and epidermal growth factor stimulation by Satoh, Takaya, Kato, Juran, Nishida, Kazuhiko, Kaziro, Yoshito

“…The mammalian Cdc42 protein regulates various kinds of cellular responses, including formation of filopodia, polarization of T cells, and cell cycle…”
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Systematic identification of cellular signals reactivating Kaposi sarcoma--associated herpesvirus by Yu, Fuqu, Harada, Josephine N, Brown, Helen J, Deng, Hongyu, Song, Moon Jung, Wu, Ting-Ting, Kato-Stankiewicz, Juran, Nelson, Christian G, Vieira, Jeffrey, Tamanoi, Fuyuhiko, Chanda, Sumit K, Sun, Ren

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